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Development of adaptive anoikis resistance promotes metastasis that can be overcome by CDK8/19 Mediator kinase inhibition.

Autor: Monavarian M; Division of Molecular Cellular Pathology, Department of Pathology, O'Neal Comprehensive Cancer Center, University of Alabama, Heersink School of Medicine, Birmingham, AL, USA., Page EF; Division of Molecular Cellular Pathology, Department of Pathology, O'Neal Comprehensive Cancer Center, University of Alabama, Heersink School of Medicine, Birmingham, AL, USA., Rajkarnikar R; Division of Molecular Cellular Pathology, Department of Pathology, O'Neal Comprehensive Cancer Center, University of Alabama, Heersink School of Medicine, Birmingham, AL, USA., Kumari A; Division of Molecular Cellular Pathology, Department of Pathology, O'Neal Comprehensive Cancer Center, University of Alabama, Heersink School of Medicine, Birmingham, AL, USA., Macias LQ; Division of Molecular Cellular Pathology, Department of Pathology, O'Neal Comprehensive Cancer Center, University of Alabama, Heersink School of Medicine, Birmingham, AL, USA., Massicano F; UAB Biological Data Science Core, The University of Alabama at Birmingham, Birmingham, Alabama, USA., Lee NY; Division of Pharmacology, Chemistry and Biochemistry, College of Medicine, University of Arizona, Tucson, AZ, 85721, USA., Sahoo S; Department of Bioengineering, Indian Institute of Science, Bangalore, 560012, India., Hempel N; Department of Medicine, Division of Hematology Oncology, University of Pittsburgh School of Medicine Pittsburgh PA 15213., Jolly MK; Department of Bioengineering, Indian Institute of Science, Bangalore, 560012, India., Ianov L; UAB Biological Data Science Core, The University of Alabama at Birmingham, Birmingham, Alabama, USA.; Department of Neurobiology, The University of Alabama at Birmingham, Birmingham, Alabama, USA., Worthey E; UAB Biological Data Science Core, The University of Alabama at Birmingham, Birmingham, Alabama, USA., Singh A; Department of Electrical and Computer Engineering, University of Delaware, Newark, DE 19716, USA., Broude EV; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA., Mythreye K; Division of Molecular Cellular Pathology, Department of Pathology, O'Neal Comprehensive Cancer Center, University of Alabama, Heersink School of Medicine, Birmingham, AL, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Dec 06. Date of Electronic Publication: 2023 Dec 06.