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The GPCR adaptor protein Norbin regulates S1PR1 trafficking and the morphology, cell cycle and survival of PC12 cells.

Autor: Johansen VBI; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK.; Department of Biology, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hampson E; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK.; Vernalis (R&D) Ltd., Cambridge, UK., Tsonou E; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK.; Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Pantarelli C; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK., Chu JY; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK., Crossland L; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK., Okkenhaug H; Imaging Facility, The Babraham Institute, Cambridge, UK., Massey AJ; Vernalis (R&D) Ltd., Cambridge, UK., Hornigold DC; Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Welch HCE; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK. heidi.welch@babraham.ac.uk., Chetwynd SA; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK. stephen.chetwynd@babraham.ac.uk.

Publikováno v: Scientific reports [Sci Rep] 2023 Oct 25; Vol. 13 (1), pp. 18237. Date of Electronic Publication: 2023 Oct 25.

Targeting DYRK1A/B kinases to modulate p21-cyclin D1-p27 signalling and induce anti-tumour activity in a model of human glioblastoma.

Autor: Massey AJ; Vernalis (R&D) Ltd, Cambridge, UK., Benwell K; Vernalis (R&D) Ltd, Cambridge, UK., Burbridge M; Institut de Recherches Servier, Croissy-sur-Seine, France., Kotschy A; Servier Research Institute of Medicinal Chemistry, Budapest, Hungary., Walmsley DL; Vernalis (R&D) Ltd, Cambridge, UK.

Publikováno v: Journal of cellular and molecular medicine [J Cell Mol Med] 2021 Nov; Vol. 25 (22), pp. 10650-10662. Date of Electronic Publication: 2021 Oct 28.

Fragment-Derived Selective Inhibitors of Dual-Specificity Kinases DYRK1A and DYRK1B.

Autor: Lee Walmsley D; Vernalis (R&D) Ltd., Granta Park, Cambridge CB21 6GB, U.K., Murray JB; Vernalis (R&D) Ltd., Granta Park, Cambridge CB21 6GB, U.K., Dokurno P; Vernalis (R&D) Ltd., Granta Park, Cambridge CB21 6GB, U.K., Massey AJ; Vernalis (R&D) Ltd., Granta Park, Cambridge CB21 6GB, U.K., Benwell K; Vernalis (R&D) Ltd., Granta Park, Cambridge CB21 6GB, U.K., Fiumana A; Vernalis (R&D) Ltd., Granta Park, Cambridge CB21 6GB, U.K., Foloppe N; Vernalis (R&D) Ltd., Granta Park, Cambridge CB21 6GB, U.K., Ray S; Vernalis (R&D) Ltd., Granta Park, Cambridge CB21 6GB, U.K., Smith J; Vernalis (R&D) Ltd., Granta Park, Cambridge CB21 6GB, U.K., Surgenor AE; Vernalis (R&D) Ltd., Granta Park, Cambridge CB21 6GB, U.K., Edmonds T; Institut de Recherches Servier, 125 Chemin de Ronde, Croissy-sur-Seine 78290, France., Demarles D; Technologie Servier, 27 Rue Eugène Vignat, Orleans 45000, France., Burbridge M; Institut de Recherches Servier, 125 Chemin de Ronde, Croissy-sur-Seine 78290, France., Cruzalegui F; Institut de Recherches Servier, 125 Chemin de Ronde, Croissy-sur-Seine 78290, France., Kotschy A; Servier Research Institute of Medicinal Chemistry, Záhony u. 7., Budapest H-1031, Hungary., Hubbard RE; Vernalis (R&D) Ltd., Granta Park, Cambridge CB21 6GB, U.K.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2021 Jul 08; Vol. 64 (13), pp. 8971-8991. Date of Electronic Publication: 2021 Jun 18.

Structure-Guided Discovery of Potent and Selective DYRK1A Inhibitors.

Autor: Weber C; Servier Research Institute of Medicinal Chemistry, Záhony u. 7., H-1031 Budapest, Hungary., Sipos M; Servier Research Institute of Medicinal Chemistry, Záhony u. 7., H-1031 Budapest, Hungary., Paczal A; Servier Research Institute of Medicinal Chemistry, Záhony u. 7., H-1031 Budapest, Hungary., Balint B; Servier Research Institute of Medicinal Chemistry, Záhony u. 7., H-1031 Budapest, Hungary., Kun V; Servier Research Institute of Medicinal Chemistry, Záhony u. 7., H-1031 Budapest, Hungary., Foloppe N; Vernalis (R&D) Ltd., Granta Park, CB21 6GB Cambridge, U.K., Dokurno P; Vernalis (R&D) Ltd., Granta Park, CB21 6GB Cambridge, U.K., Massey AJ; Vernalis (R&D) Ltd., Granta Park, CB21 6GB Cambridge, U.K., Walmsley DL; Vernalis (R&D) Ltd., Granta Park, CB21 6GB Cambridge, U.K., Hubbard RE; Vernalis (R&D) Ltd., Granta Park, CB21 6GB Cambridge, U.K., Murray J; Vernalis (R&D) Ltd., Granta Park, CB21 6GB Cambridge, U.K., Benwell K; Vernalis (R&D) Ltd., Granta Park, CB21 6GB Cambridge, U.K., Edmonds T; Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy-sur-Seine, France., Demarles D; Technologie Servier, 27 Rue Eugène Vignat, 45000 Orleans, France., Bruno A; Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy-sur-Seine, France., Burbridge M; Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy-sur-Seine, France., Cruzalegui F; Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy-sur-Seine, France., Kotschy A; Servier Research Institute of Medicinal Chemistry, Záhony u. 7., H-1031 Budapest, Hungary.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2021 May 27; Vol. 64 (10), pp. 6745-6764. Date of Electronic Publication: 2021 May 12.