Výsledky vyhledávání - "Mason C Wilkinson"

Akademický článek

A single amino acid polymorphism in natural Metchnikowin alleles of Drosophila results in systemic immunity and life history tradeoffs.

Autor: Jessamyn I Perlmutter, Joanne R Chapman, Mason C Wilkinson, Isaac Nevarez-Saenz, Robert L Unckless

Publikováno v: PLoS Genetics, Vol 20, Iss 3, p e1011155 (2024)

Antimicrobial peptides (AMPs) are at the interface of interactions between hosts and microbes and are therefore expected to be rapidly evolving in a coevolutionary arms race with pathogens. In contrast, previous work demonstrated that insect AMPs ten

Externí odkaz: https://doaj.org/article/23ff312ea92f4f8f934e01f14f099829

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

A protein secreted by the Salmonella type III secretion system controls needle filament assembly

Autor: Junya Kato, Supratim Dey, Jose E Soto, Carmen Butan, Mason C Wilkinson, Roberto N De Guzman, Jorge E Galan

Publikováno v: eLife, Vol 7 (2018)

Type III protein secretion systems (T3SS) are encoded by several pathogenic or symbiotic bacteria. The central component of this nanomachine is the needle complex. Here we show in a Salmonella Typhimurium T3SS that assembly of the needle filament of

Externí odkaz: https://doaj.org/article/0b4e2ae158644ceb800dce215a709b3c

Zobrazit plný text záznamu

A single amino acid polymorphism in natural Metchnikowin alleles of Drosophila results in systemic immunity and life history tradeoffs

Autor: Jessamyn I. Perlmutter, Joanne R. Chapman, Mason C. Wilkinson, Isaac Nevarez-Saenz, Robert L. Unckless

Publikováno v: bioRxiv

Antimicrobial peptides (AMPs) are at the interface of interactions between hosts and microbes and are therefore expected to be fast evolving in a coevolutionary arms race with pathogens. In contrast, previous work demonstrated that one AMP, Metchikow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80bee8718ba7ec6663904e7161a0fe4b
https://europepmc.org/articles/PMC9882182/

Zobrazit plný text záznamu

Molecular simulations reveal a mechanism for enhanced allosteric coupling between voltage-sensor and pore domains in KCNQ1 explaining its activation by ML277

Autor: Georg Kuenze, Carlos G. Vanoye, Mason C. Wilkinson, Reshma R. Desai, Sneha Adusumilli, Charles R. Sanders, Alfred L. George, Jens Meiler

The voltage-gated potassium channel KCNQ1 (KV7.1) is important for the repolarizing phase of the cardiac action potential. Activators of KCNQ1 may provide a strategy for the pharmacological treatment of congenital long QT syndrome, a genetic disorder

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ddb51d78639b0d4eb552b681ceef5e0
https://doi.org/10.1101/2022.05.31.494217

Zobrazit plný text záznamu

Verteporfin is a substrate-selective γ-secretase inhibitor that binds the amyloid precursor protein transmembrane domain

Autor: Manuel A. Castro, Kristine F. Parson, Ilyas Beg, Mason C. Wilkinson, Kamila Nurmakova, Iliana Levesque, Markus W. Voehler, Michael S. Wolfe, Brandon T. Ruotolo, Charles R. Sanders

Publikováno v: Journal of Biological Chemistry. 298:101792

This work reports substrate-selective inhibition of a protease with broad substrate specificity based on direct binding of a small-molecule inhibitor to the substrate. The target for these studies was γ-secretase protease, which cleaves dozens of di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8248788c724b6d4de70958db33e2c58d
https://doi.org/10.1016/j.jbc.2022.101792

Zobrazit plný text záznamu