Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Massimo Bortolotti"'
Autor:
Massimo Bortolotti, Andrea Zanello, Lorenzo Serra, Francesco Biscotti, Letizia Polito, Andrea Bolognesi
Publikováno v:
Stresses, Vol 3, Iss 1, Pp 270-281 (2023)
The most successful alternative to traditional surgery for ocular muscle spasm treatment is the intramuscular injection of botulinum toxin (BTX), which allows the maintenance of the muscle dynamics and the absence of scars. However, the main BTX disa
Externí odkaz:
https://doaj.org/article/137bdb1b70a741b7b89da08a4b703166
Publikováno v:
Antioxidants, Vol 13, Iss 2, p 211 (2024)
Taking into account the patient’s gender is the first step towards more precise and egalitarian medicine. The gender-related divergences observed in purine catabolism and their pathological consequences are good examples of gender medicine differen
Externí odkaz:
https://doaj.org/article/4d13378f54b748b9aa8fc95950497158
Publikováno v:
Toxins, Vol 16, Iss 1, p 1 (2023)
Ribosome-inactivating proteins (RIPs) are plant toxins that were identified for their ability to irreversibly damage ribosomes, thereby causing arrest of protein synthesis and induction of cell death. The RIPs purified from Adenia plants are the most
Externí odkaz:
https://doaj.org/article/046e6b5976134ba6bb9e10e83fbd6a80
Publikováno v:
Advances in Redox Research, Vol 7, Iss , Pp 100055- (2023)
Human xanthine oxidoreductase (XOR) is a multilevel regulated enzyme, which has many physiological functions, but which is also involved in several pathological processes. The contributions of Stirpe and his research group at the University of Bologn
Externí odkaz:
https://doaj.org/article/d1543aab0cb741cca921b69edd8d4208
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Immune checkpoint mechanisms are important molecular cell systems that maintain tolerance toward autoantigens in order to prevent immunity-mediated accidental damage. It is well known that cancer cells may exploit these molecular and cellular mechani
Externí odkaz:
https://doaj.org/article/bd71d34863744363866c7957a77ab3ec
Publikováno v:
Biomedicines, Vol 11, Iss 4, p 1214 (2023)
Saporin is a type 1 ribosome-inactivating protein widely used as toxic payload in the construction of targeted toxins, chimeric molecules formed by a toxic portion linked to a carrier moiety. Among the most used carriers, there are large molecules (m
Externí odkaz:
https://doaj.org/article/6b177eb54b07441d83206cce84285496
Publikováno v:
Redox Biology, Vol 48, Iss , Pp 102195- (2021)
Cardiovascular diseases (CVD) are the leading cause of global mortality and their pathogenesis lies mainly in the atherosclerotic process. There are close connections linking oxidative stress and inflammation to endothelial dysfunction, atheroscleros
Externí odkaz:
https://doaj.org/article/4408fe5b6fd343a3bd633492cf7eaf98
Publikováno v:
Redox Biology, Vol 41, Iss , Pp 101882- (2021)
Human xanthine oxidoreductase (XOR) is a multiple-level regulated enzyme, resulting from a complicated evolutionary process that assigned it many physiological roles. The main XOR activities are: (i) xanthine dehydrogenase (XDH) activity that perform
Externí odkaz:
https://doaj.org/article/8fc031674bd94188a56b077299c8c1bc
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/e0c0ffe7b0cb4e9d99f21877da338279
Autor:
Daniele Mercatelli, Massimo Bortolotti, Vibeke Andresen, André Sulen, Letizia Polito, Bjørn Tore Gjertsen, Andrea Bolognesi
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Stenodactylin, a highly toxic type 2 ribosome-inactivating protein purified from the caudex of Adenia stenodactyla Harms, is a potential anticancer drug candidate. Previous studies demonstrated that stenodactylin induces apoptosis and necroptosis in
Externí odkaz:
https://doaj.org/article/35680d1231d54f88bbc6604c63d3a7bb