Zobrazeno 1 - 10
of 240
pro vyhledávání: '"Masoud Jamei"'
Publikováno v:
Antibiotics, Vol 13, Iss 9, p 862 (2024)
The impact of physiological changes during aging on drug disposition has not always been thoroughly assessed in clinical studies. This has left an open question such as how and to what extent patho- and physiological changes in renal function can aff
Externí odkaz:
https://doaj.org/article/b3aba943c5d948cab4c675bbf473c256
Autor:
Felix Stader, Cong Liu, Abdallah Derbalah, Hiroshi Momiji, Xian Pan, Iain Gardner, Masoud Jamei, Armin Sepp
Publikováno v:
Antibodies, Vol 13, Iss 3, p 70 (2024)
The bioavailability of a monoclonal antibody (mAb) or another therapeutic protein after subcutaneous (SC) dosing is challenging to predict from first principles, even if the impact of injection site physiology and drug properties on mAb bioavailabili
Externí odkaz:
https://doaj.org/article/0318d20ff39a45c19a6b62c7a4b24ef2
Publikováno v:
Pharmaceutics, Vol 16, Iss 4, p 474 (2024)
Physiological changes during pregnancy can alter maternal and fetal drug exposure. The objective of this work was to predict maternal and umbilical ceftazidime pharmacokinetics during pregnancy. Ceftazidime transplacental permeability was predicted f
Externí odkaz:
https://doaj.org/article/8d8d98be48f3464a994c3964ffc070c2
Autor:
Nikunjkumar Patel, James F. Clarke, Farzaneh Salem, Tariq Abdulla, Frederico Martins, Sumit Arora, Eleftheria Tsakalozou, Arran Hodgkinson, Omid Arjmandi‐Tash, Sinziana Cristea, Priyanka Ghosh, Khondoker Alam, Sam G. Raney, Masoud Jamei, Sebastian Polak
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 8, Pp 1060-1084 (2022)
Abstract Physiologically‐based pharmacokinetic models combine knowledge about physiology, drug product properties, such as physicochemical parameters, absorption, distribution, metabolism, excretion characteristics, formulation attributes, and tria
Externí odkaz:
https://doaj.org/article/afd2ab177bf7434a8488d0d0e8d82e93
Autor:
Janak R. Wedagedera, Anthonia Afuape, Siri Kalyan Chirumamilla, Hiroshi Momiji, Robert Leary, Mike Dunlavey, Richard Matthews, Khaled Abduljalil, Masoud Jamei, Frederic Y. Bois
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 6, Pp 755-765 (2022)
Abstract Physiologically‐based pharmacokinetic (PBPK) models usually include a large number of parameters whose values are obtained using in vitro to in vivo extrapolation. However, such extrapolations can be uncertain and may benefit from inclusio
Externí odkaz:
https://doaj.org/article/b22a6cafc47a40658b0d29adf692a9fc
Autor:
Helen Humphries, Lisa Almond, Alexander Berg, Iain Gardner, Oliver Hatley, Xian Pan, Ben Small, Mian Zhang, Masoud Jamei, Klaus Romero
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 11, Pp 1382-1395 (2021)
Abstract Tuberculosis (TB) remains a global health problem and there is an ongoing effort to develop more effective therapies and new combination regimes that can reduce duration of treatment. The purpose of this study was to demonstrate utility of a
Externí odkaz:
https://doaj.org/article/1f55df4e4fa5444cbd1301d827c62ac4
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 8, Pp 878-889 (2021)
Abstract There is a risk of exposure to drugs in neonates during the lactation period due to maternal drug intake. The ability to predict drugs of potential hazards to the neonates would be useful in a clinical setting. This work aimed to evaluate th
Externí odkaz:
https://doaj.org/article/0450be931f7f408c8d969165a977cbb7
Publikováno v:
Frontiers in Pediatrics, Vol 10 (2022)
Perinatal pharmacology is influenced by a myriad of physiological variables that are changing dynamically. The influence of these covariates has not been assessed systemically. The objective of this work was to use theophylline as a model drug and to
Externí odkaz:
https://doaj.org/article/4d4824f1cb9842fdb56b920570cf5977
Publikováno v:
Pharmaceutics, Vol 13, Iss 8, p 1169 (2021)
Acid reducing agents (ARAs) reduce the dissolution rate of weakly basic drugs in the stomach potentially leading to lower bioavailability. Formulating the API as a rapidly dissolving salt is one strategy employed to reduce the impact of ARAs on disso
Externí odkaz:
https://doaj.org/article/31f5d7c1c0e64c6d830ac435beef09f3
Autor:
Iain Gardner, Mandy Xu, Chunyan Han, Yi Wang, Xingjin Jiao, Masoud Jamei, Hiba Khalidi, Peter Kilford, Sibylle Neuhoff, Roz Southall, David B. Turner, Helen Musther, Barry Jones, Simon Taylor
Publikováno v:
Xenobiotica. 52:943-956
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10c6754c09a98fa6107a6916ee8db650
https://doi.org/10.1080/00498254.2022.2132426
https://doi.org/10.1080/00498254.2022.2132426