Zobrazeno 1 - 10
of 270
pro vyhledávání: '"Massimo Locati"'
Autor:
Chiara Sfogliarini, Giovanna Pepe, Candida Maria Cesta, Marcello Allegretti, Massimo Locati, Elisabetta Vegeto
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 165, Iss , Pp 115008- (2023)
Raloxifene belongs to the family of Selective Estrogen Receptor Modulators (SERMs), which are drugs widely prescribed for Estrogen Receptor alpha (ERα)-related pathologies. Recently, SERMs are being tested in repurposing strategies for ERα-independ
Externí odkaz:
https://doaj.org/article/9a6a87e50c294c0f97dd5ee7f83ec49d
Autor:
Elisa Setten, Alessandra Castagna, Josué Manik Nava-Sedeño, Jonathan Weber, Roberta Carriero, Andreas Reppas, Valery Volk, Jessica Schmitz, Wilfried Gwinner, Haralampos Hatzikirou, Friedrich Feuerhake, Massimo Locati
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Renal fibrosis is a progressive process with complex etiopathology, causing organ failure. Here authors present a mathematical model, based on an in vitro system faithfully contemplating macrophage-fibroblast interaction and the metabolic-immunologic
Externí odkaz:
https://doaj.org/article/9bf0aac27ae14ea890d07134746ab045
Autor:
Rajesh Kumar, Samantha Milanesi, Martyna Szpakowska, Laura Dotta, Dario Di Silvestre, Anna Maria Trotta, Anna Maria Bello, Mauro Giacomelli, Manuela Benedito, Joana Azevedo, Alexandra Pereira, Emilia Cortesao, Alessandro Vacchini, Alessandra Castagna, Marinella Pinelli, Daniele Moratto, Raffaella Bonecchi, Massimo Locati, Stefania Scala, Andy Chevigné, Elena M. Borroni, Raffaele Badolato
Publikováno v:
JCI Insight, Vol 8, Iss 5 (2023)
WHIM syndrome is an inherited immune disorder caused by an autosomal dominant heterozygous mutation in CXCR4. The disease is characterized by neutropenia/leukopenia (secondary to retention of mature neutrophils in bone marrow), recurrent bacterial in
Externí odkaz:
https://doaj.org/article/7e8f0556adc1400ca6095111ef354886
Autor:
Claudia Carenza, Sara Franzese, Alessandra Castagna, Sara Terzoli, Matteo Simonelli, Pasquale Persico, Lorenzo Bello, Marco Conti Nibali, Federico Pessina, Paolo Kunderfranco, Clelia Peano, Simone Balin, Joanna Mikulak, Francesca Calcaterra, Raffaella Bonecchi, Benedetta Savino, Massimo Locati, Silvia Della Bella, Domenico Mavilio
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
IntroductionAdult-type diffuse gliomas are malignant primary brain tumors characterized by very poor prognosis. Dendritic cells (DCs) are key in priming antitumor effector functions in cancer, but their role in gliomas remains poorly understood.Metho
Externí odkaz:
https://doaj.org/article/c5fce43a13f743ad9cbbc87709c2dfa9
Autor:
Alessandro Vacchini, Elisa Maffioli, Dario Di Silvestre, Cinzia Cancellieri, Samantha Milanesi, Simona Nonnis, Sabrina Badanai, Pierluigi Mauri, Armando Negri, Massimo Locati, Gabriella Tedeschi, Elena Monica Borroni
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
ACKR2 is an atypical chemokine receptor which is structurally uncoupled from G proteins and is unable to activate signaling pathways used by conventional chemokine receptors to promote cell migration. Nonetheless, ACKR2 regulates inflammatory and imm
Externí odkaz:
https://doaj.org/article/bde15963e014423c9585dbe4db42066b
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
In this article, we review the role of mathematical modelling to elucidate the impact of tumor-associated macrophages (TAMs) in tumor progression and therapy design. We first outline the biology of TAMs, and its current application in tumor therapies
Externí odkaz:
https://doaj.org/article/396f8f3283f04682810cb593f34ea8bb
Autor:
Alessandra Rigamonti, Alessandra Castagna, Marika Viatore, Federico Simone Colombo, Sara Terzoli, Clelia Peano, Federica Marchesi, Massimo Locati
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Monocytes are critical cells of the immune system but their role as effectors is relatively poorly understood, as they have long been considered only as precursors of tissue macrophages or dendritic cells. Moreover, it is known that this cell type is
Externí odkaz:
https://doaj.org/article/dd3c47c575c046c29dface8c16a37312
Autor:
Chiara Sfogliarini, Giovanna Pepe, Arianna Dolce, Sara Della Torre, Maria Candida Cesta, Marcello Allegretti, Massimo Locati, Elisabetta Vegeto
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Beyond the wide use of tamoxifen in breast cancer chemotherapy due to its estrogen receptor antagonist activity, this drug is being assayed in repurposing strategies against a number of microbial infections. We conducted a literature search on the ev
Externí odkaz:
https://doaj.org/article/3d9ed32578de4f07951bcc0f71d5beeb
Autor:
Giovanna Pepe, Chiara Sfogliarini, Loris Rizzello, Giuseppe Battaglia, Christian Pinna, Gianenrico Rovati, Paolo Ciana, Electra Brunialti, Federica Mornata, Adriana Maggi, Massimo Locati, Elisabetta Vegeto
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112274- (2021)
ABSTRACT: Sex differences in immune-mediated diseases are linked to the activity of estrogens on innate immunity cells, including macrophages. Tamoxifen (TAM) is a selective estrogen receptor modulator (SERM) used in estrogen receptor-alpha (ERα)-de
Externí odkaz:
https://doaj.org/article/a7edf7f586f44f0282507cf6c6d73aa5
Autor:
Gianluca D’Agostino, Marc Artinger, Massimo Locati, Laurent Perez, Daniel F. Legler, Marco E. Bianchi, Curzio Rüegg, Marcus Thelen, Adriano Marchese, Marco B. L. Rocchi, Valentina Cecchinato, Mariagrazia Uguccioni
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The chemokine receptor CXCR4 plays a fundamental role in homeostasis and pathology by orchestrating recruitment and positioning of immune cells, under the guidance of a CXCL12 gradient. The ability of chemokines to form heterocomplexes, enhancing the
Externí odkaz:
https://doaj.org/article/41046b78f9d74b69aceb46234cb3744c