Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Massimo, Lopes"'
Autor:
Diego Dibitetto, Martin Liptay, Francesca Vivalda, Hülya Dogan, Ewa Gogola, Martín González Fernández, Alexandra Duarte, Jonas A. Schmid, Morgane Decollogny, Paola Francica, Sara Przetocka, Stephen T. Durant, Josep V. Forment, Ismar Klebic, Myriam Siffert, Roebi de Bruijn, Arne N. Kousholt, Nicole A. Marti, Martina Dettwiler, Claus S. Sørensen, Jean-Christophe Tille, Manuela Undurraga, Intidhar Labidi-Galy, Massimo Lopes, Alessandro A. Sartori, Jos Jonkers, Sven Rottenberg
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Histone H2AX plays a key role in DNA damage signalling in the surrounding regions of DNA double-strand breaks (DSBs). In response to DNA damage, H2AX becomes phosphorylated on serine residue 139 (known as γH2AX), resulting in the recruitmen
Externí odkaz:
https://doaj.org/article/a6af7a0f6d3e43499e0bd7b907be1211
Autor:
Maria Dilia Palumbieri, Chiara Merigliano, Daniel González-Acosta, Danina Kuster, Jana Krietsch, Henriette Stoy, Thomas von Känel, Svenja Ulferts, Bettina Welter, Joël Frey, Cyril Doerdelmann, Andrea Sanchi, Robert Grosse, Irene Chiolo, Massimo Lopes
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Cells rapidly respond to replication stress actively slowing fork progression and inducing fork reversal. How replication fork plasticity is achieved in the context of nuclear organization is currently unknown. Using nuclear actin probes in
Externí odkaz:
https://doaj.org/article/9ce0187fdcd948fb8a159bba559a5fee
Autor:
Mattheus H. E. Wildschut, Julien Mena, Cyril Dördelmann, Marc van Oostrum, Benjamin D. Hale, Jens Settelmeier, Yasmin Festl, Veronika Lysenko, Patrick M. Schürch, Alexander Ring, Yannik Severin, Michael S. Bader, Patrick G. A. Pedrioli, Sandra Goetze, Audrey van Drogen, Stefan Balabanov, Radek C. Skoda, Massimo Lopes, Bernd Wollscheid, Alexandre P. A. Theocharides, Berend Snijder
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Myelofibrosis is a hematopoietic stem cell disorder belonging to the myeloproliferative neoplasms. Myelofibrosis patients frequently carry driver mutations in either JAK2 or Calreticulin (CALR) and have limited therapeutic options. Here, we
Externí odkaz:
https://doaj.org/article/be42116607d44feb831a5d12924ccd1b
Autor:
Laure-Alix Clerbaux, Pierre Cordier, Nina Desboeufs, Kristian Unger, Peter Leary, Gabriel Semere, Yannick Boege, Lap Kwan Chan, Chantal Desdouets, Massimo Lopes, Achim Weber
Publikováno v:
JHEP Reports, Vol 5, Iss 10, Pp 100838- (2023)
Background & Aims: Mcl-1, an antiapoptotic protein overexpressed in many tumours, including hepatocellular carcinoma (HCC), represents a promising target for cancer treatment. Although Mcl-1 non-apoptotic roles might critically influence the therapeu
Externí odkaz:
https://doaj.org/article/5f8d2726cb3b4e978c92f8e81851c77a
Autor:
Martin Andrs, Henriette Stoy, Barbora Boleslavska, Nagaraja Chappidi, Radhakrishnan Kanagaraj, Zuzana Nascakova, Shruti Menon, Satyajeet Rao, Anna Oravetzova, Jana Dobrovolna, Kalpana Surendranath, Massimo Lopes, Pavel Janscak
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Excessive oxidative stress is widely perceived as a key factor in cancer progression. Here, the authors reveal that oxidative stress induces transcription-dependent replication fork stalling that appears to be a major source of chromosomal rearrangem
Externí odkaz:
https://doaj.org/article/745c0a072ad8422ca874cba769fe660b
Autor:
Matteo Berti, Federico Teloni, Sofija Mijic, Sebastian Ursich, Jevgenij Fuchs, Maria Dilia Palumbieri, Jana Krietsch, Jonas A. Schmid, Edwige B. Garcin, Stéphanie Gon, Mauro Modesti, Matthias Altmeyer, Massimo Lopes
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Replication stress has been associated with transient remodelling of replication intermediates into reversed forks, followed by efficient fork restart. Here the authors systematically analyse the role of RAD51 paralogs in these transactions, providin
Externí odkaz:
https://doaj.org/article/46eeddebb333460895c7cc3055c262ef
Autor:
Lukas Hafner, Aleksandra Lezaja, Xu Zhang, Laure Lemmens, Maksym Shyian, Benjamin Albert, Cindy Follonier, Jose Manuel Nunes, Massimo Lopes, David Shore, Stefano Mattarocci
Publikováno v:
Cell Reports, Vol 23, Iss 4, Pp 983-992 (2018)
Summary: The Saccharomyces cerevisiae telomere-binding protein Rif1 plays an evolutionarily conserved role in control of DNA replication timing by promoting PP1-dependent dephosphorylation of replication initiation factors. However, ScRif1 binding ou
Externí odkaz:
https://doaj.org/article/d5456f381b5b400bb0c531535c844a05
Autor:
Sofija Mijic, Ralph Zellweger, Nagaraja Chappidi, Matteo Berti, Kurt Jacobs, Karun Mutreja, Sebastian Ursich, Arnab Ray Chaudhuri, Andre Nussenzweig, Pavel Janscak, Massimo Lopes
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
BRCA2 is involved in both homologous recombination (HR) and the protection of stalled replication forks from degradation. Here the authors reveal how HR factors cooperate in fork remodeling, showing that BRCA2 supports RAD51 loading on the regressed
Externí odkaz:
https://doaj.org/article/37f10f169bf74902a273599741eefa33
Publikováno v:
Cell Reports, Vol 27, Iss 9, Pp 2558-2566.e4 (2019)
Summary: RIF1 is a multifunctional protein implicated in controlling DNA replication and repair. Here, we show that human RIF1 protects nascent DNA from over-degradation at stalled replication forks. The major nuclease resecting nascent DNA in the ab
Externí odkaz:
https://doaj.org/article/dc051ce3ec77403f849dc8b2fb74c710
Autor:
Diego Dibitetto, Martin Liptay, Francesca Vivalda, Ewa Gogola, Hulya Dogan, Martín G. Fernández, Alexandra Duarte, Jonas A. Schmid, Stephen T. Durant, Josep V. Forment, Ismar Klebic, Myriam Siffert, Roebi de Bruijn, Arne N. Kousholt, Nicole A. Marti, Martina Dettwiler, Claus S. Sørensen, Massimo Lopes, Alessandro A. Sartori, Jos Jonkers, Sven Rottenberg
Histone H2AX plays a key role in DNA damage signalling in the surrounding regions of DNA double-strand breaks (DSBs)1,2. In response to DNA damage, H2AX becomes phosphorylated on serine residue 139 (known as γH2AX), resulting in the recruitment of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::175ac711ecfb0ec05959a4002e1d3ac8
https://doi.org/10.1101/2023.05.22.541781
https://doi.org/10.1101/2023.05.22.541781
