Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer.

Autor: Cui Zhou D; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; McDonnell Genome Institute, Washington University in St Louis, St Louis, MO, USA., Jayasinghe RG; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; McDonnell Genome Institute, Washington University in St Louis, St Louis, MO, USA., Chen S; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; McDonnell Genome Institute, Washington University in St Louis, St Louis, MO, USA., Herndon JM; Department of Surgery, Washington University in St Louis, St Louis, MO, USA.; Siteman Cancer Center, Washington University in St Louis, St Louis, MO, USA., Iglesia MD; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; McDonnell Genome Institute, Washington University in St Louis, St Louis, MO, USA., Navale P; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; Department of Pathology and Immunology, Washington University in St Louis, St Louis, MO, USA., Wendl MC; McDonnell Genome Institute, Washington University in St Louis, St Louis, MO, USA.; Department of Genetics, Washington University in St Louis, St Louis, MO, USA.; Department of Mathematics, Washington University in St Louis, St Louis, MO, USA., Caravan W; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; McDonnell Genome Institute, Washington University in St Louis, St Louis, MO, USA., Sato K; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; McDonnell Genome Institute, Washington University in St Louis, St Louis, MO, USA., Storrs E; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; McDonnell Genome Institute, Washington University in St Louis, St Louis, MO, USA., Mo CK; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; McDonnell Genome Institute, Washington University in St Louis, St Louis, MO, USA., Liu J; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; McDonnell Genome Institute, Washington University in St Louis, St Louis, MO, USA., Southard-Smith AN; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; McDonnell Genome Institute, Washington University in St Louis, St Louis, MO, USA., Wu Y; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; McDonnell Genome Institute, Washington University in St Louis, St Louis, MO, USA., Naser Al Deen N; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; McDonnell Genome Institute, Washington University in St Louis, St Louis, MO, USA., Baer JM; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; Department of Pathology and Immunology, Washington University in St Louis, St Louis, MO, USA., Fulton RS; McDonnell Genome Institute, Washington University in St Louis, St Louis, MO, USA., Wyczalkowski MA; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; McDonnell Genome Institute, Washington University in St Louis, St Louis, MO, USA., Liu R; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; McDonnell Genome Institute, Washington University in St Louis, St Louis, MO, USA., Fronick CC; McDonnell Genome Institute, Washington University in St Louis, St Louis, MO, USA., Fulton LA; McDonnell Genome Institute, Washington University in St Louis, St Louis, MO, USA., Shinkle A; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; McDonnell Genome Institute, Washington University in St Louis, St Louis, MO, USA., Thammavong L; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; McDonnell Genome Institute, Washington University in St Louis, St Louis, MO, USA., Zhu H; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; McDonnell Genome Institute, Washington University in St Louis, St Louis, MO, USA., Sun H; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; McDonnell Genome Institute, Washington University in St Louis, St Louis, MO, USA., Wang LB; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; McDonnell Genome Institute, Washington University in St Louis, St Louis, MO, USA., Li Y; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; McDonnell Genome Institute, Washington University in St Louis, St Louis, MO, USA., Zuo C; Department of Medicine, Washington University in St Louis, St Louis, MO, USA., McMichael JF; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; McDonnell Genome Institute, Washington University in St Louis, St Louis, MO, USA., Davies SR; Department of Surgery, Washington University in St Louis, St Louis, MO, USA., Appelbaum EL; McDonnell Genome Institute, Washington University in St Louis, St Louis, MO, USA., Robbins KJ; Department of Surgery, Washington University in St Louis, St Louis, MO, USA.; Siteman Cancer Center, Washington University in St Louis, St Louis, MO, USA., Chasnoff SE; Department of Surgery, Washington University in St Louis, St Louis, MO, USA., Yang X; Department of Medicine, Washington University in St Louis, St Louis, MO, USA., Reeb AN; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; Department of Otolaryngology-Head & Neck Surgery, Washington University in St Louis, St Louis, MO, USA., Oh C; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; McDonnell Genome Institute, Washington University in St Louis, St Louis, MO, USA., Serasanambati M; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; McDonnell Genome Institute, Washington University in St Louis, St Louis, MO, USA., Lal P; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; McDonnell Genome Institute, Washington University in St Louis, St Louis, MO, USA., Varghese R; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; McDonnell Genome Institute, Washington University in St Louis, St Louis, MO, USA., Mashl JR; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; McDonnell Genome Institute, Washington University in St Louis, St Louis, MO, USA., Ponce J; McDonnell Genome Institute, Washington University in St Louis, St Louis, MO, USA., Terekhanova NV; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; McDonnell Genome Institute, Washington University in St Louis, St Louis, MO, USA., Yao L; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; McDonnell Genome Institute, Washington University in St Louis, St Louis, MO, USA., Wang F; Department of Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Chen L; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Schnaubelt M; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Lu RJ; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; McDonnell Genome Institute, Washington University in St Louis, St Louis, MO, USA., Schwarz JK; Siteman Cancer Center, Washington University in St Louis, St Louis, MO, USA.; Department of Radiation Oncology, Washington University in St Louis, St Louis, MO, USA.; Department of Cell Biology and Physiology, Washington University in St Louis, St Louis, MO, USA., Puram SV; Department of Otolaryngology-Head & Neck Surgery, Washington University in St Louis, St Louis, MO, USA., Kim AH; Siteman Cancer Center, Washington University in St Louis, St Louis, MO, USA.; Department of Neurological Surgery, Washington University in St Louis, St Louis, MO, USA., Song SK; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; Department of Radiology, Washington University in St Louis, St Louis, MO, USA., Shoghi KI; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; Department of Radiology, Washington University in St Louis, St Louis, MO, USA., Lau KS; Department of Cell and Developmental Biology and Epithelial Biology Center, Vanderbilt University School of Medicine, Vanderbilt, TN, USA., Ju T; Department of Computer Science and Engineering, Washington University in St Louis, St Louis, MO, USA., Chen K; Department of Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Chatterjee D; Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Hawkins WG; Department of Surgery, Washington University in St Louis, St Louis, MO, USA.; Siteman Cancer Center, Washington University in St Louis, St Louis, MO, USA., Zhang H; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Achilefu S; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; Department of Radiology, Washington University in St Louis, St Louis, MO, USA., Chheda MG; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; Siteman Cancer Center, Washington University in St Louis, St Louis, MO, USA., Oh ST; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; Department of Pathology and Immunology, Washington University in St Louis, St Louis, MO, USA., Gillanders WE; Department of Surgery, Washington University in St Louis, St Louis, MO, USA.; Siteman Cancer Center, Washington University in St Louis, St Louis, MO, USA., Chen F; Department of Medicine, Washington University in St Louis, St Louis, MO, USA., DeNardo DG; Department of Medicine, Washington University in St Louis, St Louis, MO, USA. ddenardo@wustl.edu.; Siteman Cancer Center, Washington University in St Louis, St Louis, MO, USA. ddenardo@wustl.edu.; Department of Pathology and Immunology, Washington University in St Louis, St Louis, MO, USA. ddenardo@wustl.edu., Fields RC; Department of Surgery, Washington University in St Louis, St Louis, MO, USA. rcfields@wustl.edu.; Siteman Cancer Center, Washington University in St Louis, St Louis, MO, USA. rcfields@wustl.edu., Ding L; Department of Medicine, Washington University in St Louis, St Louis, MO, USA. lding@wustl.edu.; McDonnell Genome Institute, Washington University in St Louis, St Louis, MO, USA. lding@wustl.edu.; Siteman Cancer Center, Washington University in St Louis, St Louis, MO, USA. lding@wustl.edu.; Department of Genetics, Washington University in St Louis, St Louis, MO, USA. lding@wustl.edu.

Publikováno v: Nature genetics [Nat Genet] 2022 Sep; Vol. 54 (9), pp. 1390-1405. Date of Electronic Publication: 2022 Aug 22.