Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Massimo Gianotti"'
β-Amino esters derived from the stereoselective conjugate addition of homochiral lithium N-benzyl-N-α-methyl-4-methoxybenzylamide to α,β-unsaturated esters may be orthogonally mono-N-deprotected under either oxidative or acid-promoted reaction co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2be2aa4d1ae31820f99caa9c72eb042
https://ora.ox.ac.uk/objects/uuid:37c96ddc-c875-45c0-8edd-2ec953d09ff2
https://ora.ox.ac.uk/objects/uuid:37c96ddc-c875-45c0-8edd-2ec953d09ff2
Autor:
Laurie J. Gordon, Anna-Maria Capelli, Laura Zonzini, Manuela Borriello, Romano Di-Fabio, Enrica Granci, Massimo Gianotti, Roberto Arban, Simone Spada, Barbara Bertani, Stefania Faedo, Valeria Zucchelli, Alessandra Pasquarello, Angela Worby, Steven Mark Bromidge
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:7092-7096
5-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}-2(1H)-quinolinones and 3,4-dihydro-2(1H)-quinolinones have been identified with different combinations of 5-HT(1) autoreceptor antagonist and hSerT potencies and excellent rat PK profiles. The avai
Autor:
Colin Philip Leslie, Massimo Gianotti, Corrado Corti, Laura Piccoli, Romano Di Fabio, Mark Wigglesworth, Luigi Piero Stasi, Sonia Delle Fratte, Francesca Pavone
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:5069-5073
A novel imidazobenzazepine template (5a) with potent dual H1/5-HT2A antagonist activity was identified. Application of a zwitterionic approach to this poorly selective and poorly developable starting point successfully delivered a class of high quali
Autor:
Ilaria Sartori, Laura Zonzini, Laurie J. Gordon, Angela Worby, Stefano Fontana, Manuela Borriello, Silvia Bison, Jeannette M. Watson, Steven Mark Bromidge, Giovanna Dal Forno, Colin Philip Leslie, Alessandra Pasquarello, Anna Sava, Luca G. Moccia, Barbara Bertani, Roberto Arban, Daniele Donati, Enrica Granci, Valeria Zucchelli, Paolo Cavanni, Massimo Gianotti, Romano Di-Fabio
Publikováno v:
Journal of Medicinal Chemistry. 53:5827-5843
Bioisoteric replacement of the metabolically labile N-methyl amide group of a series of benzoxazinones with small heterocyclic rings has led to novel series of fused tricyclic benzoxazines which are potent 5-HT1A/B/D receptor antagonists with and wit
Autor:
Steven M, Bromidge, Barbara, Bertani, Manuela, Borriello, Andrea, Bozzoli, Stefania, Faedo, Massimo, Gianotti, Laurie J, Gordon, Matthew, Hill, Valeria, Zucchelli, Jeannette M, Watson, Laura, Zonzini
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2338-2342
8-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones have been identified as highly potent 5-HT(1A/B/D) receptor antagonists with and without additional SerT activity and a high degree of selectivity over hERG potassium channels. Modulation
Autor:
Luca Gentilucci, Serena Fabbroni, Giuliana Cardillo, Alessandra Tolomelli, Massimo Gianotti, Rossana Percacciante
Publikováno v:
Tetrahedron: Asymmetry. 13:1407-1410
The preparation of aziridine-2,2-dicarboxylates via 1,4-addition of N , O -bis(trimethylsilyl)hydroxylamine to α,β-unsaturated malonates in the presence of chiral Lewis acids is reported. Good enantioselectivity was observed for conjugate addition
Autor:
Simona Selva, Giuliana Cardillo, Rossana Perciaccante, Luca Gentilucci, Serena Fabbroni, Massimo Gianotti, Alessandra Tolomelli
Publikováno v:
Tetrahedron: Asymmetry. 13:1411-1415
The absolute configuration of aziridine-2,2-dicarboxylates was determined through their transformation into the corresponding diastereomeric (S)-(−)-α-methylbenzylamido derivatives. The data obtained allows establishment of the stereochemistry of
Autor:
Massimo Gianotti, Daniele Andreotti, Filippo Valente, Davide Casotto, Roberto Profeta, Francesca Pavone, Anna Mingardi, Mario Mattioli
Publikováno v:
Tetrahedron Letters. 52:329-331
A new synthetic pathway to the final compound 1-[(1S)-5’,11’-dihydrospiro[cyclopentane-1,10’-dibenzo[a,d]cyclohepten]-3-yl]-3-azetidinecarboxylic acid (1) was set up. The two preparative chiral HPLC separations needed in the first route were su
Autor:
Alessandra Tolomelli, Giuliana Cardillo, Luca Gentilucci, Massimo Gianotti, Rossana Perciaccante
Publikováno v:
The Journal of Organic Chemistry. 66:8657-8660
Autor:
Steven D. Bull, Massimo Gianotti, Stephen G. Davies, Mario Laderas, Andrew D. Smith, Peter M. Kelly, Luke J. Kotchie, Santiago Delgado-Ballester
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :3112-3121
Lithium N-benzyl-N-α-methyl-4-methoxybenzylamide may be employed as a homochiral ammonia equivalent for the synthesis of homochiral β-haloaryl β-amino acid derivatives via a strategy involving its conjugate addition to α,β-unsaturated β-haloary