Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Massimo Degano"'
Autor:
Anastasia Iatrou, Palash C Maity, Alexandra Theresa Linder, Andreas Agathangelidis, Michela Frenquelli, Raphael Sandaltzopoulos, Massimo Degano, Anastasia Chatzidimitriou, Paolo Ghia, Hassan Jumaa, Kostas Stamatopoulos
Publikováno v:
HemaSphere, Vol 7, p e8483669 (2023)
Externí odkaz:
https://doaj.org/article/03f3c9c556304d8a81ba8c3cdae75343
Autor:
Stefania Zuppone, Chiara Assalini, Claudia Minici, Oronza A. Botrugno, Flavio Curnis, Massimo Degano, Angelo Corti, Francesco Montorsi, Andrea Salonia, Riccardo Vago
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Although toxin may have some advantages compared to chemotherapeutic drugs in cancer therapy, e.g. a potent cytotoxic activity and a reduced risk of resistance, their successful application in the treatments to solid tumors still remains to be fully
Externí odkaz:
https://doaj.org/article/e32562cd4c1948f695e2baa6a239f800
Autor:
Elisa Pesce, Claudia Minici, Jochen Baßler, Ed Hurt, Massimo Degano, Piera Calamita, Stefano Biffo
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/f52f929a627d42f39e9074a05ba066f6
Autor:
Claudia Minici, Maria Gounari, Rudolf Übelhart, Lydia Scarfò, Marcus Dühren-von Minden, Dunja Schneider, Alpaslan Tasdogan, Alabbas Alkhatib, Andreas Agathangelidis, Stavroula Ntoufa, Nicholas Chiorazzi, Hassan Jumaa, Kostas Stamatopoulos, Paolo Ghia, Massimo Degano
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Chronic lymphocytic leukaemia (CLL) is characterized by cell-autonomous B-cell receptor (BcR)-mediated signalling of neoplastic B lymphocytes. Here the authors unveil the structural basis and diversity of activatory homotypic BcR contacts and link th
Externí odkaz:
https://doaj.org/article/d134c066cc4e4ceb916cfd21f5f03500
Autor:
Federica Barzaghi, Federica Minniti, Margherita Mauro, Massimiliano De Bortoli, Rita Balter, Elisa Bonetti, Ada Zaccaron, Virginia Vitale, Maryam Omrani, Matteo Zoccolillo, Immacolata Brigida, Maria Pia Cicalese, Massimo Degano, Michael S. Hershfield, Alessandro Aiuti, Anastasiia V. Bondarenko, Matteo Chinello, Simone Cesaro
Publikováno v:
Frontiers in Immunology, Vol 9 (2019)
Adenosine deaminase 2 (ADA2) deficiency is an auto-inflammatory disease due to mutations in cat eye syndrome chromosome region candidate 1 (CECR1) gene, currently named ADA2. The disease has a wide clinical spectrum encompassing early-onset vasculopa
Externí odkaz:
https://doaj.org/article/47f65f0e0e954a7a959df3bccfcbee78
Autor:
Elisa Pesce, Annarita Miluzio, Lorenzo Turcano, Claudia Minici, Delia Cirino, Piera Calamita, Nicola Manfrini, Stefania Oliveto, Sara Ricciardi, Renata Grifantini, Massimo Degano, Alberto Bresciani, Stefano Biffo
Publikováno v:
Cells, Vol 9, Iss 1, p 172 (2020)
Eukaryotic initiation factor 6 (eIF6) is necessary for the nucleolar biogenesis of 60S ribosomes. However, most of eIF6 resides in the cytoplasm, where it acts as an initiation factor. eIF6 is necessary for maximal protein synthesis downstream of gro
Externí odkaz:
https://doaj.org/article/1564496d7c2b46afb4b6e85ce4b85459
Autor:
Paolo Miotto, Andrea M. Cabibbe, Silke Feuerriegel, Nicola Casali, Francis Drobniewski, Yulia Rodionova, Daiva Bakonyte, Petras Stakenas, Edita Pimkina, Ewa Augustynowicz-Kopeć, Massimo Degano, Alessandro Ambrosi, Sven Hoffner, Mikael Mansjö, Jim Werngren, Sabine Rüsch-Gerdes, Stefan Niemann, Daniela M. Cirillo
Publikováno v:
mBio, Vol 5, Iss 5 (2014)
ABSTRACT Pyrazinamide (PZA) is a prodrug that is converted to pyrazinoic acid by the enzyme pyrazinamidase, encoded by the pncA gene in Mycobacterium tuberculosis. Molecular identification of mutations in pncA offers the potential for rapid detection
Externí odkaz:
https://doaj.org/article/a793c5931b3743058afca8d56f3a8e4d
Autor:
Giacomo Quilici, Matteo Lampis, Giovanna Musco, Valeria Mannella, Elisa Agnese Nigro, Alessandra Boletta, Massimo Degano, Claudia Minici
Publikováno v:
ACS Chemical Biology. 14:1845-1854
Mutations in the NPHP1 gene, coding for human nephrocystin-1 (NPHP1), cause the autosomal recessive disease nephronophthisis, the most common cause of end-stage renal disease in children and adolescents. The function and structure of NPHP1 are still
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e8f50356e805cef9b8cf074ecfc73e
https://doi.org/10.1021/acschembio.9b00582
https://doi.org/10.1021/acschembio.9b00582
Autor:
S. Bertagnoli, Riccardo Vago, Andrea Salonia, Claudia Minici, Massimo Degano, Stefania Zuppone, Francesco Montorsi, C. Assalini, Paola Branduardi, Maria Serena Fabbrini
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
The development of personalized therapies represents an urgent need owing to the high rate of cancer recurrence and systemic toxicity of conventional drugs. So far, targeted toxins have shown promising results as potential therapeutic compounds. Spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fff3cdb3ef84eeb6f2142c441e3d87f6
https://doi.org/10.1038/s41598-020-59313-8
https://doi.org/10.1038/s41598-020-59313-8
Autor:
Valeria Berno, Marco Patrone, Eugenia Cammarota, Massimo Degano, Paola Tornaghi, Davide Mazza
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-12 (2020)
Communications Biology
Communications Biology
The structural plasticity of G-protein coupled receptors (GPCRs) enables the long-range transmission of conformational changes induced by specific orthosteric site ligands and other pleiotropic factors. Here, we demonstrate that the ligand binding ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb93e92ecbdf27921224a4ceec5245f
