Výsledky vyhledávání - "Masheika L. James"

Hyperoxia Induces Intracellular Acidification in Neonatal Mouse Lung Fibroblasts: Real-Time Investigation Using Plasmonically Enhanced Raman Spectroscopy

Autor: Namasivayam Ambalavanan, Tamas Jilling, Mostafa A. El-Sayed, Masheika L. James, James A. Mobley, Steven M. Hira, Sajanlal R. Panikkanvalappil

Publikováno v: Journal of the American Chemical Society. 138:3779-3788

It is important to understand the molecular mechanisms underlying oxygen toxicity, which contributes to multiple human disorders. The archetype model of oxygen toxicity is neonatal lung injury induced by hyperoxia exposure. Here, we utilized plasmoni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84d7c7fde5ce08d1ba5c05c4d0cd7465
https://doi.org/10.1021/jacs.5b13177

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CFTR dysfunction increases endoglin and TGF-β signaling in airway epithelia

Autor: William T. Harris, Namasivayam Ambalavanan, Weifeng Zhang, Masheika L. James, Brian Halloran, Stephanie B. Wall, Changchun Ren, Teodora Nicola, Mark MacEwen, Tatjana Coric, Farruk M. Lutful Kabir

Publikováno v: Physiological Reports

Endoglin (ENG) regulates signaling by transforming growth factor‐β (TGF‐β), a genetic modifier of cystic fibrosis (CF) lung disease severity. We hypothesized that ENG mediates TGF‐β pathobiology in CF airway epithelia. Comparing CF and non�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::731b243ac67f6ae9e312b32a5249d00f
https://doi.org/10.14814/phy2.13977

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VARA attenuates hyperoxia-induced impaired alveolar development and lung function in newborn mice

Autor: Namasivayam Ambalavanan, Chad Steele, Masheika L. James, Teodora Nicola, A. Catharine Ross

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 304:L803-L812

We have recently shown that a combination of vitamin A (VA) and retinoic acid (RA) in a 10:1 molar ratio (VARA) synergistically increases lung retinoid content in newborn rodents, more than either VA or RA alone in equimolar amounts. We hypothesized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::879ccb46834fe9d61d2603016ae8aefa
https://doi.org/10.1152/ajplung.00257.2012

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Transforming growth factor-β regulates endothelin-1 signaling in the newborn mouse lung during hypoxia exposure

Autor: Yiu-Fai Chen, Arlene Bulger, Suzanne Oparil, Wei Zhang, Namasivayam Ambalavanan, Nelida Olave, Teodora Nicola, Masheika L. James

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 302:L857-L865

We have previously shown that inhibition of transforming growth factor-β (TGF-β) signaling attenuates hypoxia-induced inhibition of alveolar development and abnormal pulmonary vascular remodeling in the newborn mice and that endothelin-A receptor (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e1af3039cae1ff41765e26244a7115
https://doi.org/10.1152/ajplung.00258.2011

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Vitamin A and Retinoic Acid Act Synergistically to Increase Lung Retinyl Esters During Normoxia and Reduce Hyperoxic Lung Injury in Newborn Mice

Autor: Joseph B. Philips, Namasivayam Ambalavanan, Masheika L. James, Arlene Bulger, A. Catharine Ross

Publikováno v: Pediatric Research. 67:591-597

We have shown that vitamin A (VA) and retinoic acid (RA) synergistically increase lung retinyl ester content in neonatal rats. To confirm if this biochemical synergism attenuates early neonatal hyperoxic lung injury in mice, we exposed newborn C57BL/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6a3c6dd1729fa58c427b8ba81066507
https://doi.org/10.1203/pdr.0b013e3181dbac3d

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Hypoxia-induced inhibition of lung development is attenuated by the peroxisome proliferator-activated receptor-γ agonist rosiglitazone

Autor: Namasivayam Ambalavanan, Wei Zhang, Virender K. Rehan, Brian Halloran, Masheika L. James, Nelida Olave, Teodora Nicola, Yiu-Fai Chen, Arlene Bulger, Suzanne Oparil

Publikováno v: American journal of physiology. Lung cellular and molecular physiology. 301(1)

Hypoxia enhances transforming growth factor-β (TGF-β) signaling, inhibiting alveolar development and causing abnormal pulmonary arterial remodeling in the newborn lung. We hypothesized that, during chronic hypoxia, reduced peroxisome proliferator-a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b5c1a26e33b38395ff5b4ffd35a9d4a
https://pubmed.ncbi.nlm.nih.gov/21531777

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Loss of Thy-1 inhibits alveolar development in the newborn mouse lung

Autor: Timothy A. Williams, Arlene Bulger, Namasivayam Ambalavanan, James S. Hagood, Lisa M. Schwiebert, Teodora Nicola, Matthew M. Hewitt, Suzanne Oparil, Mark MacEwen, Yiu-Fai Chen, Masheika L. James

Transforming growth factor (TGF)-β mediates hypoxia-induced inhibition of alveolar development in the newborn lung. TGF-β is regulated primarily at the level of activation of latent TGF-β. Fibroblasts expressing Thy-1 (CD90) inhibit TGF-β activat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbd26e074b46320118d26e8acc5e0ef1
https://europepmc.org/articles/PMC2681351/

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