Zobrazeno 1 - 10
of 15 971
pro vyhledávání: '"Mascola A"'
Autor:
Maria P. Lemos, Rena D. Astronomo, Yunda Huang, Sandeep Narpala, Madhu Prabhakaran, Philipp Mann, Carmen A. Paez, Yiwen Lu, Gregory J. Mize, Hayley Glantz, Katharine Westerberg, Hunter Colegrove, Kimberly S. Smythe, Minggang Lin, Robert H. Pierce, Julia Hutter, Ian Frank, John R. Mascola, Adrian B. McDermott, Linda-Gail Bekker, M. Juliana McElrath
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract To prevent sexually-acquired HIV-1 infection by immunoprophylaxis, effective concentrations of broadly neutralizing antibodies are likely needed at mucosal sites of exposure. Here, we examine the biodistribution of monoclonal antibody VRC01
Externí odkaz:
https://doaj.org/article/eb93619de66746c7bd1926ca5ba2800f
Autor:
Hanks, Patrick, Lenarčič, Simon
Publikováno v:
Dictionary of American Family Names, 2 ed., 2022.
Externí odkaz:
http://www.oxfordreference.com/view/10.1093/acref/9780190245115.001.0001/acref-9780190245115-e-47489
Autor:
Joseph P. Casazza, Amelia R. Hofstetter, Pamela J. M. Costner, LaSonji A. Holman, Cynthia S. Hendel, Alicia T. Widge, Richard L. Wu, William R. Whalen, Jennifer Cunningham, Anita Arthur, Xiaolin Wang, Abidemi Ola, Jamie Saunders, Floreliz Mendoza, Laura Novik, Maria C. Burgos Florez, Ana M. Ortega-Villa, Preeti J. Apte, Larisa Strom, Lu Wang, Marjaan Imam, Manjula Basappa, Mursal Naisan, Mike Castro, Jessica F. Trost, Sandeep R. Narpala, Hillary A. Vanderven, Galina V. Yamshchikov, Nina M. Berkowitz, Ingelise J. Gordon, Sarah H. Plummer, Diane L. Wycuff, Sandra Vazquez, Rebecca A. Gillespie, Adrian Creanga, William C. Adams, Kevin Carlton, Jason G. Gall, Adrian B. McDermott, Leonid A. Serebryannyy, Katherine V. Houser, Richard A. Koup, Barney S. Graham, Julie E. Ledgerwood, John R. Mascola, Theodore C. Pierson, Sarah F. Andrews, Masaru Kanekiyo, Lesia K. Dropulic, The VRC 323 study team
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-10 (2024)
Abstract The relative conservation of the influenza hemagglutinin (HA) stem compared to that of the immunodominant HA head makes the HA stem an attractive target for broadly protective influenza vaccines. Here we report the first-in-human, dose-escal
Externí odkaz:
https://doaj.org/article/96bea20f4a6e46d8a78a3f7c6943f262
Autor:
Joana Dias, Giulia Fabozzi, Slim Fourati, Xuejun Chen, Cuiping Liu, David R. Ambrozak, Amy Ransier, Farida Laboune, Jianfei Hu, Wei Shi, Kylie March, Anna A. Maximova, Stephen D. Schmidt, Jakob Samsel, Chloe A. Talana, Keenan Ernste, Sung Hee Ko, Margaret E. Lucas, Pierce E. Radecki, Kristin L. Boswell, Yoshiaki Nishimura, John-Paul Todd, Malcolm A. Martin, Constantinos Petrovas, Eli A. Boritz, Nicole A. Doria-Rose, Daniel C. Douek, Rafick-Pierre Sékaly, Jeffrey D. Lifson, Mangaiarkarasi Asokan, Lucio Gama, John R. Mascola, Amarendra Pegu, Richard A. Koup
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Anti-HIV-1 broadly neutralizing antibodies (bNAbs) have the dual potential of mediating virus neutralization and antiviral effector functions through their Fab and Fc domains, respectively. So far, bNAbs with enhanced Fc effector functions i
Externí odkaz:
https://doaj.org/article/bf19edfc45874c86ab18e09d0df26155
Autor:
Evan M. Cale, Chen-Hsiang Shen, Adam S. Olia, Nathan A. Radakovich, Reda Rawi, Yongping Yang, David R. Ambrozak, Anthony K. Bennici, Gwo-Yu Chuang, Emma D. Crooks, Jefferson I. Driscoll, Bob C. Lin, Mark K. Louder, Patrick J. Madden, Michael A. Messina, Keiko Osawa, Guillaume B.E. Stewart-Jones, Raffaello Verardi, Zoe Vrakas, Danielle Xie, Baoshan Zhang, James M. Binley, Mark Connors, Richard A. Koup, Theodore C. Pierson, Nicole A. Doria-Rose, Peter D. Kwong, John R. Mascola, Jason Gorman
Publikováno v:
Cell Reports, Vol 43, Iss 12, Pp 115010- (2024)
Summary: Antibodies that target the gp120-gp41 interface of the HIV-1 envelope (Env) trimer comprise a commonly elicited category of broadly neutralizing antibodies (bNAbs). Here, we isolate and characterize VRC44, a bNAb lineage with up to 52% neutr
Externí odkaz:
https://doaj.org/article/c5c019e56e4740428a301c25969c24c2
Autor:
Myra Happe, Amelia R. Hofstetter, Jing Wang, Galina V. Yamshchikov, LaSonji A. Holman, Laura Novik, Larisa Strom, Francis Kiweewa, Salim Wakabi, Monica Millard, Colleen F. Kelley, Sarah Kabbani, Srilatha Edupuganti, Allison Beck, Florence Kaltovich, Tamar Murray, Susanna Tsukerman, Derick Carr, Carl Ashman, Daphne A. Stanley, Aurélie Ploquin, Robert T. Bailer, Richard Schwartz, Fatim Cham, Allan Tindikahwa, Zonghui Hu, Ingelise J. Gordon, Nadine Rouphael, Katherine V. Houser, Emily E. Coates, Barney S. Graham, Richard A. Koup, John R. Mascola, Nancy J. Sullivan, Merlin L. Robb, Julie A. Ake, Kirsten E. Lyke, Mark J. Mulligan, Julie E. Ledgerwood, Hannah Kibuuka, the VRC 208 and RV 422 study team
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-11 (2024)
Abstract Ebola virus disease (EVD) is a filoviral infection caused by virus species of the Ebolavirus genus including Zaire ebolavirus (EBOV) and Sudan ebolavirus (SUDV). We investigated the safety and immunogenicity of a heterologous prime-boost reg
Externí odkaz:
https://doaj.org/article/a738fdd17f884be498b68c55cc2e29cd
Autor:
Zhang, Peng 1, 9, 10, ∗, Gorman, Jason 2, 3, 10, Tsybovsky, Yaroslav 4, Lu, Maolin 5, Liu, Qingbo 1, 6, Gopan, Vinay 1, Singh, Mamta 1, Lin, Yin 1, Miao, Huiyi 1, Seo, Yuna 1, Kwon, Alice 1, Olia, Adam S. 2, Chuang, Gwo-Yu 2, Geng, Hui 2, Lai, Yen-Ting 2, Zhou, Tongqing 2, Mascola, John R. 2, 7, Mothes, Walther 8, Kwong, Peter D. 2, Lusso, Paolo 1, 11, ∗∗
Publikováno v:
In Cell Reports 27 August 2024 43(8)
Autor:
Stephen R Walsh, Cynthia L Gay, Shelly T Karuna, Ollivier Hyrien, Timothy Skalland, Kenneth H Mayer, Magdalena E Sobieszczyk, Lindsey R Baden, Paul A Goepfert, Carlos Del Rio, Guiseppe Pantaleo, Philip Andrew, Carissa Karg, Zonglin He, Huiyin Lu, Carmen A Paez, Jane A G Baumblatt, Laura L Polakowski, Wairimu Chege, Maija A Anderson, Sophie Janto, Xue Han, Yunda Huang, Julie Dumond, Margaret E Ackerman, Adrian B McDermott, Britta Flach, Estelle Piwowar-Manning, Kelly Seaton, Georgia D Tomaras, David C Montefiori, Lucio Gama, John R Mascola, HVTN 127/HPTN 087 Study Team
Publikováno v:
PLoS Medicine, Vol 21, Iss 6, p e1004329 (2024)
BackgroundBroadly neutralizing antibodies (bnAbs) are a promising approach for HIV-1 prevention. In the Antibody Mediated Prevention (AMP) trials, a CD4-binding site targeting bnAb, VRC01, administered intravenously (IV), demonstrated 75% prevention
Externí odkaz:
https://doaj.org/article/4be70ce338214ab0a34f240e9ededde1
Autor:
Jason Gorman, Crystal Sao-Fong Cheung, Zhijian Duan, Li Ou, Maple Wang, Xuejun Chen, Cheng Cheng, Andrea Biju, Yaping Sun, Pengfei Wang, Yongping Yang, Baoshan Zhang, Jeffrey C. Boyington, Tatsiana Bylund, Sam Charaf, Steven J. Chen, Haijuan Du, Amy R. Henry, Tracy Liu, Edward K. Sarfo, Chaim A. Schramm, Chen-Hsiang Shen, Tyler Stephens, I-Ting Teng, John-Paul Todd, Yaroslav Tsybovsky, Raffaello Verardi, Danyi Wang, Shuishu Wang, Zhantong Wang, Cheng-Yan Zheng, Tongqing Zhou, Daniel C. Douek, John R. Mascola, David D. Ho, Mitchell Ho, Peter D. Kwong
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Lassa virus (LASV) infection is expanding outside its traditionally endemic areas in West Africa, posing a pandemic biothreat. LASV-neutralizing antibodies, moreover, have proven difficult to elicit. To gain insight into LASV neutralization,
Externí odkaz:
https://doaj.org/article/83f13599c74f445ebfcd24f0985fef96
Autor:
Bailey B. Banach, Sergei Pletnev, Adam S. Olia, Kai Xu, Baoshan Zhang, Reda Rawi, Tatsiana Bylund, Nicole A. Doria-Rose, Thuy Duong Nguyen, Ahmed S. Fahad, Myungjin Lee, Bob C. Lin, Tracy Liu, Mark K. Louder, Bharat Madan, Krisha McKee, Sijy O’Dell, Mallika Sastry, Arne Schön, Natalie Bui, Chen-Hsiang Shen, Jacy R. Wolfe, Gwo-Yu Chuang, John R. Mascola, Peter D. Kwong, Brandon J. DeKosky
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The HIV-1 fusion peptide (FP) represents a promising vaccine target, but global FP sequence diversity among circulating strains has limited anti-FP antibodies to ~60% neutralization breadth. Here we evolve the FP-targeting antibody VRC34.01
Externí odkaz:
https://doaj.org/article/e636e8ff307e4e158f7f9667c39522e1