Role of CDK4 as prognostic biomarker in Soft Tissue Sarcoma and synergistic effect of its inhibition in dedifferentiated liposarcoma sequential treatment

Autor: Silvia Vanni, Giacomo Miserocchi, Graziana Gallo, Valentina Fausti, Sofia Gabellone, Chiara Liverani, Chiara Spadazzi, Claudia Cocchi, Chiara Calabrese, Giovanni De Luca, Massimo Bassi, Manlio Gessaroli, Nicola Tomasetti, Angelo Campobassi, Federica Pieri, Giorgio Ercolani, Davide Cavaliere, Lorena Gurrieri, Nada Riva, Federica Recine, Toni Ibrahim, Laura Mercatali, Robin Jones, Alessandro De Vita

Publikováno v: Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-4 (2024)

Abstract Soft tissue sarcomas represent an heterogeneous group of rare mesenchymal tumors comprising 1% of all solid malignancies. Among them, liposarcoma is one of the most common histotypes with atypical lipomatous tumor/well differentiated liposar

Externí odkaz: https://doaj.org/article/67e47af7cc474fdabff1ecf9d66a2bd6

Three-dimensional collagen-based scaffold model to study the microenvironment and drug-resistance mechanisms of oropharyngeal squamous cell carcinomas

Autor: Giacomo Miserocchi, Claudia Cocchi, Alessandro De Vita, Chiara Liverani, Chiara Spadazzi, Sebastiano Calpona, Giandomenico Di Menna, Massimo Bassi, Giuseppe Meccariello, Giovanni De Luca, Angelo Campobassi, Maria Maddalena Tumedei, Alberto Bongiovanni, Valentina Fausti, Franco Cotelli, Toni Ibrahim, Laura Mercatali

Publikováno v: Cancer Biology & Medicine, Vol 18, Iss 2, Pp 502-516 (2021)

Objective: Squamous cell carcinoma (SCC) represents the most common histotype of all head and neck malignancies and includes oropharyngeal squamous cell carcinoma (OSCC), a tumor associated with different clinical outcomes and linked to human papillo

Externí odkaz: https://doaj.org/article/b2b4a83cf3894a17815a4a8558ec3d76

Abstract 5993: Dissecting the role of CDK4 in liposarcoma

Autor: Silvia Vanni, Graziana Gallo, Valentina Fausti, Giacomo Miserocchi, Chiara Liverani, Chiara Spadazzi, Claudia Cocchi, Chiara Calabrese, Giovanni De Luca, Massimo Bassi, Manlio Gessaroli, Angelo Campobassi, Federica Pieri, Giorgio Ercolani, Davide Cavaliere, Lorena Gurrieri, Nada Riva, Giovanni Martinelli, Laura Mercatali, Alessandro De Vita

Publikováno v: Cancer Research. 83:5993-5993

Background: Liposarcoma (LPS) encompass one of most common soft tissue sarcoma (STS) histological subtypes accounting for 15% of all cases. They can be divided into four entities including atypical lipomatous tumor or well-differentiated LPS (ALT/WDL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dab535344d50c17823fce6619faeec70
https://doi.org/10.1158/1538-7445.am2023-5993

Three-dimensional collagen-based scaffold model to study the microenvironment and drug-resistance mechanisms of oropharyngeal squamous cell carcinomas

Autor: Toni Ibrahim, Massimo Bassi, Sebastiano Calpona, Giovanni De Luca, Alberto Bongiovanni, Giacomo Miserocchi, Giuseppe Meccariello, Chiara Spadazzi, Giandomenico Di Menna, Maria Maddalena Tumedei, Laura Mercatali, Alessandro De Vita, Chiara Liverani, Franco Cotelli, Claudia Cocchi, Angelo Campobassi, Valentina Fausti

Publikováno v: Cancer Biology & Medicine, Vol 18, Iss 2, Pp 502-516 (2021)
Cancer Biology & Medicine

Objective: Squamous cell carcinoma (SCC) represents the most common histotype of all head and neck malignancies and includes oropharyngeal squamous cell carcinoma (OSCC), a tumor associated with different clinical outcomes and linked to human papillo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c008fa17c6d6b4a2968d2feaa6619aed
https://doi.org/10.20892/j.issn.2095-3941.2020.0482

Deciphering the Genomic Landscape and Pharmacological Profile of Uncommon Entities of Adult Rhabdomyosarcomas

Autor: Chiara Spadazzi, Laura Mercatali, Chiara Liverani, Lorena Gurrieri, Sebastiano Calpona, Anna Maria Ferrari, Giandomenico Di Menna, Federica Pieri, Chiara Domizio, Toni Ibrahim, Enrico Cavagna, Angelo Campobassi, Alessandro De Vita, Valentina Fausti, Nada Riva, Giovanni De Luca, Silvia Angela Debonis, Federica Recine, Anna Farnedi, Eugenia Franchini, Manlio Gessaroli, Claudia Cocchi, Giacomo Miserocchi, Silvia Vanni, Massimo Bassi, Alberto Bongiovanni

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 11564, p 11564 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 21

Adult rhabdomyosarcoma (RMS) represents an uncommon entity with an incidence of less than 3% of all soft tissue sarcomas (STS). Consequently, the natural history and the clinical management of this disease are infrequently reported. In order to fill

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c34cafac1d04aad9f786ffbdd64f34a
https://www.mdpi.com/1422-0067/22/21/11564