Zobrazeno 1 - 10
of 823
pro vyhledávání: '"Massimo, Loda"'
Canonical androgen response element motifs are tumor suppressive regulatory elements in the prostate
Autor:
Xuanrong Chen, Michael A. Augello, Deli Liu, Kevin Lin, Alex Hakansson, Martin Sjöström, Francesca Khani, Lesa D. Deonarine, Yang Liu, Jaida Travascio-Green, Jiansheng Wu, Un In Chan, Jude Owiredu, Massimo Loda, Felix Y. Feng, Brian D. Robinson, Elai Davicioni, Andrea Sboner, Christopher E. Barbieri
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The androgen receptor (AR) is central in prostate tissue identity and differentiation, and controls normal growth-suppressive, prostate-specific gene expression. It also drives prostate tumorigenesis when hijacked for oncogenic transcription
Externí odkaz:
https://doaj.org/article/07a68e6011a946bc9d120ecc4b67fc67
Autor:
Guilherme Henrique Tamarindo, Caroline Fidalgo Ribeiro, Alana Della Torre Silva, Alex Castro, Ícaro Putinhon Caruso, Fátima Pereira Souza, Sebastião Roberto Taboga, Massimo Loda, Rejane Maira Góes
Publikováno v:
Cancer & Metabolism, Vol 12, Iss 1, Pp 1-16 (2024)
Abstract Background Prostate cancer (PCa) shows a rewired metabolism featuring increased fatty acid uptake and synthesis via de novo lipogenesis, both sharply related to mitochondrial physiology. The docosahexaenoic acid (DHA) is an omega-3 polyunsat
Externí odkaz:
https://doaj.org/article/c168afd2838e45f8a054c0b7f1a802f5
Autor:
Hubert Pakula, Mohamed Omar, Ryan Carelli, Filippo Pederzoli, Giuseppe Nicolò Fanelli, Tania Pannellini, Fabio Socciarelli, Lucie Van Emmenis, Silvia Rodrigues, Caroline Fidalgo-Ribeiro, Pier Vitale Nuzzo, Nicholas J. Brady, Wikum Dinalankara, Madhavi Jere, Itzel Valencia, Christopher Saladino, Jason Stone, Caitlin Unkenholz, Richard Garner, Mohammad K. Alexanderani, Francesca Khani, Francisca Nunes de Almeida, Cory Abate-Shen, Matthew B. Greenblatt, David S. Rickman, Christopher E. Barbieri, Brian D. Robinson, Luigi Marchionni, Massimo Loda
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract In the complex tumor microenvironment (TME), mesenchymal cells are key players, yet their specific roles in prostate cancer (PCa) progression remain to be fully deciphered. This study employs single-cell RNA sequencing to delineate molecular
Externí odkaz:
https://doaj.org/article/f358a6f85a6c4b2189686dbb0cfa358f
Autor:
Kazzem Gheybi, Naledi Mmekwa, Maphuti Tebogo Lebelo, Sean M. Patrick, Raymond Campbell, Mukudeni Nenzhelele, Pamela X. Y. Soh, Muvhulawa Obida, Massimo Loda, Joyce Shirindi, Eboneé N. Butler, Shingai B. A. Mutambirwa, M. S. Riana Bornman, Vanessa M. Hayes
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Prostate cancer (PCa) is a significant health burden in Sub-Saharan Africa, with mortality rates loosely linked to African ancestry. Yet studies aimed at identifying contributing risk factors are lacking within the continent and as such excl
Externí odkaz:
https://doaj.org/article/d0fce8dd31414749a19a6f3cfa8336a2
Autor:
Elisa Benedetti, Kelsey Chetnik, Thomas Flynn, Christopher E. Barbieri, Douglas S. Scherr, Massimo Loda, Jan Krumsiek
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-8 (2023)
Abstract Prostate cancer is the second most common cancer in men and affects 1 in 9 men in the United States. Early screening for prostate cancer often involves monitoring levels of prostate-specific antigen (PSA) and performing digital rectal exams.
Externí odkaz:
https://doaj.org/article/d0a20e13995d4a0ca46dac4e068bf0ec
Autor:
Sandy Figiel, Wencheng Yin, Dimitrios Doultsinos, Andrew Erickson, Ninu Poulose, Reema Singh, Anette Magnussen, Thineskrishna Anbarasan, Renuka Teague, Mengxiao He, Joakim Lundeberg, Massimo Loda, Clare Verrill, Richard Colling, Pelvender S. Gill, Richard J. Bryant, Freddie C. Hamdy, Dan J. Woodcock, Ian G. Mills, Olivier Cussenot, Alastair D. Lamb
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-5 (2023)
Abstract Genetic signatures have added a molecular dimension to prognostics and therapeutic decision-making. However, tumour heterogeneity in prostate cancer and current sampling methods could confound accurate assessment. Based on previously publish
Externí odkaz:
https://doaj.org/article/586aa75e487c4ec0a28a445500a1ab30
Autor:
Andrés Camacho, Fatima Salah, Camden P. Bay, Jonathan Waring, Renato Umeton, Michelle S. Hirsch, Alexander P. Cole, Adam S. Kibel, Massimo Loda, Clare M. Tempany, Fiona M. Fennessy
Publikováno v:
BJUI Compass, Vol 4, Iss 4, Pp 473-481 (2023)
Abstract Rationale and objectives The study aims to propose an optimal workflow in patients with a PI‐RADS 3 (PR‐3) assessment category (AC) through determining the timing and type of pathology interrogation used for the detection of clinically s
Externí odkaz:
https://doaj.org/article/3b8230abaeff42dfbb3c80fcff5d522a
Autor:
Xintao Qiu, Nadia Boufaied, Tarek Hallal, Avery Feit, Anna de Polo, Adrienne M. Luoma, Walaa Alahmadi, Janie Larocque, Giorgia Zadra, Yingtian Xie, Shengqing Gu, Qin Tang, Yi Zhang, Sudeepa Syamala, Ji-Heui Seo, Connor Bell, Edward O’Connor, Yang Liu, Edward M. Schaeffer, R. Jeffrey Karnes, Sheila Weinmann, Elai Davicioni, Colm Morrissey, Paloma Cejas, Leigh Ellis, Massimo Loda, Kai W. Wucherpfennig, Mark M. Pomerantz, Daniel E. Spratt, Eva Corey, Matthew L. Freedman, X. Shirley Liu, Myles Brown, Henry W. Long, David P. Labbé
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The role of MYC in transcriptional reprogramming in prostate cancer remains poorly characterized. Here, MYC overexpression antagonizes the canonical AR transcriptional program leading to prostate tumor initiation and progression by disrupting transcr
Externí odkaz:
https://doaj.org/article/bc90d144fd374a6387fda7079a332f9f
Autor:
Aishwarya Gondane, Samuel Girmay, Alma Helevä, Satu Pallasaho, Massimo Loda, Harri M. Itkonen
Publikováno v:
Journal of Biomedical Science, Vol 29, Iss 1, Pp 1-12 (2022)
Abstract Background Transcription, metabolism and DNA damage response are tightly regulated to preserve the genomic integrity, and O-GlcNAc transferase (OGT) is positioned to connect the three. Prostate cancer is the most common cancer in men, and an
Externí odkaz:
https://doaj.org/article/3795e5a214124a5dbb301896e57e4916
Autor:
Stefano Cacciatore, Martha Wium, Cristina Licari, Aderonke Ajayi-Smith, Lorenzo Masieri, Chanelle Anderson, Azola Samkele Salukazana, Lisa Kaestner, Marco Carini, Giuseppina M. Carbone, Carlo V. Catapano, Massimo Loda, Towia A. Libermann, Luiz F. Zerbini
Publikováno v:
Cancer & Metabolism, Vol 9, Iss 1, Pp 1-14 (2021)
Abstract Background Men with African ancestry are more likely to develop aggressive prostate cancer (PCa) and to die from this disease. The study of PCa in the South African population represents an opportunity for biomedical research due to the high
Externí odkaz:
https://doaj.org/article/455b5f98b8da4e75a5af428d053f1584