Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Massimiliano Caiazzo"'
Autor:
Stefania Douka, Vasilis Papamoschou, Monica Raimo, Enrico Mastrobattista, Massimiliano Caiazzo
Publikováno v:
Pharmaceutics, Vol 16, Iss 9, p 1143 (2024)
Natural killer (NK) cells have recently gained popularity as an alternative for cancer immunotherapy. Adoptive cell transfer employing NK cells offers a safer therapeutic option compared to T-cell-based therapies, due to their significantly lower tox
Externí odkaz:
https://doaj.org/article/25440d46c8e74bb5b564a5df7c48954e
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Many diseases of the central nervous system are age-associated and do not directly result from genetic mutations. These include late-onset neurodegenerative diseases (NDDs), which represent a challenge for biomedical research and drug development due
Externí odkaz:
https://doaj.org/article/9d23588c517b4edbbd7c9287d142b118
Autor:
Francesco Della Valle, Manjula P. Thimma, Massimiliano Caiazzo, Salvatore Pulcrano, Mirko Celii, Sabir A. Adroub, Peng Liu, Gregorio Alanis-Lobato, Vania Broccoli, Valerio Orlando
Publikováno v:
Stem Cell Reports, Vol 14, Iss 1, Pp 60-74 (2020)
Summary: In mammals, LINE-1 (L1) retrotransposons constitute between 15% and 20% of the genome. Although only a few copies have retained the ability to retrotranspose, evidence in brain and differentiating pluripotent cells indicates that L1 retrotra
Externí odkaz:
https://doaj.org/article/5b877dab7e3747c58a1c35b460267621
Autor:
Salvatore Pulcrano, Roberto De Gregorio, Claudia De Sanctis, Laura Lahti, Carla Perrone-Capano, Donatella Ponti, Umberto di Porzio, Thomas Perlmann, Massimiliano Caiazzo, Floriana Volpicelli, Gian Carlo Bellenchi
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 6961 (2022)
The development of midbrain dopaminergic (DA) neurons requires a fine temporal and spatial regulation of a very specific gene expression program. Here, we report that during mouse brain development, the microRNA (miR-) 204/211 is present at a high le
Externí odkaz:
https://doaj.org/article/2e6e1d43887349c980e46c0a694c29c2
Autor:
Emilia Pascale, Carmen Caiazza, Martina Paladino, Silvia Parisi, Fabiana Passaro, Massimiliano Caiazzo
Publikováno v:
Cells, Vol 11, Iss 6, p 940 (2022)
Cell reprogramming is a groundbreaking technology that, in few decades, generated a new paradigm in biomedical science. To date we can use cell reprogramming to potentially generate every cell type by converting somatic cells and suitably modulating
Externí odkaz:
https://doaj.org/article/c18fe1a8a884436ca798b392ab8d4549
Autor:
Giulia Barbagiovanni, Pierre-Luc Germain, Michael Zech, Sina Atashpaz, Pietro Lo Riso, Agnieszka D’Antonio-Chronowska, Erika Tenderini, Massimiliano Caiazzo, Sylvia Boesch, Robert Jech, Bernhard Haslinger, Vania Broccoli, Adrian Francis Stewart, Juliane Winkelmann, Giuseppe Testa
Publikováno v:
Cell Reports, Vol 25, Iss 4, Pp 988-1001 (2018)
Summary: Transdifferentiation of fibroblasts into induced neuronal cells (iNs) by the neuron-specific transcription factors Brn2, Myt1l, and Ascl1 is a paradigmatic example of inter-lineage conversion across epigenetically distant cells. Despite trem
Externí odkaz:
https://doaj.org/article/b9329bcbac7549bcb1e637f2641b835e
Autor:
Roberto De Gregorio, Salvatore Pulcrano, Claudia De Sanctis, Floriana Volpicelli, Ezia Guatteo, Lars von Oerthel, Emanuele Claudio Latagliata, Roberta Esposito, Rosa Maria Piscitelli, Carla Perrone-Capano, Valerio Costa, Dario Greco, Stefano Puglisi-Allegra, Marten P. Smidt, Umberto di Porzio, Massimiliano Caiazzo, Nicola Biagio Mercuri, Meng Li, Gian Carlo Bellenchi
Publikováno v:
Stem Cell Reports, Vol 10, Iss 4, Pp 1237-1250 (2018)
Summary: The differentiation of dopaminergic neurons requires concerted action of morphogens and transcription factors acting in a precise and well-defined time window. Very little is known about the potential role of microRNA in these events. By per
Externí odkaz:
https://doaj.org/article/3c07e32b8cbb4c9bbf1ce3db9c93dc16
Autor:
Philip Jalink, Massimiliano Caiazzo
Publikováno v:
Biology, Vol 10, Iss 8, p 740 (2021)
Neurological disorders are among the leading causes of death worldwide, accounting for almost all onsets of dementia in the elderly, and are known to negatively affect motor ability, mental and cognitive performance, as well as overall wellbeing and
Externí odkaz:
https://doaj.org/article/8bfe747f7e9e4b8eabd2d863e3cfdc64
Publikováno v:
Biology, Vol 10, Iss 9, p 835 (2021)
Liver organoids are stem cell-derived 3D structures that are generated by liver differentiation signals in the presence of a supporting extracellular matrix. Liver organoids overcome low complexity grade of bidimensional culture and high costs of in
Externí odkaz:
https://doaj.org/article/2e67840bb1d343fca9ff19556ab2222e
Autor:
Emilia Pascale, Giuseppina Divisato, Renata Palladino, Margherita Auriemma, Edward Faustine Ngalya, Massimiliano Caiazzo
Publikováno v:
Biomolecules, Vol 10, Iss 9, p 1269 (2020)
Midbrain dopamine neurons have crucial functions in motor and emotional control and their degeneration leads to several neurological dysfunctions such as Parkinson’s disease, addiction, depression, schizophrenia, and others. Despite advances in the
Externí odkaz:
https://doaj.org/article/d89aa34e72444d4b89430b883afb4e2c