Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Massimiliano Tognolini"'
Autor:
Helison R. P. Carmo, Isabella Bonilha, Joaquim Barreto, Massimiliano Tognolini, Ilaria Zanotti, Andrei C. Sposito
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 1290 (2024)
Despite significant therapeutic advancements, morbidity and mortality following myocardial infarction (MI) remain unacceptably high. This clinical challenge is primarily attributed to two significant factors: delayed reperfusion and the myocardial in
Externí odkaz:
https://doaj.org/article/b56bd950b1df4361a8ce6626b6f81e43
Autor:
Claudio Festuccia, Miriam Corrado, Alessandra Rossetti, Riccardo Castelli, Alessio Lodola, Giovanni Luca Gravina, Massimiliano Tognolini, Carmine Giorgio
Publikováno v:
Pharmaceuticals, Vol 16, Iss 10, p 1452 (2023)
The Eph kinases are the largest receptor tyrosine kinases (RTKs) family in humans. PC3 human prostate adenocarcinoma cells are a well-established model for studying Eph–ephrin pharmacology as they naturally express a high level of EphA2, a promisin
Externí odkaz:
https://doaj.org/article/3a9195acd46340b580e53587f6f6d3b0
Autor:
Lorenzo Guidetti, Riccardo Castelli, Laura Scalvini, Francesca Ferlenghi, Miriam Corrado, Carmine Giorgio, Massimiliano Tognolini, Alessio Lodola
Publikováno v:
Pharmaceuticals, Vol 15, Iss 2, p 137 (2022)
The role of the Eph-ephrin system in the etiology of pathological conditions has been consolidated throughout the years. In this context, approaches directed against this signaling system, intended to modulate its activity, can be strategic therapeut
Externí odkaz:
https://doaj.org/article/0b82201a259e4962b13fbf700c20e7b4
Autor:
Francesca Ferlenghi, Carmine Giorgio, Matteo Incerti, Lorenzo Guidetti, Paola Chiodelli, Marco Rusnati, Massimiliano Tognolini, Federica Vacondio, Marco Mor, Alessio Lodola
Publikováno v:
Pharmaceuticals, Vol 15, Iss 1, p 41 (2021)
UniPR129, an L-β-homotryptophan conjugate of the secondary bile acid lithocholic acid (LCA), acts as an effective protein-protein interaction (PPI) inhibitor of the Eph–ephrin system but suffers from a poor oral bioavailability in mice. To improve
Externí odkaz:
https://doaj.org/article/ec73d24cb22a4f48a3490411fe0f340b
Autor:
Andrea Grandi, Irene Zini, Simone Palese, Carmine Giorgio, Massimiliano Tognolini, Francesco Marchesani, Stefano Bruno, Lisa Flammini, Anna Maria Cantoni, Riccardo Castelli, Alessio Lodola, Antonella Fusari, Elisabetta Barocelli, Simona Bertoni
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Besides their long-known critical role in embryonic growth and in cancer development and progression, erythropoietin-producing hepatocellular carcinoma type B (EphB) receptor tyrosine kinases and their ephrin-B ligands are involved in the modulation
Externí odkaz:
https://doaj.org/article/2fb3581907414d20b981e09761143397
Autor:
Carmine Giorgio, Marika Allodi, Simone Palese, Andrea Grandi, Massimiliano Tognolini, Riccardo Castelli, Alessio Lodola, Lisa Flammini, Anna Maria Cantoni, Elisabetta Barocelli, Simona Bertoni
Publikováno v:
Pharmaceuticals, Vol 14, Iss 6, p 502 (2021)
Eph receptors, comprising A and B classes, interact with cell-bound ephrins generating bidirectional signaling. Although mainly related to carcinogenesis and organogenesis, the role of Eph/ephrin system in inflammation is growingly acknowledged. Rece
Externí odkaz:
https://doaj.org/article/d6fbab9fcfe94399b7729865e028006f
Autor:
Katsuaki Ieguchi, Takeshi Tomita, Toshifumi Takao, Tsutomu Omori, Taishi Mishima, Isao Shimizu, Massimiliano Tognolini, Alessio Lodola, Takuya Tsunoda, Shinichi Kobayashi, Satoshi Wada, Yoshiro Maru
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5, p 2480 (2021)
Accumulating evidence indicates that an elevated ephrin-A1 expression is positively correlated with a worse prognosis in some cancers such as colon and liver cancer. The detailed mechanism of an elevated ephrin-A1 expression in a worse prognosis stil
Externí odkaz:
https://doaj.org/article/f2304fca56164d208500e15cba0cc1f6
Autor:
Miriam Corrado, Carmine Giorgio, Elisabetta Barocelli, Giuseppe Vittucci Marzetti, Anna Maria Cantoni, Rosanna Di Lecce, Matteo Incerti, Riccardo Castelli, Alessio Lodola, Massimiliano Tognolini
Publikováno v:
Pharmaceuticals, Vol 13, Iss 4, p 69 (2020)
The Eph receptors are the largest receptors tyrosine kinases (RTKs) family in humans and together with ephrin ligands constitute a complex cellular communication system often dysregulated in many tumors. The role of the Eph-ephrin system in colorecta
Externí odkaz:
https://doaj.org/article/eb808453faf5442e9d1e55ff869fb247
Autor:
Donatella Callegari, Daniele Pala, Laura Scalvini, Massimiliano Tognolini, Matteo Incerti, Silvia Rivara, Marco Mor, Alessio Lodola
Publikováno v:
Molecules, Vol 20, Iss 9, Pp 17132-17151 (2015)
The EphA2 receptor and its ephrin-A1 ligand form a key cell communication system, which has been found overexpressed in many cancer types and involved in tumor growth. Recent medicinal chemistry efforts have identified bile acid derivatives as low mi
Externí odkaz:
https://doaj.org/article/353d2a5af94849f5ad3490800bd1a22e
Autor:
Alessio Lodola, Silvia Rivara, Elisabetta Barocelli, Francesca De Franco, Paola Vicini, Antimo Gioiello, Carmine Giorgio, Iftiin Hassan-Mohamed, Riccardo Castelli, Daniele Pala, Matteo Incerti, Marco Mor, Massimiliano Tognolini, Simonetta Russo
Publikováno v:
Molecules, Vol 18, Iss 10, Pp 13043-13060 (2013)
The Eph–ephrin system plays a critical role in tumor growth and vascular functions during carcinogenesis. We had previously identified cholanic acid as a competitive and reversible EphA2 antagonist able to disrupt EphA2-ephrinA1 interaction and to
Externí odkaz:
https://doaj.org/article/f84fc8073c5b4103a212dfea3999704e