Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Massimo M. Santoro"'
Cancer cell stiffening via CoQ10 and UBIAD1 regulates ECM signaling and ferroptosis in breast cancer
Autor:
Giovanni Tosi, Alessandro Paoli, Gaia Zuccolotto, Emilia Turco, Manuela Simonato, Daniela Tosoni, Francesco Tucci, Pietro Lugato, Monica Giomo, Nicola Elvassore, Antonio Rosato, Paola Cogo, Salvatore Pece, Massimo M. Santoro
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract CoQ10 (Coenzyme Q10) is an essential fat-soluble metabolite that plays a key role in cellular metabolism. A less-known function of CoQ10 is whether it may act as a plasma membrane-stabilizing agent and whether this property can affect cancer
Externí odkaz:
https://doaj.org/article/fcdadd32e3c74c049a3cabd84a68dbf7
Autor:
Liaisan Arslanbaeva, Giovanni Tosi, Marco Ravazzolo, Manuela Simonato, Francesco A. Tucci, Salvatore Pece, Paola Cogo, Massimo M. Santoro
Publikováno v:
Redox Biology, Vol 51, Iss , Pp 102272- (2022)
Cutaneous melanoma is the deadliest type of skin cancer, although it accounts for a minority of all skin cancers. Oxidative stress is involved in all stages of melanomagenesis and cutaneous melanoma can sustain a much higher load of Reactive Oxygen S
Externí odkaz:
https://doaj.org/article/8321c1fe9acb4cf3a445f5d98c392ee1
Publikováno v:
Redox Biology, Vol 37, Iss , Pp 101753- (2020)
Cutaneous melanoma is the most aggressive type of skin cancer. Although cutaneous melanoma accounts for a minority of all types of skin cancer, it causes the greatest number of skin cancer related deaths worldwide. Oxidative stress and redox homeosta
Externí odkaz:
https://doaj.org/article/cef5ba2365204adba1e092257d712435
Autor:
Oliver A. Stone, Mohamed El-Brolosy, Kerstin Wilhelm, Xiaojing Liu, Ana M. Romão, Elisabetta Grillo, Jason K. H. Lai, Stefan Günther, Sylvia Jeratsch, Carsten Kuenne, I-Ching Lee, Thomas Braun, Massimo M. Santoro, Jason W. Locasale, Michael Potente, Didier Y. R. Stainier
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
The glycolytic enzyme pyruvate kinase M2 (PKM2) is required for nucleotide synthesis and cell proliferation. Using gene expression and metabolomics analyses, the authors here show that PKM2 regulates methionine metabolism and DNA methylation in endot
Externí odkaz:
https://doaj.org/article/193983107e6a406b9727e989c6776bf0
Autor:
Emiliano Panieri, Massimo M. Santoro
Publikováno v:
Data in Brief, Vol 12, Iss C, Pp 427-432 (2017)
In this article we used transgenic zebrafish lines that express compartment-specific isoforms of the roGFP2-Orp1 and Grx1-roGFP2 biosensors, described in Panieri et al (2017) [1], to test the contribute of the pentose phosphate pathway and of the glu
Externí odkaz:
https://doaj.org/article/91521f762bce4bfb83ff1f88b65a5638
Publikováno v:
Cell Reports, Vol 18, Iss 4, Pp 1033-1047 (2017)
Vascular mural cells (vMCs) are essential components of the vertebrate vascular system, controlling blood vessel maturation and homeostasis. Discrete molecular mechanisms have been associated with vMC development and differentiation. The function of
Externí odkaz:
https://doaj.org/article/2e5ccb3f9c8646dca3deaa0e3564ef38
Autor:
Saravana K. Ramasamy, Anjali P. Kusumbe, Maria Schiller, Dagmar Zeuschner, M. Gabriele Bixel, Carlo Milia, Jaba Gamrekelashvili, Anne Limbourg, Alexander Medvinsky, Massimo M. Santoro, Florian P. Limbourg, Ralf H. Adams
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Formation of new blood vessels and bone is coupled. Here the authors show that blood flow represents a key regulator of angiogenesis and endothelial Notch signalling in the bone, and that reactivation of Notch signalling in the endothelium of aged mi
Externí odkaz:
https://doaj.org/article/60215c37da3249169fe55bc0ec7526b8
Autor:
Giulia Mana, Fabiana Clapero, Emiliano Panieri, Valentina Panero, Ralph T. Böttcher, Hui-Yuan Tseng, Federico Saltarin, Elena Astanina, Katarzyna I. Wolanska, Mark R. Morgan, Martin J. Humphries, Massimo M. Santoro, Guido Serini, Donatella Valdembri
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-20 (2016)
During vascular development, fibronectin (FN) is polymerized at the basolateral side of endothelial cells. Here Mana et al. propose a model where PPFIA1 drives recycling of the FN receptor, a5β1 integrin, to the cell surface and enables polar secret
Externí odkaz:
https://doaj.org/article/90e8d111851f4825bda14ec5af3b9486
Autor:
Massimo M. Santoro, Monica Beltrame, Daniela Panáková, Arndt F. Siekmann, Natascia Tiso, Marina Venero Galanternik, Hyun Min Jung, Brant M. Weinstein
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Since its introduction, the zebrafish has provided an important reference system to model and study cardiovascular development as well as lymphangiogenesis in vertebrates. A scientific workshop, held at the 2018 European Zebrafish Principal Investiga
Externí odkaz:
https://doaj.org/article/c5bd31a428304e608309d2e7b68f3346
Publikováno v:
Cardiovascular Research.
Aims The circadian clock is an internal biological timer that co-ordinates physiology and gene expression with the 24-h solar day. Circadian clock perturbations have been associated to vascular dysfunctions in mammals, and a function of the circadian