Výsledky vyhledávání - "Mason W. Freeman"

Akademický článek

An overview of the process, progress, and outcomes of a National Center for Accelerated Innovation: The Boston Biomedical Innovation Center Experience

Autor: Elliott M. Antman, Mason W. Freeman, David E. Golan, Roger Kitterman, Erin McKenna, John Parrish, Cheryl Vaughan, Lesley Watts, Joseph Loscalzo

Publikováno v: Journal of Clinical and Translational Science, Vol 5 (2021)

Implementation of clinically useful research discoveries in the academic environment is challenged by limited funding for early phase proof-of-concept studies and inadequate expertise in product development and commercialization. To address these lim

Externí odkaz: https://doaj.org/article/91ea09b4e2e1478f8d55a1ec3a05c254

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Akademický článek

Endogenous β-glucocerebrosidase activity in Abca12−/−epidermis elevates ceramide levels after topical lipid application but does not restore barrier function

Autor: Jorge F. Haller, Paul Cavallaro, Nicholas J. Hernandez, Lee Dolat, Stephanie J. Soscia, Ruth Welti, Gregory A. Grabowski, Michael L. Fitzgerald, Mason W. Freeman

Publikováno v: Journal of Lipid Research, Vol 55, Iss 3, Pp 493-503 (2014)

ABCA12 mutations disrupt the skin barrier and cause harlequin ichthyosis. We previously showed Abca12−/− skin has increased glucosylceramide (GlcCer) and correspondingly lower amounts of ceramide (Cer). To examine why loss of ABCA12 leads to accu

Externí odkaz: https://doaj.org/article/61096b968579476984c13ed742b53d1c

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Akademický článek

ABCA3 inactivation in mice causes respiratory failure, loss of pulmonary surfactant, and depletion of lung phosphatidylglycerols⃞

Autor: Michael L. Fitzgerald, Ramnik Xavier, Kathleen J. Haley, Ruth Welti, Julie L. Goss, Cari E. Brown, Debbie Z. Zhuang, Susan A. Bell, Naifang Lu, Mary Mckee, Brian Seed, Mason W. Freeman

Publikováno v: Journal of Lipid Research, Vol 48, Iss 3, Pp 621-632 (2007)

The highly branched mammalian lung relies on surfactant, a mixture of phospholipids, cholesterol, and hydrophobic proteins, to reduce intraalveolar surface tension and prevent lung collapse. Human mutations in the ABCA3 transporter have been associat

Externí odkaz: https://doaj.org/article/ff30baedb58c4507ad5fe288a371c737

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Akademický článek

Effects of overexpression of the amino-terminal fragment of apolipoprotein B on apolipoprotein B and lipoprotein production

Autor: Zhaohui Li, Yuko Kako, Ling Pang, Mason W. Freeman, Jane M. Glick, Xinzhong Wang, Ira J. Goldberg

Publikováno v: Journal of Lipid Research, Vol 41, Iss 12, Pp 1912-1920 (2000)

In vitro studies have shown that the binding site for microsomal triglyceride transfer protein (MTP) is within the first 17% of apoB (apoB-17). Expression of apoB-48 in McArdle cells decreases endogenous lipoprotein production; however, overexpressio

Externí odkaz: https://doaj.org/article/7f8a7352be17456aae4ebd06b57c7a04

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Akademický článek

Cellular cholesterol efflux in heterozygotes for Tangier disease is markedly reduced and correlates with high density lipoprotein cholesterol concentration and particle size

Autor: Margaret E. Brousseau, Gretchen P. Eberhart, Josée Dupuis, Bela F. Asztalos, Allison L. Goldkamp, Ernst J. Schaefer, Mason W. Freeman

Publikováno v: Journal of Lipid Research, Vol 41, Iss 7, Pp 1125-1135 (2000)

Tangier disease (TD), caused by mutations in the ATP-binding cassette 1 (ABC-1) gene, is a rare genetic disorder characterized by severe deficiency of high density lipoproteins (HDL) in the plasma, hypercatabolism of HDL, and defective apolipoprotein

Externí odkaz: https://doaj.org/article/953e0aab55ba427798c3141b7e7c1d65

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Akademický článek

Novel mutations in the gene encoding ATP-binding cassette 1 in four Tangier disease kindreds

Autor: Margaret E. Brousseau, Ernst J. Schaefer, Josee Dupuis, Brenda Eustace, Paul Van Eerdewegh, Allison L. Goldkamp, Lisa M. Thurston, Michael G. FitzGerald, Diane Yasek-McKenna, Gilmore O'Neill, Gretchen P. Eberhart, Barbara Weiffenbach, Jose M. Ordovas, Mason W. Freeman, Robert H. Brown, Jr., Jessie Z. Gu

Publikováno v: Journal of Lipid Research, Vol 41, Iss 3, Pp 433-441 (2000)

Abstract: Tangier disease (TD) is an autosomal co-dominant disorder in which homozygotes have a marked deficiency of high density lipoprotein (HDL) cholesterol and, in some cases, peripheral neuropathy and premature coronary heart disease (CHD). Homo

Externí odkaz: https://doaj.org/article/fd9cecdea07e49dd948151a1774c02e1

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A 96‐week, double‐blind, randomized controlled trial comparing bexagliflozin to glimepiride as an adjunct to metformin for the treatment of type 2 diabetes in adults

Autor: Yuan‐Di Halvorsen, John Paul Lock, Juan P. Frias, Francisco José Tinahones, Dominik Dahl, Annie L. Conery, Mason W. Freeman

Publikováno v: Diabetes, Obesity and Metabolism. 25:293-301

To compare the effects of bexagliflozin tablets 20 mg, with those of optimally titrated glimepiride when used to treat adults with type 2 diabetes mellitus (T2DM) inadequately controlled by metformin.Adults with type 2 diabetes (n = 426) taking metfo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d85a8b688c7306ced6b3a16cb6b189f2
https://doi.org/10.1111/dom.14875

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Phase 2 Trial of Baxdrostat for Treatment-Resistant Hypertension

Autor: Mason W. Freeman, Yuan-Di Halvorsen, William Marshall, Mackenzie Pater, Jon Isaacsohn, Catherine Pearce, Brian Murphy, Nicholas Alp, Ajay Srivastava, Deepak L. Bhatt, Morris J. Brown

Publikováno v: The New England journal of medicine.

Aldosterone synthase controls the synthesis of aldosterone and has been a pharmacologic target for the treatment of hypertension for several decades. Selective inhibition of aldosterone synthase is essential but difficult to achieve because cortisol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::315f663a857e452ddb2c719bfea189ae
https://pubmed.ncbi.nlm.nih.gov/36342143

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