P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development

Autor: Sarah Bowling, Aida Di Gregorio, Margarida Sancho, Sara Pozzi, Marieke Aarts, Massimo Signore, Michael D. Schneider, Juan Pedro Martinez-Barbera, Jesús Gil, Tristan A. Rodríguez

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

During embryo development, cell fitness determines survival but how this is regulated is unclear. Here, the authors show that in early embryonic development and stem cells exiting the naive state, cells sense the fitness of their neighbours and trigg

Externí odkaz: https://doaj.org/article/fa84dfb29e394c458e23e23541902818

P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development

Autor: Marieke Aarts, Jesús Gil, Sarah Bowling, Sara Pozzi, Massimo Signore, Juan Pedro Martinez-Barbera, Tristan A. Rodriguez, Michael D. Schneider, Margarida Sancho, Aida Di Gregorio

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

Ensuring the fitness of the pluripotent cells that will contribute to future development is important both for the integrity of the germline and for proper embryogenesis. Consequently, it is becoming increasingly apparent that pluripotent cells can c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e072aba2748032a620f1ea7db31137a0
https://doi.org/10.1038/s41467-018-04167-y

Transcription factor 7-like 1 is involved in hypothalamo-pituitary axis development in mice and humans

Autor: Rodrigo M. Young, Mark J. McCabe, Sara Pozzi, Bradley J. Merrill, James P. G. Turton, Valeria Scagliotti, Basudha Basu, Gabriela Carreno, Carles Gaston-Massuet, Markela Koniordou, Chun I. Wu, Federica Graziola, Elisa Rahikkala, Tuija Löppönen, Mehul T. Dattani, Massimo Signore, Sujatha A. Jayakody, Seyedeh Neda Mousavy Gharavy, Louise C. Gregory, Angelica Gualtieri, Sergei Y. Sokol, Riitta Veijola, Rodrigo E Bancalari, Juan Pedro Martinez-Barbera, Stephen W. Wilson, Cynthia L. Andoniadou, Nicoletta Charolidi

Publikováno v: Gaston-Massuet, C, McCabe, M J, Scagliotti, V, Young, R M, Carreno, G, Gregory, L C, Jayakody, S A, Pozzi, S, Gualtieri, A, Basu, B, Koniordou, M, Wu, C-I, Bancalari, R E, Rahikkala, E, Veijola, R, Lopponen, T, Graziola, F, Turton, J, Signore, M, Mousavy Gharavy, S N, Charolidi, N, Sokol, S Y, Andoniadou, C L, Wilson, S W, Merrill, B J, Dattani, M T & Martinez-Barbera, J P 2016, ' Transcription factor 7-like 1 is involved in hypothalamo-pituitary axis development in mice and humans ', Proceedings of the National Academy of Sciences of the United States of America . https://doi.org/10.1073/pnas.1503346113

Aberrant embryonic development of the hypothalamus and/or pituitary gland in humans results in congenital hypopituitarism (CH). Transcription factor 7-like 1 (TCF7L1), an important regulator of the WNT/β-catenin signaling pathway, is expressed in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::489990bf9fe05fbe0256ad9326da327c
https://kclpure.kcl.ac.uk/en/publications/7ce20e71-c58a-4587-a3ad-c31ad2845f63

DNMT1 interacts with the developmental transcriptional repressor HESX1

Autor: Paul J. Hurd, Juan Pedro Martinez-Barbera, Massimo Signore, Carles Gaston-Massuet, Ezat Sajedi, Cynthia L. Andoniadou, Mehul T. Dattani

Publikováno v: Biochimica et Biophysica Acta

Hesx1 is a highly conserved homeobox gene present in vertebrates, but absent from invertebrates. Gene targeting experiments in mice have shown that this transcriptional repressor is required for normal forebrain and pituitary development. In humans,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::754d3009870d4d3e4a3c0087778e8714
http://europepmc.org/articles/PMC2233781

Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development

Autor: Kimberly D. Tremblay, Roque Bort, Juan Pedro Martinez Barbera, Massimo Signore, Kenneth S. Zaret

Publikováno v: Developmental Biology. 290(1):44-56

Little is known about the mechanism by which embryonic liver, lung, and pancreas progenitor cells emerge from the endodermal epithelium to initiate organogenesis. Understanding this process and its genetic control provides insight into ontogeny, deve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45d20c4d0b995953f7d4bada94627e98