Zobrazeno 1 - 10
of 180
pro vyhledávání: '"Massimo Tabaton"'
Autor:
Matilde Bongianni, Anna Ladogana, Stefano Capaldi, Sigrid Klotz, Simone Baiardi, Annachiara Cagnin, Daniela Perra, Michele Fiorini, Anna Poleggi, Giuseppe Legname, Tatiana Cattaruzza, Francesco Janes, Massimo Tabaton, Bernardino Ghetti, Salvatore Monaco, Gabor G. Kovacs, Piero Parchi, Maurizio Pocchiari, Gianluigi Zanusso
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 6, Iss 10, Pp 2120-2126 (2019)
Abstract We applied RT‐QuIC assay to detect α‐synuclein aggregates in cerebrospinal fluid (CSF) of patients with suspected Creutzfeldt–Jakob disease who had a neuropathological diagnosis of dementia with Lewy bodies (DLB) (n = 7), other neurod
Externí odkaz:
https://doaj.org/article/f4deb6fe7ffd42969999bc511093e3f8
Autor:
Gabriella Testa, Erica Staurenghi, Serena Giannelli, Simona Gargiulo, Michela Guglielmotto, Massimo Tabaton, Elena Tamagno, Paola Gamba, Gabriella Leonarduzzi
Publikováno v:
Redox Biology, Vol 17, Iss , Pp 423-431 (2018)
It is now established that cholesterol oxidation products (oxysterols) are involved in several events underlying Alzheimer's disease (AD) pathogenesis. Of note, certain oxysterols cause neuron dysfunction and degeneration but, recently, some of them
Externí odkaz:
https://doaj.org/article/22c9b1cba0444471aaea76f33f06d0b8
Oxidative Stress and Beta Amyloid in Alzheimer’s Disease. Which Comes First: The Chicken or the Egg?
Publikováno v:
Antioxidants, Vol 10, Iss 9, p 1479 (2021)
The pathogenesis of Alzheimer’s disease involves β amyloid (Aβ) accumulation known to induce synaptic dysfunction and neurodegeneration. The brain’s vulnerability to oxidative stress (OS) is considered a crucial detrimental factor in Alzheimer
Externí odkaz:
https://doaj.org/article/98bd5bc4c1af478296cde1e4ee9c1c4b
Autor:
Michela Guglielmotto, Debora Monteleone, Valeria Vasciaveo, Ivan Enrico Repetto, Giusi Manassero, Massimo Tabaton, Elena Tamagno
Publikováno v:
Frontiers in Aging Neuroscience, Vol 9 (2017)
Alzheimer’s disease (AD) is a multifactorial pathology causing common brain spectrum disorders in affected patients. These mixed neurological disorders not only include structural AD brain changes but also cerebrovascular lesions. The main aim of t
Externí odkaz:
https://doaj.org/article/d479db49f31f46758dbfd372e765f4f3
Autor:
Sara Massone, Irene Vassallo, Gloria Fiorino, Manuele Castelnuovo, Federica Barbieri, Roberta Borghi, Massimo Tabaton, Mauro Robello, Elena Gatta, Claudio Russo, Tullio Florio, Giorgio Dieci, Ranieri Cancedda, Aldo Pagano
Publikováno v:
Neurobiology of Disease, Vol 41, Iss 2, Pp 308-317 (2011)
Alternative splicing is a central component of human brain complexity; nonetheless, its regulatory mechanisms are still largely unclear. In this work, we describe a novel non-coding (nc) RNA (named 17A) RNA polymerase (pol) III-dependent embedded in
Externí odkaz:
https://doaj.org/article/86e6db654bc14977b656f5a4e3fe1545
Autor:
Alessandra Piccini, Anna Fassio, Elena Pasqualetto, Antonella Vitali, Roberta Borghi, Daniela Palmieri, Benedetta Nacmias, Sandro Sorbi, Roberto Sitia, Massimo Tabaton
Publikováno v:
Neurobiology of Disease, Vol 15, Iss 2, Pp 380-386 (2004)
Many patients affected by early onset familial Alzheimer's disease (FAD), carry mutations in the presenilin 1 (PS1) gene. Since it has been suggested that FAD-linked PS1 mutations impair the unfolded protein response (UPR) due to endoplasmic reticulu
Externí odkaz:
https://doaj.org/article/b2ca97ac89ff4dbfa38e0aa04dc487c0
Autor:
Elena Tamagno, Paola Bardini, Alessandra Obbili, Antonella Vitali, Roberta Borghi, Damiano Zaccheo, Maria A. Pronzato, Oliviero Danni, Mark A. Smith, George Perry, Massimo Tabaton
Publikováno v:
Neurobiology of Disease, Vol 10, Iss 3, Pp 279-288 (2002)
Recently an aspartyl protease with β-secretase activity called BACE was identified. In the present paper we showed that BACE is modulated by the oxidative stress product 4-hydroxynonenal (HNE). Exposure of NT2 neurons to the two classical pro-oxidan
Externí odkaz:
https://doaj.org/article/9f2bf446cb9a48cfb665296275e4ef51
Publikováno v:
Frontiers in Aging Neuroscience, Vol 2 (2010)
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder affecting the elderly population. Mechanistically, the major cause of the disease bases on the altered processing of the amyloid-β (Aβ) precursor protein (APP), resulting in the
Externí odkaz:
https://doaj.org/article/853cacb6f6a54cf68aa4969d5e3932a6
Oxidative Stress and Beta Amyloid in Alzheimer’s Disease. Which Comes First: The Chicken or the Egg?
Publikováno v:
Antioxidants, Vol 10, Iss 1479, p 1479 (2021)
Antioxidants
Antioxidants
The pathogenesis of Alzheimer’s disease involves β amyloid (Aβ) accumulation known to induce synaptic dysfunction and neurodegeneration. The brain’s vulnerability to oxidative stress (OS) is considered a crucial detrimental factor in Alzheimer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa92f775765c5232cae322a158420255
https://www.mdpi.com/2076-3921/10/9/1479
https://www.mdpi.com/2076-3921/10/9/1479
Autor:
Michela Guglielmotto, Valeria Vasciaveo, Debora Monteleone, Claudio Franchino, Massimo Tabaton, Elena Tamagno, Sara Rinaldi, Ivan Enrico Repetto
Publikováno v:
Journal of Alzheimer's disease : JAD. 71(3)
Neuroinflammation is involved in the pathogenesis of Alzheimer's disease, and the transcription factor NF-kappa B is a player in this event. We found here that the ischemic damage alone or in association with A beta(1-42) activates the NF-kappa B pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f0b60571bf01d4bd7cf855767f8228
https://pubmed.ncbi.nlm.nih.gov/31450501
https://pubmed.ncbi.nlm.nih.gov/31450501