Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Mason Clive Philip"'
Autor:
Andrew J. Bibb, Petar I. Nikiforov, Stuart Field, Steven J. Fussell, Olivier Dirat, Mason Clive Philip, Alan John Pettman, Colin M. Burns, Green Stuart, Ian B. Moses, Jinu S. Mathew, Graham Checksfield, Barry Richard Dillon, Flavien Susanne, Suju Mathew
Publikováno v:
Organic Process Research & Development. 15:1010-1017
We report the discovery and optimization of an amine-promoted Friedel–Crafts alkylation of cinnamaldehyde with 4-hydroxymethyl phenol. This reaction has been used successfully on commercial scale (200 kg) in the context of the manufacture of fesote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac12c5d6e2599650d59bca0d61c550ab
https://doi.org/10.1021/op200107g
https://doi.org/10.1021/op200107g
Publikováno v:
Tetrahedron Letters. 40:2187-2190
A four step synthesis of a chiral glutarate half ester intermediate, required for the preparation of candoxatril, has been developed from t-butyl acrylate. The key steps in this route include a stereoselective synthesis of a trisubstituted alkene and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37c957235291012d17796cb31e658c10
https://doi.org/10.1016/s0040-4039(98)02687-2
https://doi.org/10.1016/s0040-4039(98)02687-2
Autor:
D. C. Waite and, Mason Clive Philip
Publikováno v:
Organic Process Research & Development. 2:116-120
A regioselective Heck cross-coupling strategy is presented for the large-scale preparation of the thromboxane receptor antagonist 3-{3-[2-(4-chlorobenzenesulfonamido)ethyl]-5-(4-fluorobenzyl)phenyl}propionic acid (1). Commercially available 3-bromo-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e878aab1c346137bc2428fbce152f58a
https://doi.org/10.1021/op970060y
https://doi.org/10.1021/op970060y