Zobrazeno 1 - 10 of 118 pro vyhledávání: '"Mason W, Freeman"'
1
Akademický článek
An overview of the process, progress, and outcomes of a National Center for Accelerated Innovation: The Boston Biomedical Innovation Center Experience
Autor: Elliott M. Antman, Mason W. Freeman, David E. Golan, Roger Kitterman, Erin McKenna, John Parrish, Cheryl Vaughan, Lesley Watts, Joseph Loscalzo
Publikováno v: Journal of Clinical and Translational Science, Vol 5 (2021)
Implementation of clinically useful research discoveries in the academic environment is challenged by limited funding for early phase proof-of-concept studies and inadequate expertise in product development and commercialization. To address these lim
Externí odkaz: https://doaj.org/article/91ea09b4e2e1478f8d55a1ec3a05c254
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3
A 96‐week, double‐blind, randomized controlled trial comparing bexagliflozin to glimepiride as an adjunct to metformin for the treatment of type 2 diabetes in adults
Autor: Yuan‐Di Halvorsen, John Paul Lock, Juan P. Frias, Francisco José Tinahones, Dominik Dahl, Annie L. Conery, Mason W. Freeman
Publikováno v: Diabetes, Obesity and Metabolism. 25:293-301
To compare the effects of bexagliflozin tablets 20 mg, with those of optimally titrated glimepiride when used to treat adults with type 2 diabetes mellitus (T2DM) inadequately controlled by metformin.Adults with type 2 diabetes (n = 426) taking metfo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d85a8b688c7306ced6b3a16cb6b189f2
https://doi.org/10.1111/dom.14875
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4
Phase 2 Trial of Baxdrostat for Treatment-Resistant Hypertension
Autor: Mason W. Freeman, Yuan-Di Halvorsen, William Marshall, Mackenzie Pater, Jon Isaacsohn, Catherine Pearce, Brian Murphy, Nicholas Alp, Ajay Srivastava, Deepak L. Bhatt, Morris J. Brown
Publikováno v: The New England journal of medicine.
Aldosterone synthase controls the synthesis of aldosterone and has been a pharmacologic target for the treatment of hypertension for several decades. Selective inhibition of aldosterone synthase is essential but difficult to achieve because cortisol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::315f663a857e452ddb2c719bfea189ae
https://pubmed.ncbi.nlm.nih.gov/36342143
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7
Akademický článek
Endogenous β-glucocerebrosidase activity in Abca12−/−epidermis elevates ceramide levels after topical lipid application but does not restore barrier function
Autor: Jorge F. Haller, Paul Cavallaro, Nicholas J. Hernandez, Lee Dolat, Stephanie J. Soscia, Ruth Welti, Gregory A. Grabowski, Michael L. Fitzgerald, Mason W. Freeman
Publikováno v: Journal of Lipid Research, Vol 55, Iss 3, Pp 493-503 (2014)
ABCA12 mutations disrupt the skin barrier and cause harlequin ichthyosis. We previously showed Abca12−/− skin has increased glucosylceramide (GlcCer) and correspondingly lower amounts of ceramide (Cer). To examine why loss of ABCA12 leads to accu
Externí odkaz: https://doaj.org/article/61096b968579476984c13ed742b53d1c
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8
A 12‐week, randomized, double‐blind, placebo‐controlled, four‐arm dose‐finding phase 2 study evaluating bexagliflozin as monotherapy for adults with type 2 diabetes
Autor: Yuan-Di C. Halvorsen, Geoffrey A. Walford, Mason W. Freeman, Heidy Russell, Monica Massaro, Tara K. Thurber
Publikováno v: Diabetes, Obesity and Metabolism. 22:566-573
AIM To compare the safety and efficacy of bexagliflozin administered as monotherapy at three dosage strengths over a 12-week period to patients with type 2 diabetes who were either naive to pharmacotherapy or were previously prescribed one oral hypog
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aba63ac5602ba17e5256caca79fb152
https://doi.org/10.1111/dom.13928
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10
Akademický článek
ABCA3 inactivation in mice causes respiratory failure, loss of pulmonary surfactant, and depletion of lung phosphatidylglycerols⃞
Autor: Michael L. Fitzgerald, Ramnik Xavier, Kathleen J. Haley, Ruth Welti, Julie L. Goss, Cari E. Brown, Debbie Z. Zhuang, Susan A. Bell, Naifang Lu, Mary Mckee, Brian Seed, Mason W. Freeman
Publikováno v: Journal of Lipid Research, Vol 48, Iss 3, Pp 621-632 (2007)
The highly branched mammalian lung relies on surfactant, a mixture of phospholipids, cholesterol, and hydrophobic proteins, to reduce intraalveolar surface tension and prevent lung collapse. Human mutations in the ABCA3 transporter have been associat
Externí odkaz: https://doaj.org/article/ff30baedb58c4507ad5fe288a371c737
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