Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Massimo Di Nicola"'
Autor:
Alexandra Leary, Paolo A Ascierto, Michele Maio, Georgia Kollia, Jennifer Friedmann, Marina Tschaika, Patrick Schöffski, Jonathan Baden, Neeltje Steeghs, Parul Doshi, Massimo Di Nicola, Jean-Pierre Delord, Iwona Lugowska, Mauricio Burotto, David S P Tan, Anthony Gonçalves, Michael Schenker, Ning Huang, Tudor-Eliade Ciuleanu, Martin Richardet, Lorena Lupinacci, Julieta Grasselli, Jacqueline Vuky, Somasekhar Konduru, Sai Vikram Vemula, Ruta Slepetis, Misena Pacius, Quyen Duong
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 8 (2024)
Background Checkpoint inhibitor therapy has demonstrated overall survival benefit in multiple tumor types. Tumor mutational burden (TMB) is a predictive biomarker for response to immunotherapies. This study evaluated the efficacy of nivolumab+ipilimu
Externí odkaz:
https://doaj.org/article/be397a2c9d104c41b010a59bc9500941
Autor:
Licia Rivoltini, Chiara Camisaschi, Giovanni Fucà, Biagio Paolini, Barbara Vergani, Valeria Beretta, Silvia Damian, Matteo Duca, Sara Cresta, Michele Magni, Biagio Eugenio Leone, Chiara Castelli, Filippo de Braud, Francesca De Santis, Massimo Di Nicola
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract In patients with advanced triple-negative breast cancer (TNBC), translational research efforts are needed to improve the clinical efficacy of immunotherapy with checkpoint inhibitors. Here, we report on the immunological characterization of
Externí odkaz:
https://doaj.org/article/2bb7f6970e0a4904908b7f9f76f21ff0
Autor:
Debbie Robbrecht, Jean‐Jacques Grob, Oliver Bechter, Matteo Simonelli, Bernard Doger, Ivan Borbath, Marcus O. Butler, Tina Cheng, Patricia Martin Romano, Elvire Pons‐Tostivint, Massimo Di Nicola, Giuseppe Curigliano, Min‐Hee Ryu, Alejo Rodriguez‐Vida, Dirk Schadendorf, Elena Garralda, Giovanni Abbadessa, Brigitte Demers, Amele Amrate, Hong Wang, Joon Sang Lee, Robert Pomponio, Rui Wang
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 2, Pp n/a-n/a (2024)
Abstract SAR439459, a ‘second‐generation’ human anti‐transforming growth factor‐beta (TGFβ) monoclonal antibody, inhibits all TGFβ isoforms and improves the antitumor activity of anti‐programmed cell death protein‐1 therapeutics. This
Externí odkaz:
https://doaj.org/article/28412427e6174db093de8737922fa32a
Autor:
Mara Lecchi, Paolo Verderio, Vera Cappelletti, Francesca De Santis, Biagio Paolini, Melissa Monica, Sabina Sangaletti, Serenella Maria Pupa, Marilena Valeria Iorio, Giulia Bianchi, Massimiliano Gennaro, Giovanni Fucà, Filippo De Braud, Elda Tagliabue, Massimo Di Nicola
Publikováno v:
Molecular Oncology, Vol 15, Iss 5, Pp 1345-1357 (2021)
Breast cancer (BC) is a heterogeneous disease in which the tumor microenvironment (TME) seems to impact the clinical outcome. Here, we investigated whether a combination of gene expression signatures relating to both the structural and immune TME asp
Externí odkaz:
https://doaj.org/article/4545c7dc97c346a6b97352acf707038d
Autor:
Rui Wang, Ivan Borbath, Patrícia Martin, Armando Santoro, Bernard Doger, Elena Garralda, Oliver Bechter, Giovanni Abbadessa, Debbie Robbrecht, Grob Jean-Jacques, Butler Marcus, Cheng Tina, Bennouna Jaafar, Massimo Di Nicola, Alejo Rodriguez -Vida, Dirk Schadendof, Brigitte Demers, Amele Amrate, Tun Tun Lin, Manisha Brahmachary, Joon Sange Lee, Joachim Theilhaber, Rob Pomponio
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/88675d694f8d48889bbf1854a78ac83e
Autor:
Filippo de Braud, Francesca De Santis, Roberta Zappasodi, Massimo Di Nicola, Margherita Ambrosini, Michele Magni, Luca Agnelli, Silvia Brich, Francesco Sgambelluri, Roberta Mortarini, Serenella M Pupa, Liliana Devizzi, Paola Matteucci, Antonello Cabras, Andrea Anichini, Alessandro M Gianni
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
We previously published the results of a pilot study showing that vaccination with tumor-loaded dendritic cells (DCs) induced both T and B cell response and produced clinical benefit in the absence of toxicity in patients with relapsed, indolent non-
Externí odkaz:
https://doaj.org/article/f9ca43637fe4422fb209fd32c96031a5
Autor:
Peter Dreger, Paolo Pedrazzoli, Salvatore Siena, Christoph E Heilig, Stefan Fröhling, Massimo Di Nicola, Manuela Badoglio, Myriam Labopin, Simona Secondino, Jürgen Heinz, Emmanuelle Nicolas-Virelizier, Didier Blaise, Clément Korenbaum, Armando Santoro, Mareike Verbeek, William Krüger, Jakob R Passweg, Jose Rifón, Ulrike Koehl, Christian Chabannon
Publikováno v:
ESMO Open, Vol 5, Iss 5 (2020)
Background The role of high-dose chemotherapy with autologous stem cell transplantation (ASCT) in the treatment of soft-tissue sarcoma (STS) remains an unsettled issue. Prospective clinical trials failed to prove a benefit of the procedure but were l
Externí odkaz:
https://doaj.org/article/024631707b254e0887fad07c47174a09
Autor:
Hendrik-Tobias Arkenau, Jean-Yves Douillard, Nicolas Penel, Teresa Amaral, Ahmad Awada, Emiliano Calvo, Viktor Gruenwald, Jose Luis Perez-Gracia, Ruth Vera, Martijn P Lolkema, Gyorgy Bodoky, Massimo Di Nicola, Miguel F Sanmamed
Publikováno v:
ESMO Open, Vol 5, Iss 3 (2020)
During the last years, there has been a dramatic increase in the administrative and bureaucratic burden associated with clinical research, which has clearly had an impact on its overall efficiency and on the activity of clinical investigators and res
Externí odkaz:
https://doaj.org/article/c8d312d3e1a44b40a040f3c31e8a35a2
Autor:
Alessandro Satta, Giulia Grazia, Francesco Caroli, Barbara Frigerio, Massimo Di Nicola, Francesco Raspagliesi, Delia Mezzanzanica, Nadia Zaffaroni, Alessandro Massimo Gianni, Andrea Anichini, Mariangela Figini
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
T-cell-based immunotherapy strategies have profoundly improved the clinical management of several solid tumors and hematological malignancies. A recently developed and promising immunotherapy approach is to redirect polyclonal MHC-unrestricted T lymp
Externí odkaz:
https://doaj.org/article/f64637329ecd4ce3a1e75b4bcc107985
Autor:
Francesco Mainini, Francesca De Santis, Giovanni Fucà, Massimo Di Nicola, Licia Rivoltini, Michael Eccles
Publikováno v:
Cancers, Vol 13, Iss 15, p 3765 (2021)
A number of novel cancer therapies have recently emerged that have rapidly moved from the bench to the clinic. Onco-immunotherapies, such as immune checkpoint blockade inhibitors and adoptive cell therapies, have revolutionized the field, since they
Externí odkaz:
https://doaj.org/article/c3240c400fc344cca5e98b7a248ff83d