Learning high-order interactions for polygenic risk prediction.

Autor: Massi MC; MOX, Department of Mathematics, Politecnico di Milano, Milan, Italy.; HDSC - Health Data Science Centre, Human Technopole, Milan, Italy., Franco NR; MOX, Department of Mathematics, Politecnico di Milano, Milan, Italy., Manzoni A; MOX, Department of Mathematics, Politecnico di Milano, Milan, Italy., Paganoni AM; MOX, Department of Mathematics, Politecnico di Milano, Milan, Italy., Park HA; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Medical Faculty, University of Heidelberg, Heidelberg, Germany., Hoffmeister M; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Brenner H; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Division of Preventive Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Chang-Claude J; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Cancer Epidemiology Group, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Ieva F; MOX, Department of Mathematics, Politecnico di Milano, Milan, Italy.; HDSC - Health Data Science Centre, Human Technopole, Milan, Italy., Zunino P; MOX, Department of Mathematics, Politecnico di Milano, Milan, Italy.

Publikováno v: PloS one [PLoS One] 2023 Feb 10; Vol. 18 (2), pp. e0281618. Date of Electronic Publication: 2023 Feb 10 (Print Publication: 2023).

Development of a method for generating SNP interaction-aware polygenic risk scores for radiotherapy toxicity.

Autor: Franco NR; MOX, Department of Mathematics, Politecnico di Milano, Italy. Electronic address: nicolarares.franco@polimi.it., Massi MC; MOX, Department of Mathematics, Politecnico di Milano, Italy; CADS-Center for Analysis, Decisions and Society, Human Technopole, Milan, Italy. Electronic address: michelacarlotta.massi@polimi.it., Ieva F; MOX, Department of Mathematics, Politecnico di Milano, Italy; CADS-Center for Analysis, Decisions and Society, Human Technopole, Milan, Italy; CHRP-National Center for Healthcare Research and Pharmacoepidemiology, University of Milano-Bicocca, Milan, Italy. Electronic address: francesca.ieva@polimi.it., Manzoni A; MOX, Department of Mathematics, Politecnico di Milano, Italy. Electronic address: andrea1.manzoni@polimi.it., Paganoni AM; MOX, Department of Mathematics, Politecnico di Milano, Italy; CADS-Center for Analysis, Decisions and Society, Human Technopole, Milan, Italy; CHRP-National Center for Healthcare Research and Pharmacoepidemiology, University of Milano-Bicocca, Milan, Italy. Electronic address: anna.paganoni@polimi.it., Zunino P; MOX, Department of Mathematics, Politecnico di Milano, Italy. Electronic address: paolo.zunino@polimi.it., Veldeman L; Department of Human Structure and Repair, Ghent University, Belgium; Department of Radiation Oncology, Ghent University Hospital, Belgium. Electronic address: liv.veldeman@ugent.be., Ost P; Department of Human Structure and Repair, Ghent University, Belgium; Department of Radiation Oncology, Ghent University Hospital, Belgium. Electronic address: piet.ost@ugent.be., Fonteyne V; Department of Human Structure and Repair, Ghent University, Belgium; Department of Radiation Oncology, Ghent University Hospital, Belgium. Electronic address: valerie.fonteyne@uzgent.be., Talbot CJ; Leicester Cancer Research Centre, Department of Genetics and Genome Biology, University of Leicester, United Kingdom. Electronic address: cjt14@leicester.ac.uk., Rattay T; Leicester Cancer Research Centre, Department of Genetics and Genome Biology, University of Leicester, United Kingdom. Electronic address: tr104@leicester.ac.uk., Webb A; Leicester Cancer Research Centre, Department of Genetics and Genome Biology, University of Leicester, United Kingdom. Electronic address: ajw51@leicester.ac.uk., Johnson K; Leicester Cancer Research Centre, Department of Genetics and Genome Biology, University of Leicester, United Kingdom. Electronic address: kj91@leicester.ac.uk., Lambrecht M; Department of Radiation Oncology, University Hospitals Leuven, Belgium. Electronic address: maarten.lambrecht@uzleuven.be., Haustermans K; Department of Radiation Oncology, University Hospitals Leuven, Belgium. Electronic address: karin.haustermans@uzleuven.be., De Meerleer G; Department of Radiation Oncology, University Hospitals Leuven, Belgium. Electronic address: gert.demeerleer@uzleuven.be., de Ruysscher D; Maastricht University Medical Center, the Netherlands; Department of Radiation Oncology (Maastro), GROW Institute for Oncology and Developmental Biology, Maastricht, the Netherlands. Electronic address: dirk.deruysscher@maastro.nl., Vanneste B; Department of Radiation Oncology (Maastro), GROW Institute for Oncology and Developmental Biology, Maastricht, the Netherlands. Electronic address: ben.vanneste@maastro.nl., Van Limbergen E; Maastricht University Medical Center, the Netherlands; Department of Radiation Oncology (Maastro), GROW Institute for Oncology and Developmental Biology, Maastricht, the Netherlands. Electronic address: evert.vanlimbergen@maastro.nl., Choudhury A; Translational Radiobiology Group, Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Christie Hospital, UK. Electronic address: ananya.choudhury@nhs.net., Elliott RM; Translational Radiobiology Group, Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Christie Hospital, UK. Electronic address: rebecca.m.elliott@manchester.ac.uk., Sperk E; Department of Radiation Oncology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany. Electronic address: Elena.sperk@umm.de., Veldwijk MR; Department of Radiation Oncology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany. Electronic address: marlon.veldwijk@medma.uni-heidelberg.de., Herskind C; Department of Radiation Oncology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany. Electronic address: Carsten.herskind@medma.uni-heidelberg.de., Avuzzi B; Department of Radiation Oncology 1, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. Electronic address: barbara.avuzzi@istitutotumori.mi.it., Noris Chiorda B; Department of Radiation Oncology 1, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. Electronic address: Barbara.Noris@istitutotumori.mi.it., Valdagni R; Department of Radiation Oncology 1, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; Department of Oncology and Haemato-Oncology, Università degli Studi di Milano, Milan, Italy; Prostate Cancer Program, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. Electronic address: riccardo.valdagni@istitutotumori.mi.it., Azria D; Department of Radiation Oncology, University Federation of Radiation Oncology, Montpellier Cancer Institute, Univ Montpellier MUSE, France. Electronic address: David.Azria@icm.unicancer.fr., Farcy-Jacquet MP; Department of Radiation Oncology, University Federation of Radiation Oncology, Institut de Cancérologie du Gard, Nimes, France. Electronic address: marie.pierre.farcy.jacquet@chu-nimes.fr., Brengues M; Department of Radiation Oncology, University Federation of Radiation Oncology, Montpellier Cancer Institute, Univ Montpellier MUSE, France. Electronic address: muriel.brengues@icm.unicancer.fr., Rosenstein BS; Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, USA. Electronic address: Barry.Rosenstein@mssm.edu., Stock RG; Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, USA. Electronic address: richard.stock@mssm.edu., Vega A; Grupo de Medicina Xenómica (USC), Fundación Pública Galega de Medicina Xenómica, Santiago de Compostela, Spain; Instituto de Investigación Sanitaria de Santiago de Compostela, Spain; Biomedical Network on Rare Diseases (CIBERER), Spain. Electronic address: ana.vega@usc.es., Aguado-Barrera ME; Grupo de Medicina Xenómica (USC), Fundación Pública Galega de Medicina Xenómica, Santiago de Compostela, Spain; Instituto de Investigación Sanitaria de Santiago de Compostela, Spain. Electronic address: miguelelias.aguado@usc.es., Sosa-Fajardo P; Grupo de Medicina Xenómica (USC), Fundación Pública Galega de Medicina Xenómica, Santiago de Compostela, Spain; Instituto de Investigación Sanitaria de Santiago de Compostela, Spain; Department of Radiation Oncology, Complexo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain. Electronic address: paloma.sosa.fajardo@sergas.es., Dunning AM; Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Labs, UK. Electronic address: amd24@medschl.cam.ac.uk., Fachal L; Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Labs, UK; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK. Electronic address: lf370@medschl.cam.ac.uk., Kerns SL; Departments of Radiation Oncology and Surgery, University of Rochester Medical Center, Rochester, USA. Electronic address: Sarah_Kerns@URMC.Rochester.edu., Payne D; Centre for Integrated Genomic Medical Research (CIGMR), University of Manchester, UK. Electronic address: Debbie.Payne@manchester.ac.uk., Chang-Claude J; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Germany. Electronic address: j.chang-claude@dkfz-heidelberg.de., Seibold P; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: p.seibold@Dkfz-Heidelberg.de., West CML; Translational Radiobiology Group, Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Christie Hospital, UK. Electronic address: Catharine.West@manchester.ac.uk., Rancati T; Prostate Cancer Program, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. Electronic address: Tiziana.rancati@istitutotumori.mi.it.

Publikováno v: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology [Radiother Oncol] 2021 Jun; Vol. 159, pp. 241-248. Date of Electronic Publication: 2021 Apr 08.

Data mining application to healthcare fraud detection: a two-step unsupervised clustering method for outlier detection with administrative databases.

Autor: Massi MC; MOX Laboratory, Department of Mathematics, Politecnico di Milano, Via Bonardi 9, Milan, Italy. michelacarlotta.massi@polimi.it.; CADS - Center for Analysis, Decisions and Society, Human Technopole, Palazzo Italia, Via Cristina Belgioioso 28, Milan, 20157, Italy. michelacarlotta.massi@polimi.it., Ieva F; MOX Laboratory, Department of Mathematics, Politecnico di Milano, Via Bonardi 9, Milan, Italy.; CADS - Center for Analysis, Decisions and Society, Human Technopole, Palazzo Italia, Via Cristina Belgioioso 28, Milan, 20157, Italy.; CHRP-National Center for Healthcare Research and Pharmacoepidemiology, Università degli Studi di Milano-Bicocca, via Bicocca degli Arcimboldi 8, Milan, 20126, Italy., Lettieri E; Department of Management Engineering, Politecnico di Milano, Via Lambruschini 4/c, Milan, 20100, Italy.

Publikováno v: BMC medical informatics and decision making [BMC Med Inform Decis Mak] 2020 Jul 14; Vol. 20 (1), pp. 160. Date of Electronic Publication: 2020 Jul 14.