Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Mason R. McMullen"'
Autor:
Aissam Ikmi, Petrus J. Steenbergen, Marie Anzo, Mason R. McMullen, Anniek Stokkermans, Lacey R. Ellington, Matthew C. Gibson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
How the developmental capacity of long-lived animals copes with fluctuations in the food supply is unclear. Here, the authors show using the sea anemone Nematostella vectensis that the crosstalk between Target of Rapamycin and fibroblast growth facto
Externí odkaz:
https://doaj.org/article/00b046c80d7547cd82b8488c61f60168
Autor:
Marie Anzo, Anniek Stokkermans, Lacey R. Ellington, Aissam Ikmi, Petrus J. Steenbergen, Mason R. McMullen, Matthew C. Gibson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
In cnidarians, axial patterning is not restricted to embryogenesis but continues throughout a prolonged life history filled with unpredictable environmental changes. How this developmental capacity copes with fluctuations of food availability and whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb05e2d5e85d9867a98c0dc5bc395b4
http://link.springer.com/article/10.1038/s41467-020-18133-0
http://link.springer.com/article/10.1038/s41467-020-18133-0
Development of noviomimetics that modulate molecular chaperones and manifest neuroprotective effects
Autor:
Rick T. Dobrowsky, Zhenyuan You, Sean M. Emery, Mason R. McMullen, Mercy Anyika, Brian S. J. Blagg, Leah K. Forsberg
Publikováno v:
European Journal of Medicinal Chemistry. 143:1428-1435
Heat shock protein 90 (Hsp90) is a chaperone under investigation for the treatment of cancer and neurodegenerative diseases. Neuroprotective Hsp90 C-terminal inhibitors derived from novobiocin (novologues) include KU-32 and KU-596. These novologues m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e8c6a066b7abca6c68c3b2d628e5c8d
https://doi.org/10.1016/j.ejmech.2017.10.038
https://doi.org/10.1016/j.ejmech.2017.10.038
KU-32 and KU-596 are novobiocin-derived, C-terminal heat shock protein 90 (Hsp90) modulators that induce Hsp70 levels and manifest neuroprotective activity. However, the synthetically complex noviose sugar requires 10 steps to prepare, which makes tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f5baf65df1de4200ac63635ef22f7a5
https://europepmc.org/articles/PMC4716602/
https://europepmc.org/articles/PMC4716602/
