Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Massimiliano Bissa"'
Autor:
Mohammad Arif Rahman, Massimiliano Bissa, Hanna Scinto, Savannah E. Howe, Sarkis Sarkis, Zhong-Min Ma, Anna Gutowska, Xunqing Jiang, Christina C. Luo, Luca Schifanella, Ramona Moles, Isabela Silva de Castro, Shraddha Basu, Kombo F. N’guessan, LaTonya D. Williams, Manuel Becerra-Flores, Melvin N. Doster, Tanya Hoang, Hyoyoung Choo-Wosoba, Emmanuel Woode, Yongjun Sui, Georgia D. Tomaras, Dominic Paquin-Proulx, Mangala Rao, James D. Talton, Xiang-Peng Kong, Susan Zolla-Pazner, Timothy Cardozo, Genoveffa Franchini, Jay A. Berzofsky
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Systemic vaccination of macaques with V1-deleted (ΔV1) envelope immunogens reduce the risk of SIVmac251 acquisition by approximately 60%, with protective roles played by V2-specific ADCC and envelope-specific mucosal IL-17+NKp44+ innate lym
Externí odkaz:
https://doaj.org/article/c46022c8eff943a69e28ba2d4818429f
Autor:
Mohammad Arif Rahman, Isabela Silva de Castro, Luca Schifanella, Massimiliano Bissa, Genoveffa Franchini
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
SIV and HIV-based envelope V1-deleted (ΔV1) vaccines, delivered systemically by the DNA/ALVAC/gp120 platform, decrease the risk of mucosal SIV or SHIV acquisition more effectively than V1-replete vaccines. Here we investigated the induction of mucos
Externí odkaz:
https://doaj.org/article/5e6a82b3d6df4b6a8438171f1e32dd9d
Autor:
Anna Gutowska, Sarkis Sarkis, Mohammad Arif Rahman, Katherine C. Goldfarbmuren, Ramona Moles, Massimiliano Bissa, Melvin Doster, Robyn Washington-Parks, Katherine McKinnon, Isabela Silva de Castro, Luca Schifanella, Genoveffa Franchini, Cynthia A. Pise-Masison
Publikováno v:
Pathogens, Vol 13, Iss 4, p 292 (2024)
The transient depletion of monocytes alone prior to exposure of macaques to HTLV-1 enhances both HTLV-1WT (wild type) and HTLV-1p12KO (Orf-1 knockout) infectivity, but seroconversion to either virus is not sustained over time, suggesting a progressiv
Externí odkaz:
https://doaj.org/article/244978497a084b2aa6b766b25236667b
Autor:
Massimiliano Bissa, Sohyoung Kim, Veronica Galli, Slim Fourati, Sarkis Sarkis, Anush Arakelyan, Isabela Silva de Castro, Mohammad Arif Rahman, Saori Fujiwara, Monica Vaccari, Jeffrey A. Tomalka, James D. Stamos, Luca Schifanella, Giacomo Gorini, Ramona Moles, Anna Gutowska, Guido Ferrari, Alexei Lobanov, David C. Montefiori, George W. Nelson, Margaret C. Cam, Marita Chakhtoura, Elias K. Haddad, Melvin N. Doster, Katherine McKinnon, Sophia Brown, David J. Venzon, Hyoyoung Choo-Wosoba, Matthew W. Breed, Kristin E. Killoran, Joshua Kramer, Leonid Margolis, Rafick P. Sekaly, Gordon L. Hager, Genoveffa Franchini
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
HIV vaccine development can be aided by knowledge of correlates of protection. Here the authors identify engagement and reprogramming of tolerogenic CD14+ myeloid cells mediating a spatiotemporal balance of pro- and anti-inflammatory responses, as co
Externí odkaz:
https://doaj.org/article/f273918f9336463f8dcd9cedb0b73046
Autor:
Mohammad Arif Rahman, Manuel Becerra-Flores, Yury Patskovsky, Isabela Silva de Castro, Massimiliano Bissa, Shraddha Basu, Xiaoying Shen, LaTonya D. Williams, Sarkis Sarkis, Kombo F. N’guessan, Celia LaBranche, Georgia D. Tomaras, Pyone Pyone Aye, Ronald Veazey, Dominic Paquin-Proulx, Mangala Rao, Genoveffa Franchini, Timothy Cardozo
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionAn efficacious HIV vaccine will need to elicit a complex package of innate, humoral, and cellular immune responses. This complex package of responses to vaccine candidates has been studied and yielded important results, yet it has been a
Externí odkaz:
https://doaj.org/article/f271626acd674386b239c0823d800dfb
Autor:
Massimiliano Bissa, Veronica Galli, Luca Schifanella, Monica Vaccari, Mohammad Arif Rahman, Giacomo Gorini, Nicolò Binello, Sarkis Sarkis, Anna Gutowska, Isabela Silva de Castro, Melvin N. Doster, Ramona Moles, Guido Ferrari, Xiaoying Shen, Georgia D. Tomaras, David C. Montefiori, Kombo F. N’guessan, Dominic Paquin-Proulx, Pamela A. Kozlowski, David J. Venzon, Hyoyoung Choo-Wosoba, Matthew W. Breed, Joshua Kramer, Genoveffa Franchini
Publikováno v:
Vaccines, Vol 11, Iss 11, p 1662 (2023)
At the heart of the DNA/ALVAC/gp120/alum vaccine’s efficacy in the absence of neutralizing antibodies is a delicate balance of pro- and anti-inflammatory immune responses that effectively decreases the risk of SIVmac251 acquisition in macaques. Vac
Externí odkaz:
https://doaj.org/article/c79e712a0eef406bace853be5af64634
Autor:
Anna Gutowska, Katherine McKinnon, Sarkis Sarkis, Melvin N. Doster, Massimiliano Bissa, Ramona Moles, James D. Stamos, Mohammad Arif Rahman, Robyn Washington-Parks, David Davis, Robert Yarchoan, Genoveffa Franchini, Cynthia A. Pise-Masison
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Human T cell leukemia virus type 1 (HTLV-1) persists in the host despite a vigorous immune response that includes cytotoxic T cells (CTL) and natural killer (NK) cells, suggesting the virus has developed effective mechanisms to counteract host immune
Externí odkaz:
https://doaj.org/article/71d7e6b3d5f24250b9a47b2a88566aca
Autor:
Ramona Moles, Sarkis Sarkis, Veronica Galli, Maria Omsland, Maria Artesi, Massimiliano Bissa, Katherine McKinnon, Sophia Brown, Vincent Hahaut, Robyn Washington-Parks, Joshua Welsh, David J Venzon, Anna Gutowska, Melvin N Doster, Matthew W Breed, Kristin E Killoran, Joshua Kramer, Jennifer Jones, Marcin Moniuszko, Anne Van den Broeke, Cynthia A Pise-Masison, Genoveffa Franchini
Publikováno v:
PLoS Pathogens, Vol 18, Iss 4, p e1010416 (2022)
We investigated the impact of monocytes, NK cells, and CD8+ T-cells in primary HTLV-1 infection by depleting cell subsets and exposing macaques to either HTLV-1 wild type (HTLV-1WT) or to the HTLV-1p12KO mutant unable to infect replete animals due to
Externí odkaz:
https://doaj.org/article/615eebba068a408f8b018f2bc095086a
Autor:
Isabela Silva de Castro, Giacomo Gorini, Rosemarie Mason, Jason Gorman, Massimiliano Bissa, Mohammad A. Rahman, Anush Arakelyan, Irene Kalisz, Stephen Whitney, Manuel Becerra-Flores, Eric Ni, Kristina Peachman, Hung V. Trinh, Michael Read, Mei-Hue Liu, Donald Van Ryk, Dominic Paquin-Proulx, Zhanna Shubin, Marina Tuyishime, Jennifer Peele, Mohammed S. Ahmadi, Raffaello Verardi, Juliane Hill, Margaret Beddall, Richard Nguyen, James D. Stamos, Dai Fujikawa, Susie Min, Luca Schifanella, Monica Vaccari, Veronica Galli, Melvin N. Doster, Namal P.M. Liyanage, Sarkis Sarkis, Francesca Caccuri, Celia LaBranche, David C. Montefiori, Georgia D. Tomaras, Xiaoying Shen, Margherita Rosati, Barbara K. Felber, George N. Pavlakis, David J. Venzon, William Magnanelli, Matthew Breed, Josh Kramer, Brandon F. Keele, Michael A. Eller, Claudia Cicala, James Arthos, Guido Ferrari, Leonid Margolis, Marjorie Robert-Guroff, Peter D. Kwong, Mario Roederer, Mangala Rao, Timothy J. Cardozo, Genoveffa Franchini
Publikováno v:
iScience, Vol 24, Iss 2, Pp 102047- (2021)
Summary: The efficacy of ALVAC-based HIV and SIV vaccines in humans and macaques correlates with antibodies to envelope variable region 2 (V2). We show here that vaccine-induced antibodies to SIV variable region 1 (V1) inhibit anti-V2 antibody-mediat
Externí odkaz:
https://doaj.org/article/0f4c13b40f5b4bb9bf78e5a35a226d78
Autor:
Luca Schifanella, Susan W Barnett, Massimiliano Bissa, Veronica Galli, Melvin N Doster, Monica Vaccari, Georgia D Tomaras, Xiaoying Shen, Sanjay Phogat, Ranajit Pal, David C Montefiori, Celia C LaBranche, Mangala Rao, Hung V Trinh, Robyn Washington-Parks, Namal P M Liyanage, Giacomo Gorini, Dallas R Brown, Frank Liang, Karin Loré, David J Venzon, William Magnanelli, Michelle Metrinko, Josh Kramer, Matthew Breed, Galit Alter, Ruth M Ruprecht, Genoveffa Franchini
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008531 (2020)
[This corrects the article DOI: 10.1371/journal.ppat.1008121.].
Externí odkaz:
https://doaj.org/article/de89ef036b2d42059a0aaccaf8620aca