Zobrazeno 1 - 10
of 254
pro vyhledávání: '"Massimo M. Santoro"'
Autor:
Liaisan Arslanbaeva, Giovanni Tosi, Marco Ravazzolo, Manuela Simonato, Francesco A. Tucci, Salvatore Pece, Paola Cogo, Massimo M. Santoro
Publikováno v:
Redox Biology, Vol 51, Iss , Pp 102272- (2022)
Cutaneous melanoma is the deadliest type of skin cancer, although it accounts for a minority of all skin cancers. Oxidative stress is involved in all stages of melanomagenesis and cutaneous melanoma can sustain a much higher load of Reactive Oxygen S
Externí odkaz:
https://doaj.org/article/8321c1fe9acb4cf3a445f5d98c392ee1
Publikováno v:
Cancers, Vol 14, Iss 11, p 2735 (2022)
Cancer is a leading cause of death worldwide. If left untreated, tumors tend to grow and spread uncontrolled until the patient dies. To support this growth, cancer cells need large amounts of nutrients and growth factors that are supplied and distrib
Externí odkaz:
https://doaj.org/article/7436aae7ca374ad5ac418275e4717ab7
Autor:
Oliver A. Stone, Mohamed El-Brolosy, Kerstin Wilhelm, Xiaojing Liu, Ana M. Romão, Elisabetta Grillo, Jason K. H. Lai, Stefan Günther, Sylvia Jeratsch, Carsten Kuenne, I-Ching Lee, Thomas Braun, Massimo M. Santoro, Jason W. Locasale, Michael Potente, Didier Y. R. Stainier
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
The glycolytic enzyme pyruvate kinase M2 (PKM2) is required for nucleotide synthesis and cell proliferation. Using gene expression and metabolomics analyses, the authors here show that PKM2 regulates methionine metabolism and DNA methylation in endot
Externí odkaz:
https://doaj.org/article/193983107e6a406b9727e989c6776bf0
Publikováno v:
Redox Biology, Vol 37, Iss , Pp 101753- (2020)
Cutaneous melanoma is the most aggressive type of skin cancer. Although cutaneous melanoma accounts for a minority of all types of skin cancer, it causes the greatest number of skin cancer related deaths worldwide. Oxidative stress and redox homeosta
Externí odkaz:
https://doaj.org/article/cef5ba2365204adba1e092257d712435
Autor:
Emiliano Panieri, Massimo M. Santoro
Publikováno v:
Data in Brief, Vol 12, Iss C, Pp 427-432 (2017)
In this article we used transgenic zebrafish lines that express compartment-specific isoforms of the roGFP2-Orp1 and Grx1-roGFP2 biosensors, described in Panieri et al (2017) [1], to test the contribute of the pentose phosphate pathway and of the glu
Externí odkaz:
https://doaj.org/article/91521f762bce4bfb83ff1f88b65a5638
Publikováno v:
Cell Reports, Vol 18, Iss 4, Pp 1033-1047 (2017)
Vascular mural cells (vMCs) are essential components of the vertebrate vascular system, controlling blood vessel maturation and homeostasis. Discrete molecular mechanisms have been associated with vMC development and differentiation. The function of
Externí odkaz:
https://doaj.org/article/2e5ccb3f9c8646dca3deaa0e3564ef38
Autor:
Saravana K. Ramasamy, Anjali P. Kusumbe, Maria Schiller, Dagmar Zeuschner, M. Gabriele Bixel, Carlo Milia, Jaba Gamrekelashvili, Anne Limbourg, Alexander Medvinsky, Massimo M. Santoro, Florian P. Limbourg, Ralf H. Adams
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Formation of new blood vessels and bone is coupled. Here the authors show that blood flow represents a key regulator of angiogenesis and endothelial Notch signalling in the bone, and that reactivation of Notch signalling in the endothelium of aged mi
Externí odkaz:
https://doaj.org/article/60215c37da3249169fe55bc0ec7526b8
Autor:
Giulia Mana, Fabiana Clapero, Emiliano Panieri, Valentina Panero, Ralph T. Böttcher, Hui-Yuan Tseng, Federico Saltarin, Elena Astanina, Katarzyna I. Wolanska, Mark R. Morgan, Martin J. Humphries, Massimo M. Santoro, Guido Serini, Donatella Valdembri
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-20 (2016)
During vascular development, fibronectin (FN) is polymerized at the basolateral side of endothelial cells. Here Mana et al. propose a model where PPFIA1 drives recycling of the FN receptor, a5β1 integrin, to the cell surface and enables polar secret
Externí odkaz:
https://doaj.org/article/90e8d111851f4825bda14ec5af3b9486
Autor:
Massimo M. Santoro, Monica Beltrame, Daniela Panáková, Arndt F. Siekmann, Natascia Tiso, Marina Venero Galanternik, Hyun Min Jung, Brant M. Weinstein
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Since its introduction, the zebrafish has provided an important reference system to model and study cardiovascular development as well as lymphangiogenesis in vertebrates. A scientific workshop, held at the 2018 European Zebrafish Principal Investiga
Externí odkaz:
https://doaj.org/article/c5bd31a428304e608309d2e7b68f3346
Autor:
Vitor Fortuna, Luc Pardanaud, Isabelle Brunet, Roxana Ola, Emma Ristori, Massimo M. Santoro, Stefania Nicoli, Anne Eichmann
Publikováno v:
Cell Reports, Vol 11, Iss 11, Pp 1786-1796 (2015)
The sympathetic nervous system controls smooth muscle tone and heart rate in the cardiovascular system. Postganglionic sympathetic neurons (SNs) develop in close proximity to the dorsal aorta (DA) and innervate visceral smooth muscle targets. Here, w
Externí odkaz:
https://doaj.org/article/e766c9dd225247fc86f7a7bf2e5525bf