Výsledky vyhledávání - "Masayuki Utsugi"

2'-N-Alkylaminocarbonyl-2'-amino-LNA: Synthesis, duplex stability, nuclease resistance, and in vitro anti-microRNA activity

Autor: Tomo Takegawa-Araki, Kai Yasukawa, Norihiko Iwazaki, Masayuki Utsugi, Hiroyuki Furukawa, Shinji Kumagai, Hiroaki Sawamoto, Satoshi Obika

Publikováno v: Bioorganicmedicinal chemistry. 78

2'-Amino-LNA has the potential to acquire various functions through chemical modification at the 2'-nitrogen atom. This study focused on 2'-N-alkylaminocarbonyl 2'-amino-LNA, which is a derivative of 2'-amino-LNA. We evaluated its practical usefulnes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c4a99e9c3f60892e25398e0925cb7ba
https://pubmed.ncbi.nlm.nih.gov/36580743

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Scalable Process Design for a PDE10A Inhibitor Consisting of Pyrazolopyrimidine and Quinoxaline as Key Units

Autor: Masuhiro Sugino, Takehiro Nanjo, Ryo Kobayashi, Eiji Toyofuku, Shinichi Izumoto, Noriaki Moriyama, Masayuki Utsugi, Takafumi Yamagami, Yoichi Kadoh, Hajime Hiramatsu, Hideki Horiuchi, Yasunori Moritani, Eiji Kawanishi

Publikováno v: Organic Process Research & Development. 23:578-587

In this study, research and development for the synthetic process of a PDE10A inhibitor are described; in particular, an efficient regioselective construction of the quinoxaline unit, a cost-effective pyrazolo[1,5-a]pyrimidine formation, and a cost-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec51d299ba796e24997f1576adcc473e
https://doi.org/10.1021/acs.oprd.9b00068

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Practical and Scalable Synthesis of a Benzonitrile Derivative via Palladium-Catalyzed Cyanation with Potassium Ferrocyanide

Autor: Hiroki Ozawa, Eiji Toyofuku, Masayuki Utsugi, Masanori Hatsuda

Publikováno v: Organic Process Research & Development. 18:693-698

A practical and reproducible synthetic method for the preparation of a benzonitrile derivative (1) from an aryl bromide (2) via Pd-catalyzed cyanation was established with dimethylacetamide (DMAc)–toluene as a mixed solvent. Optimization was examin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::738f2cd55c416e0a317c47c9b40e8716
https://doi.org/10.1021/op400204g

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Highly Diastereoselective Esterification of Ketenes Generated In Situ from Acyl Chlorides with (R)-Pantolactone Derivatives

Autor: Takafumi Yamagami, Ryo Kobayashi, Masanori Hatsuda, Masayuki Utsugi, Yasunori Moritani

Publikováno v: European Journal of Organic Chemistry. 2013:7467-7470

Our mechanistic investigations have revealed that Et3N is a key requirement for the highly diastereoselective formation of esters from the corresponding acyl chlorides with (R)-pantolactone via ketene-derived complexes. Furthermore, we have discovere

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db34a672d414f3a304d77089c82e2ec7
https://doi.org/10.1002/ejoc.201301383

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Synthetic studies on the taxane skeleton: effective construction of eight-membered carbocyclic ring by palladium-catalyzed intramolecular α-alkenylation of a methyl ketone

Autor: Yasuaki Kamada, Masahisa Nakada, Masayuki Utsugi

Publikováno v: Tetrahedron Letters. 49:4754-4757

A new method for the construction of the eight-membered carbocyclic ring in the taxane skeleton is described. The palladium-catalyzed intramolecular α-alkenylation of a methyl ketone effectively constructed the eight-membered carbocyclic ring in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5fbf0a7b9a2fac475a52f741f18d8c27
https://doi.org/10.1016/j.tetlet.2008.05.105

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Construction of the taxane skeleton via the stereoselective conjugate addition of cyanide and the intramolecular B-alkyl Suzuki–Miyaura coupling reaction

Autor: Hidetoshi Miyamoto, Yasuaki Kamada, Masahisa Nakada, Masayuki Utsugi

Publikováno v: Tetrahedron Letters. 48:6868-6872

Construction of the taxane skeleton via the stereoselective conjugate addition of cyanide and the intramolecular B-alkyl Suzuki–Miyaura coupling reaction is described. A conjugate addition of cyanide to enone 17 proceeded diastereoselectively to pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb81cdb0aff5070e5aff930e7ec0833e
https://doi.org/10.1016/j.tetlet.2007.07.179

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Synthetic Studies on Taxol: Highly Stereoselective Construction of the Taxol C-Ring via SN2‘ Reduction of an Allylic Phosphonium Salt

Autor: Masahisa Nakada, Masayuki Utsugi, Masayuki Miyano

Publikováno v: Organic Letters. 8:2973-2976

[reaction: see text] The highly stereoselective construction of the C3 stereogenic center of the taxol C-ring is described. The trans isomer at the C3-C8 position of the taxol C-ring, which is required for the total synthesis, as well as its diastere

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a74ca48e0434d904470dd2f2e515e491
https://doi.org/10.1021/ol0608606

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Development of silicon-tethered anionic reaction and its application to the synthesis of chiral A-ring moieties of Taxol™

Autor: Hatsuo Kawada, Mitsuhiro Iwamoto, Masayuki Miyano, Masayuki Utsugi, Masahisa Nakada

Publikováno v: Tetrahedron Letters. 45:8647-8651

Silicon-tethered intramolecular nucleophilic additions of a hydroxymethyl unit to ketones in β-hydroxyketones have been developed. The product obtained by this protocol was successfully converted to chiral A-ring moieties of Taxol™. Also developed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::841b3b7da456295718734e824b461834
https://doi.org/10.1016/j.tetlet.2004.09.143

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