Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Massimo Cini"'
Autor:
Vittorio Pinciroli, Massimo Cini, Felicita Greco, Mario Varasi, Arturo Della Torre, Carmela Speciale, Salvatore Toma, Paolo Pevarello, Antonio Pillan, Franco Heidempergher, Marina Marconi
Publikováno v:
Il Farmaco. 54:152-160
A series of pyrrolo[3,2-c]quinoline derivatives were synthesised and evaluated as inhibitors of selected enzymes of the kynurenine pathway. 7-Chloro-3-methyl-1H-pyrrolo[3,2-c]quinoline-4-carboxylic acid (7a) was found to be a relatively potent and se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a53f6f0d4074b8258714c827e372d63
https://doi.org/10.1016/s0014-827x(99)00009-9
https://doi.org/10.1016/s0014-827x(99)00009-9
Autor:
Carmela Speciale, Massimo Cini, Salvatore Toma, R. Bormetti, Paolo Pevarello, Mario Varasi, Antonio Giordani, Felicita Greco
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:2907-2912
Kynurenine 3-hydroxylase (KYN 3-OHase) is a key enzyme in the kynurenine pathway of tryptophan degradation and its inhibition may be an effective mechanism for counteracting neuronal excitotoxic damage. We present here a new class of inhibitors deriv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b80d2f540ecd03f8ba2411cd73b546
https://doi.org/10.1016/s0960-894x(98)00517-4
https://doi.org/10.1016/s0960-894x(98)00517-4
ChemInform Abstract: 4-Phenyl-4-oxo-butanoic Acid Derivatives Inhibitors of Kynurenine 3-Hydroxylase
Autor:
Antonio Giordani, Carmela Speciale, Mario Varasi, Paolo Pevarello, R. Bormetti, Felicita Greco, Salvatore Toma, Massimo Cini
Publikováno v:
ChemInform. 30
Kynurenine 3-hydroxylase (KYN 3-OHase) is a key enzyme in the kynurenine pathway of tryptophan degradation and its inhibition may be an effective mechanism for counteracting neuronal excitotoxic damage. We present here a new class of inhibitors deriv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38bebeb306ae8037727a241a6679b913
https://doi.org/10.1002/chin.199906082
https://doi.org/10.1002/chin.199906082
Autor:
Massimo Cini, Luca Bagnoli
Publikováno v:
La cooperazione sociale nell'area metropolitana fiorentina
This study proposes a reading of the financial statements of co-operatives operating within the Florentine metropolitan area, with a view to underscoring business aspects of a quantitative and monetary nature. The entrepreneurial nature of the co-ope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7aec73a85999291f104c3764f206b02c
https://doi.org/10.26530/oapen_345112
https://doi.org/10.26530/oapen_345112
Autor:
Paolo Pevarello, Philippe Dostert, F Vaghi, Alberto Bonsignori, A Della Torre, Massimo Cini, M. Varasi, M. Meroni, Piero Melloni
Publikováno v:
European Journal of Medicinal Chemistry. 26:207-213
In the search for new antidepressants with a rapid onset of action, fenmetazole analogues, bearing a second phenyl ring in a position previously shown not to be detrimental to affinity and selectivity for the α2-adrenoreceptors, were synthesized in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3180143290f77a706832c22ec907568a
https://doi.org/10.1016/0223-5234(91)90031-h
https://doi.org/10.1016/0223-5234(91)90031-h
Autor:
Patricia Salvati, Massimo Cini, Marina Marconi, Antonio Molinari, Luciano Dho, Giorgio Ukmar, Post Claes, Bruno Rosa
Publikováno v:
Progress in neuro-psychopharmacologybiological psychiatry. 23(4)
1. Kynurenic acid (KYNA) is a kynurenine metabolite and a broad spectrum excitatory amino acid antagonist that has been shown to be neuroprotective in models of cerebral ischemia, when administered exogenously. However, the actual concentration requi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::722ee8e2fe34d9579fc76e81290f38f6
https://pubmed.ncbi.nlm.nih.gov/10390731
https://pubmed.ncbi.nlm.nih.gov/10390731
Publikováno v:
European journal of pharmacology. 315(3)
Kynurenic acid is an endogenous excitatory amino-acid receptor antagonist with neuroprotective and anticonvulsant properties. We demonstrate here that systemic administration of the new and potent kynurenine 3-hydroxylase inhibitor (R,S)-3,4-dichloro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::464d9fdbeffabf68c82c510245d80588
https://pubmed.ncbi.nlm.nih.gov/8982663
https://pubmed.ncbi.nlm.nih.gov/8982663
Autor:
Emma Riva, Antonio Pesenti, A. Bizzi, Tullio Bertani, E. Veneroni, Massimo Cini, Enrico Tavbani, Raimondo Boeri, S. Marchi, Roberto Latini
Publikováno v:
Biochemical Pharmacology. 36:3209-3214
Amiodarone, an antiarrhythmic drug, causes pulmonary fibrosis in some patients during chronic treatment but the mechanism is unknown. We studied the effects of amiodarone on pulmonary biochemistry, morphology and function at doses of 25 and 50 mg/kg/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b52b31752b6b0182de2edd2569df845
https://doi.org/10.1016/0006-2952(87)90635-6
https://doi.org/10.1016/0006-2952(87)90635-6