Zobrazeno 1 - 10
of 255
pro vyhledávání: '"Massimo M Santoro"'
Cancer cell stiffening via CoQ10 and UBIAD1 regulates ECM signaling and ferroptosis in breast cancer
Autor:
Giovanni Tosi, Alessandro Paoli, Gaia Zuccolotto, Emilia Turco, Manuela Simonato, Daniela Tosoni, Francesco Tucci, Pietro Lugato, Monica Giomo, Nicola Elvassore, Antonio Rosato, Paola Cogo, Salvatore Pece, Massimo M. Santoro
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract CoQ10 (Coenzyme Q10) is an essential fat-soluble metabolite that plays a key role in cellular metabolism. A less-known function of CoQ10 is whether it may act as a plasma membrane-stabilizing agent and whether this property can affect cancer
Externí odkaz:
https://doaj.org/article/fcdadd32e3c74c049a3cabd84a68dbf7
Autor:
Jacoba J Louw, Ricardo Nunes Bastos, Xiaowen Chen, Céline Verdood, Anniek Corveleyn, Yaojuan Jia, Jeroen Breckpot, Marc Gewillig, Hilde Peeters, Massimo M Santoro, Francis Barr, Koenraad Devriendt
Publikováno v:
PLoS Genetics, Vol 14, Iss 1, p e1007138 (2018)
Congenital or neonatal cardiomyopathies are commonly associated with a poor prognosis and have multiple etiologies. In two siblings, a male and female, we identified an undescribed type of lethal congenital restrictive cardiomyopathy affecting the ri
Externí odkaz:
https://doaj.org/article/cf21c2e3cdb24d1aaa1396695663f34b
Autor:
Thomas R Whitesell, Regan M Kennedy, Alyson D Carter, Evvi-Lynn Rollins, Sonja Georgijevic, Massimo M Santoro, Sarah J Childs
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90590 (2014)
Mural cells of the vascular system include vascular smooth muscle cells (SMCs) and pericytes whose role is to stabilize and/or provide contractility to blood vessels. One of the earliest markers of mural cell development in vertebrates is α smooth m
Externí odkaz:
https://doaj.org/article/2c96c038c6424675aa829c7cc48f0b75
Publikováno v:
Redox Biology, Vol 37, Iss , Pp 101753- (2020)
Cutaneous melanoma is the most aggressive type of skin cancer. Although cutaneous melanoma accounts for a minority of all types of skin cancer, it causes the greatest number of skin cancer related deaths worldwide. Oxidative stress and redox homeosta
Externí odkaz:
https://doaj.org/article/cef5ba2365204adba1e092257d712435
Publikováno v:
Cardiovascular Research.
Aims The circadian clock is an internal biological timer that co-ordinates physiology and gene expression with the 24-h solar day. Circadian clock perturbations have been associated to vascular dysfunctions in mammals, and a function of the circadian
Autor:
Nicola Facchinello, Matteo Astone, Matteo Audano, Roxana E. Oberkersch, Marianna Spizzotin, Enrica Calura, Madalena Marques, Mihaela Crisan, Nico Mitro, Massimo M. Santoro
Publikováno v:
Nature Metabolism
Facchinello, N, Astone, M, Audano, M, Oberkersch, R E, Spizzotin, M, Calura, E, Marques, M, Crisan, M, Mitro, N & Santoro, M M 2022, ' Oxidative pentose phosphate pathway controls vascular mural cell coverage by regulating extracellular matrix composition ', Nature Metabolism, vol. 4, no. 1, pp. 123-140 . https://doi.org/10.1038/s42255-021-00514-4
Facchinello, N, Astone, M, Audano, M, Oberkersch, R E, Spizzotin, M, Calura, E, Marques, M, Crisan, M, Mitro, N & Santoro, M M 2022, ' Oxidative pentose phosphate pathway controls vascular mural cell coverage by regulating extracellular matrix composition ', Nature Metabolism, vol. 4, no. 1, pp. 123-140 . https://doi.org/10.1038/s42255-021-00514-4
Vascular mural cells (vMCs) play an essential role in the development and maturation of the vasculature by promoting vessel stabilization through their interactions with endothelial cells. Whether endothelial metabolism influences mural cell recruitm
Publikováno v:
Methods in Molecular Biology ISBN: 9781071627020
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::875a6490c004b5cb05b13de83e21c277
https://doi.org/10.1007/978-1-0716-2703-7_15
https://doi.org/10.1007/978-1-0716-2703-7_15
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2572
The use of transgenic animals carrying exogenous DNA integrated in their genome is a routine in modern-day laboratories. Nowadays, the zebrafish system represents the most useful tool for transgenesis studies mainly due to easy accessibility and mani
Publikováno v:
Nature metabolism. 4(6)
Autor:
Roxana E. Oberkersch, Giovanna Pontarin, Matteo Astone, Marianna Spizzotin, Liaisan Arslanbaeva, Giovanni Tosi, Emiliano Panieri, Sara Ricciardi, Maria Francesca Allega, Alessia Brossa, Paolo Grumati, Benedetta Bussolati, Stefano Biffo, Saverio Tardito, Massimo M. Santoro
Angiogenesis, the active formation of new blood vessels from pre-existing ones, is a complex and demanding biological process that plays an important role in physiological as well as pathological settings. Recent evidence supports cell metabolism as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef01762b0a666724967e4c91e48d5931
https://hdl.handle.net/11588/899906
https://hdl.handle.net/11588/899906