Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Massimo, Pasqualetti"'
Autor:
Giacomo Maddaloni, Noemi Barsotti, Sara Migliarini, Martina Giordano, Serena Nazzi, Marta Picchi, Francesco Errico, Alessandro Usiello, Massimo Pasqualetti
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6475 (2024)
Physiology and behavior are structured temporally to anticipate daily cycles of light and dark, ensuring fitness and survival. Neuromodulatory systems in the brain—including those involving serotonin and dopamine—exhibit daily oscillations in neu
Externí odkaz:
https://doaj.org/article/c8c77b30a652481ca2c77e6aecfac9a7
Autor:
Barbara Lombardo, Marco Pagani, Arianna De Rosa, Marcella Nunziato, Sara Migliarini, Martina Garofalo, Marta Terrile, Valeria D’Argenio, Alberto Galbusera, Tommaso Nuzzo, Annaluisa Ranieri, Andrea Vitale, Eleonora Leggiero, Anna Di Maio, Noemi Barsotti, Ugo Borello, Francesco Napolitano, Alessandra Mandarino, Marco Carotenuto, Uriel Heresco-Levy, Massimo Pasqualetti, Paolo Malatesta, Alessandro Gozzi, Francesco Errico, Francesco Salvatore, Lucio Pastore, Alessandro Usiello
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract The D-aspartate oxidase (DDO) gene encodes the enzyme responsible for the catabolism of D-aspartate, an atypical amino acid enriched in the mammalian brain and acting as an endogenous NMDA receptor agonist. Considering the key role of NMDA r
Externí odkaz:
https://doaj.org/article/7e8f008da6d942f7b332be344650f0ca
Autor:
Polina Kameneva, Victoria I. Melnikova, Maria Eleni Kastriti, Anastasia Kurtova, Emil Kryukov, Aliia Murtazina, Louis Faure, Irina Poverennaya, Artem V. Artemov, Tatiana S. Kalinina, Nikita V. Kudryashov, Michael Bader, Jan Skoda, Petr Chlapek, Lucie Curylova, Lukas Sourada, Jakub Neradil, Marketa Tesarova, Massimo Pasqualetti, Patricia Gaspar, Vasily D. Yakushov, Boris I. Sheftel, Tomas Zikmund, Jozef Kaiser, Kaj Fried, Natalia Alenina, Elena E. Voronezhskaya, Igor Adameyko
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Adrenal glands are major organs regulating stress response., Melnikova et al., show that local release of serotonin limits adrenalin-producing cell number during rodent development, a mechanism which has implications for neuroblastoma development and
Externí odkaz:
https://doaj.org/article/ca903ec136424382bd20c84f80eea462
Autor:
Federico Rocchi, Carola Canella, Shahryar Noei, Daniel Gutierrez-Barragan, Ludovico Coletta, Alberto Galbusera, Alexia Stuefer, Stefano Vassanelli, Massimo Pasqualetti, Giuliano Iurilli, Stefano Panzeri, Alessandro Gozzi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Pathological perturbation affects whole brain network activity. Here the authors show in mice that cortical inactivation unexpectedly results in increased fMRI connectivity between the manipulated regions and its direct axonal targets.
Externí odkaz:
https://doaj.org/article/34340a6ddc7e440f8ca5c87f67b0192c
Autor:
Marco Pagani, Noemi Barsotti, Alice Bertero, Stavros Trakoshis, Laura Ulysse, Andrea Locarno, Ieva Miseviciute, Alessia De Felice, Carola Canella, Kaustubh Supekar, Alberto Galbusera, Vinod Menon, Raffaella Tonini, Gustavo Deco, Michael V. Lombardo, Massimo Pasqualetti, Alessandro Gozzi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Autism spectrum disorder (ASD) is characterised by synaptic surplus and atypical functional connectivity. Here, the authors show that synaptic pathology in Tsc2 haploinsufficient mice is associated with autism-like behavior and cortico-striatal hyper
Externí odkaz:
https://doaj.org/article/70359fada3144b60afebb40b9d37244f
Autor:
Federica Campanelli, Gioia Marino, Noemi Barsotti, Giuseppina Natale, Valeria Calabrese, Antonella Cardinale, Veronica Ghiglieri, Giacomo Maddaloni, Alessandro Usiello, Paolo Calabresi, Massimo Pasqualetti, Barbara Picconi
Publikováno v:
Neurobiology of Disease, Vol 158, Iss , Pp 105448- (2021)
Introduction: Plasticity at corticostriatal synapses is a key substrate for a variety of brain functions – including motor control, learning and reward processing – and is often disrupted in disease conditions. Despite intense research pointing t
Externí odkaz:
https://doaj.org/article/37288ac3a0b540c29c16be6e96e321ba
Autor:
Didi Lamers, Silvia Landi, Roberta Mezzena, Laura Baroncelli, Vinoshene Pillai, Federica Cruciani, Sara Migliarini, Sara Mazzoleni, Massimo Pasqualetti, Maria Passafaro, Silvia Bassani, Gian Michele Ratto
Publikováno v:
Cells, Vol 11, Iss 12, p 1939 (2022)
PCDH19 epilepsy (DEE9) is an X-linked syndrome associated with cognitive and behavioral disturbances. Since heterozygous females are affected, while mutant males are spared, it is likely that DEE9 pathogenesis is related to disturbed cell-to-cell com
Externí odkaz:
https://doaj.org/article/6e9f74216e554b00807f8a94b5555dcb
Autor:
Paola Bonsi, Giulia Ponterio, Valentina Vanni, Annalisa Tassone, Giuseppe Sciamanna, Sara Migliarini, Giuseppina Martella, Maria Meringolo, Benjamin Dehay, Evelyne Doudnikoff, Venetia Zachariou, Rose E Goodchild, Nicola B Mercuri, Marcello D'Amelio, Massimo Pasqualetti, Erwan Bezard, Antonio Pisani
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 1, Pp 1-19 (2018)
Abstract Dopamine D2 receptor signaling is central for striatal function and movement, while abnormal activity is associated with neurological disorders including the severe early‐onset DYT1 dystonia. Nevertheless, the mechanisms that regulate D2 r
Externí odkaz:
https://doaj.org/article/aead3905e88349bb9ef74acccad80c03
Autor:
Sara Migliarini, Silvia Scaricamazza, Cristiana Valle, Alberto Ferri, Massimo Pasqualetti, Elisabetta Ferraro
Publikováno v:
Brain Sciences, Vol 11, Iss 6, p 807 (2021)
Amyotrophic lateral sclerosis (ALS) is characterized by the progressive degeneration of spinal motor neurons as well as corticospinal (CSN) large pyramidal neurons within cortex layer V. An intense microglia immune response has been associated with b
Externí odkaz:
https://doaj.org/article/2155201812714d229edd158c2688b69c
Autor:
Andrea Giorgi, Sara Migliarini, Alberto Galbusera, Giacomo Maddaloni, Maddalena Mereu, Giulia Margiani, Marta Gritti, Silvia Landi, Francesco Trovato, Sine Mandrup Bertozzi, Andrea Armirotti, Gian Michele Ratto, Maria Antonietta De Luca, Raffaella Tonini, Alessandro Gozzi, Massimo Pasqualetti
Publikováno v:
Cell Reports, Vol 21, Iss 4, Pp 910-918 (2017)
Summary: Serotonin-producing neurons profusely innervate brain regions via long-range projections. However, it remains unclear whether and how endogenous serotonergic transmission specifically influences regional or global functional activity. We com
Externí odkaz:
https://doaj.org/article/3d2da61cd386432ca67dab2b5837c76d