Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Masayuki Miyano"'
Autor:
Youya Nakazawa, Masayuki Miyano, Shuntaro Tsukamoto, Hiroyuki Kogai, Akihiko Yamamoto, Kentaro Iso, Satoshi Inoue, Yoshinobu Yamane, Yuki Yabe, Hirotatsu Umihara, Junichi Taguchi, Tsuyoshi Akagi, Atsumi Yamaguchi, Minaho Koga, Kohta Toshimitsu, Toshifumi Hirayama, Yohei Mukai, Akihito Machinaga
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Pancreatic ductal adenocarcinoma (PDAC) has the worst prognosis of all cancers. To improve PDAC therapy, we establish screening systems based on organoid and co-culture technologies and find a payload of antibody–drug conjugate (ADC), a br
Externí odkaz:
https://doaj.org/article/f57f6b1549874630a2370ee41f1543e6
Autor:
Hiroshi, Kamiyama, Masayuki, Miyano, Daisuke, Ito, Takayuki, Kimura, Koji, Hagiwara, Hiroyuki, Kogai, Yosuke, Kaburagi, Yoshihiko, Kotake, Yasutaka, Takase
Publikováno v:
Chemical Biology & Drug Design. 101:727-739
The identification of biologically active target compounds and their binding proteins is important in mechanism-of-action studies for drug development. Additionally, the newly discovered binding proteins provide unforeseen ideas for novel drug discov
Publikováno v:
JAPANESE JOURNAL OF MULTIPHASE FLOW. 34:134-139
Autor:
Parasuraman Selvam, Patrick Bonnaud, Akira Miyamoto, Nobutoshi Aoki, Jun-ichi Saito, Ai Suzuki, Masayuki Miyano, Kuniaki Ara, Mark C. Williams
Publikováno v:
The Journal of Physical Chemistry B. 120:3527-3539
Suspension state of a titanium nanoparticle in the liquid sodium was quantum chemically characterized by comparing physical characteristics, viz., electronic state, viscosity, and surface tension, with those of liquid sodium. The exterior titanium at
Autor:
Shigehiko Sakamoto, Munehito Miyashita, Shinji Koike, Masayuki Miyano, Toshihiro Suzuki, Hiroaki Nagano
Publikováno v:
The Proceedings of The Manufacturing & Machine Tool Conference. :A02
Publikováno v:
The Proceedings of The Computational Mechanics Conference. :085
Publikováno v:
The Proceedings of The Computational Mechanics Conference. :086
Publikováno v:
Tetrahedron Letters. 54:1888-1892
Two short preparations of the taxol A-ring fragment are described: one via organocatalyzed α-aminoxylation and the other via Sharpless asymmetric dihydroxylation (SAD). The former approach affords the A-ring fragment in 10 steps, and the latter appr
Publikováno v:
Organic Letters. 8:2973-2976
[reaction: see text] The highly stereoselective construction of the C3 stereogenic center of the taxol C-ring is described. The trans isomer at the C3-C8 position of the taxol C-ring, which is required for the total synthesis, as well as its diastere
Publikováno v:
Tetrahedron Letters. 45:8647-8651
Silicon-tethered intramolecular nucleophilic additions of a hydroxymethyl unit to ketones in β-hydroxyketones have been developed. The product obtained by this protocol was successfully converted to chiral A-ring moieties of Taxol™. Also developed