Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Masayuki Nagayoshi"'
Autor:
Christopher Blackburn, Tricia J. Vos, Jane X. Liu, Masayuki Nagayoshi, Bheemashankar Kulkarni, Juliet A Williams, Saurabh Menon, Alexandra E. Gould, Matthew O. Duffey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4795-4799
A high throughput screen identified N-aroylpyrazoline 1 as a selective inhibitor of the V600E mutant of B-Raf kinase. Parallel synthesis of acyl, aroyl, and sulfonyl derivatives led to the identification of several potent inhibitors in both enzymatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4056bfd643e1527ac5767e8b581e8c51
https://doi.org/10.1016/j.bmcl.2010.06.110
https://doi.org/10.1016/j.bmcl.2010.06.110
Publikováno v:
The Journal of Organic Chemistry. 63:3379-3385
N,N‘-Difluoro-2,2‘-, -2,4‘-, -3,3‘-, -4,4‘-bipyridinium and substituted N,N‘-difluoro-2,2‘-bipyridinium bis(triflates), bis(tetrafluoroborates), bis(hexafluorophosphates), and bis(hexafluoroantimon...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa8592b4af2fab6ce6921fa0febdca67
https://doi.org/10.1021/jo972338q
https://doi.org/10.1021/jo972338q
Autor:
Teruo Umemoto, Masayuki Nagayoshi
Publikováno v:
Bulletin of the Chemical Society of Japan. 69:2287-2295
A series of N,N′-difluoro-1,4-diazoniabicyclo[2.2.2]octane salts were synthesized in a pure form by the fluorination of 1,4-diazabicyclo[2.2.2]octane with F2 diluted with N2 in the presence of a Bronsted acid in fluoro alcohol or acetonitrile or by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ee63597f42d38286a7cba7e18b1467d
https://doi.org/10.1246/bcsj.69.2287
https://doi.org/10.1246/bcsj.69.2287
Autor:
Masayuki Nagayoshi, Atsuko Fujii, Akira Hosomi, Naruyasu Ishibashi, Katsukiyo Miura, Makoto Hojo, Toshiharu Yanagi
Publikováno v:
Chemistry Letters. 23:719-722
Silylamines add to α,β-unsaturated aldehydes and ketones in 1,4-addition mode to generate amino-substituted silyl enol ethers without any catalysts. These easily isolable silyl enol ethers react with acetals and aldehydes in the presence of a Lewis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd062ade500d95e0ec7f06ad7957fc7f
https://doi.org/10.1246/cl.1994.719
https://doi.org/10.1246/cl.1994.719
Autor:
Masayuki Nagayoshi, Teruo Umemoto
Publikováno v:
ChemInform. 27
A series of N,N′-difluoro-1,4-diazoniabicyclo[2.2.2]octane salts were synthesized in a pure form by the fluorination of 1,4-diazabicyclo[2.2.2]octane with F2 diluted with N2 in the presence of a Bronsted acid in fluoro alcohol or acetonitrile or by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2af0b8d3bbd84cfbe394ef364fb1b901
https://doi.org/10.1002/chin.199651141
https://doi.org/10.1002/chin.199651141
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b108b96b8db5d979910063902cc69fd0
https://doi.org/10.1002/chin.199839149
https://doi.org/10.1002/chin.199839149
Autor:
Paul D. Greenspan, Susan Chen, Liting Ma, Jane X. Liu, Johnny J. Yang, Qin Zhang, Ruth Adams, Shih-Chung Huang, Bheemashankar Kulkarni, Ryan W. Chau, Masayuki Nagayoshi, Matthew O. Duffey, Shaoxia Yu, Christopher Blackburn, Khristofer Garcia, Katherine M. Galvin, Tricia J. Vos, Sean Harrison, R. Scott Rowland, Xu Tianlin, Steven P. Langston, Mi-Sook Kim, Saurabh Menon, Alexandra E. Gould
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(16)
The discovery of novel pyrazoline derivatives as B-Raf (V600E) inhibitors is described in this report. Chemical modification of the pyrazoline scaffold led to the development of SAR and identified potent and selective inhibitors of B-Raf (V600E). Det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcc87a8f685ce6fbace298975e618b85
https://pubmed.ncbi.nlm.nih.gov/20634068
https://pubmed.ncbi.nlm.nih.gov/20634068
Autor:
Nancy Bump, Cindy Q. Xia, Lawrence R. Dick, Paul Hales, Frank J. Bruzzese, Cynthia Barrett, Darshan S. Sappal, Kenneth M. Gigstad, Khristofer Garcia, Jane X. Liu, Christopher Blackburn, Jonathan L. Blank, Paul E. Fleming, Masayuki Nagayoshi, Michael D. Sintchak, Christopher Tsu, Matthew Jones, Xiansi Zhou
Publikováno v:
MedChemComm. 3:710
Inhibition of the proteasome by covalent inhibitors is a clinically proven anti-cancer therapy. We report here that dipeptides with a P3 neopentyl Asn residue are potent, reversible, non-covalent inhibitors selective for the chymotryptic activity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f31a337948e93755309d48a1aa562b07
https://doi.org/10.1039/c2md20060k
https://doi.org/10.1039/c2md20060k