C5 Inhibitor Avacincaptad Pegol for Geographic Atrophy Due to Age-Related Macular Degeneration: A Randomized Pivotal Phase 2/3 Trial.

Autor: Jaffe GJ; Department of Ophthalmology, Duke University, Durham, North Carolina., Westby K; IVERIC bio, Inc., New York, New York., Csaky KG; Retina Foundation of Southwest, Dallas, Texas., Monés J; Institut de la Màcula and Barcelona Macula Foundation, Barcelona, Spain., Pearlman JA; Vitreoretinal Medical Group, Inc., Sacramento, California., Patel SS; West Texas Retina Consultants, Abilene, Texas., Joondeph BC; Colorado Retina, Denver, Colorado., Randolph J; Center for Retina and Macular Disease, Winter Haven, Florida., Masonson H; IVERIC bio, Inc., New York, New York., Rezaei KA; IVERIC bio, Inc., New York, New York. Electronic address: karezaei@yahoo.com.

Publikováno v: Ophthalmology [Ophthalmology] 2021 Apr; Vol. 128 (4), pp. 576-586. Date of Electronic Publication: 2020 Sep 01.

Bilateral visual improvement with unilateral gene therapy injection for Leber hereditary optic neuropathy.

Autor: Yu-Wai-Man P; Cambridge Centre for Brain Repair and MRC Mitochondrial Biology Unit, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, UK. sahelja@upmc.edu py237@cam.ac.uk.; Cambridge Eye Unit, Addenbrooke's Hospital, Cambridge University Hospitals, Cambridge CB2 0QQ, UK.; Moorfields Eye Hospital, London EC1V 2PD, UK.; UCL Institute of Ophthalmology, University College London, London EC1V 9EL, UK., Newman NJ; Departments of Ophthalmology, Neurology and Neurological Surgery, Emory University School of Medicine, Atlanta, GA 30322, USA., Carelli V; IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Clinica Neurologica, 40139 Bologna, Italy.; Unit of Neurology, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, 40139 Bologna, Italy., Moster ML; Departments of Neurology and Ophthalmology, Wills Eye Hospital and Thomas Jefferson University, Philadelphia, PA 19107, USA., Biousse V; Departments of Ophthalmology, Neurology and Neurological Surgery, Emory University School of Medicine, Atlanta, GA 30322, USA., Sadun AA; Doheny Eye Institute and UCLA School of Medicine, Los Angeles, CA 90086, USA., Klopstock T; Friedrich Baur Institute at the Department of Neurology, University Hospital, LMU Munich, 80336 Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), 80336 Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), 80336 Munich, Germany., Vignal-Clermont C; Department of Neuro-Ophthalmology and Emergencies, Rothschild Foundation Hospital, 75019 Paris, France.; Centre Hospitalier National d'Ophtalmologie des Quinze Vingts, FOReSIGHT, INSERM-DGOS CIC 1423, 75012 Paris, France., Sergott RC; Departments of Neurology and Ophthalmology, Wills Eye Hospital and Thomas Jefferson University, Philadelphia, PA 19107, USA., Rudolph G; Department of Ophthalmology, University Hospital, LMU Munich, 80336 Munich, Germany., La Morgia C; IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Clinica Neurologica, 40139 Bologna, Italy.; Unit of Neurology, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, 40139 Bologna, Italy., Karanjia R; Doheny Eye Institute and UCLA School of Medicine, Los Angeles, CA 90086, USA.; Ottawa Hospital Research Institute and University of Ottawa Eye Institute, Ottawa, Ontario K1H 8L6, Canada., Taiel M; GenSight Biologics, 75012 Paris, France., Blouin L; GenSight Biologics, 75012 Paris, France., Burguière P; GenSight Biologics, 75012 Paris, France., Smits G; GenSight Biologics, New York, NY 10016, USA., Chevalier C; GenSight Biologics, 75012 Paris, France., Masonson H; GenSight Biologics, New York, NY 10016, USA., Salermo Y; GenSight Biologics, New York, NY 10016, USA., Katz B; GenSight Biologics, New York, NY 10016, USA., Picaud S; Sorbonne Université, INSERM, CNRS, Institut de la Vision, 75012 Paris, France., Calkins DJ; The Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Sahel JA; Centre Hospitalier National d'Ophtalmologie des Quinze Vingts, FOReSIGHT, INSERM-DGOS CIC 1423, 75012 Paris, France. sahelja@upmc.edu py237@cam.ac.uk.; Sorbonne Université, INSERM, CNRS, Institut de la Vision, 75012 Paris, France.; Fondation Ophtalmologique A. de Rothschild, 25-29 Rue Manin, 75019 Paris, France.; Department of Ophthalmology, The University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2020 Dec 09; Vol. 12 (573).

A phase 2/3, multicenter, randomized, double-masked, 2-year trial of pegaptanib sodium for the treatment of diabetic macular edema

Autor: Sultan, Mb, Zhou, D, Loftus, J, Dombi, T, Ice, Ks, Bird, A, D'Amico, D, Herson, J, Klein, R, Wallisch, M, de Gronckel, S, Danielson, L, Quinaz, E, Wang, K, Balbueno, S, Mikusova, B, Spiller, Hw, Cameron, P, Sawa, M, Wallace, S, Altaweel, M, Danis, R, Domalpally, A, Alexander, S, Corkery, E, Daywalt, M, Dohm, K, Endres, R, Goulding, A, Reimers, J, Susman, R, Wabers, H, Whilhelmson, T, White, J, Lim, L, Wong, T, Mitchell, P, Kralinger, M, Stur, M, Avila, M, Farah, M, Lavinsky, J, Maberly, D, Olivier, S, Rosemont, P, Dusova, J, Ernest, J, Fiser, I, Kolar, P, Rehak, J, Larsen, M, Berrod, Jp, Devin, F, Koenig Supiot, F, Massin, P, Soubrane, G, Dithmar, S, Holz, F, Joussen, A, Lappas, A, Bartz Schmidt KU, Spital, G, Wiedemann, P, Vergados, I, Azad, R, Jalali, S, Murthy, P, Nagpal, M, Bandello, F, Lanzetta, Paolo, Lattanzio, R, Menchini, U, Keunen, J, Figueira, J, Sarra, Gm, Trittibach, P, Brand, C, Talks, J, Carnevale, K, Ciulla, Ta, Connor, Tb, Elliott, D, Friberg, Tr, Garcia, Ca, Gonzalez, Vh, Gross, N, Halperin, Ls, Hudson HL 3rd, Kokame, G, Lit, E, Marcus, Dm, Patel, S, Pavan, P, Rosa, R, Sang, D, Singer, M, Varenhorst, Mp, Wells, J, Adamis, Ap, Betts, F, Burke, K, Cunningham ET Jr, Curtiss, K, Goldbaum, M, Guyer, Dr, Harrison, E, Katz, B, Liss, C, Masonson, H, O'Shaughnessy, D, Archer, R, Barbeito, R, Bojko, R, Borgstadt, M, Carlin, R, Chappell, P, Cobles, C, Culhane, J, Davisson, B, Elkins, M, Eveleth, D, Fernstrom, S, Franklin, K, Houghton, F, Edward Hume, H, Hilary Jones, J, Kirschner, K, Kwok, K, Lee, P, Littel, A, Lock, K, Lyster, S, Machado, P, Maeda Chubachi, T, Maute, A, Mulvaney, A, O'Neill, B, Paggiarino, D, Quinto Olegario, K, Pleil, A, Stewart, C, Wilson, G, Yan, E, Zurlo, M.

Publikováno v: Ophthalmology, 118, 6, pp. 1107-18
Ophthalmology, 118, 1107-18

Item does not contain fulltext PURPOSE: To confirm the safety and compare the efficacy of intravitreal pegaptanib sodium 0.3 mg versus sham injections in subjects with diabetic macular edema (DME) involving the center of the macula associated with vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca12d5e116c836fbe1935d6ad645a888
http://hdl.handle.net/11390/872145

Pegaptanib sodium for neovascular age-related macular degeneration: third-year safety results of the VEGF Inhibition Study in Ocular Neovascularisation (VISION) trial.

Autor: Singerman, L.J., Masonson, H., Patel, M., Adamis, A.P., Buggage, R., Cunningham, E., Goldbaum, M., Katz, B., Guyer, D.

Publikováno v: British Journal of Ophthalmology; Dec2008, Vol. 92 Issue 12, p1606-1611, 6p, 1 Diagram, 4 Charts, 1 Graph

Exploring Current Molecular Targets in the Treatment of Neovascular Age-Related Macular Degeneration toward the Perspective of Long-Term Agents.

Autor: Fragiotta, Serena^1,2 (AUTHOR) m.sepe@ausl.latina.it, Bassis, Lorena¹ (AUTHOR) lorena.bassis@uniroma1.it, Abdolrahimzadeh, Barmak³ (AUTHOR) barmak.zadeh@practiceplusgroup.com, Marino, Alessandra^1,4 (AUTHOR) alessandra.marino@uniroma1.it, Sepe, Massimiliano² (AUTHOR), Abdolrahimzadeh, Solmaz^1,4 (AUTHOR) solmaz.abdolrahimzadeh@uniroma1.it

Publikováno v: International Journal of Molecular Sciences. Apr2024, Vol. 25 Issue 8, p4433. 16p.