Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Masayuki Kanki"'
Publikováno v:
Journal of Pharmacological Sciences, Vol 151, Iss 4, Pp 171-176 (2023)
ASP8062 is an orally available GABAB receptor positive allosteric modulator (PAM). This study assessed the potential of ASP8062 for treating opioid use disorder (OUD). Three rhesus monkeys were pretreated with ASP8062 (0.3, 1 or 3 mg/kg) by oral admi
Externí odkaz:
https://doaj.org/article/ed09f3019ecf440cb4dd646207ab770d
Autor:
Yukari Fujiwara, Dong-sik Ham, Byung Hyune Choi, Yat P. Tsui, James Ooi, Yoshie Tsurumaki, Tomohiro Yoneda, Feng-Cheng Chou, Pawan Gupta, Yongjun Liu, Takeshi Watanabe, Joo Y. Lee, Yuu Moriya, Yoshiteru Kamiyama, Chih-Yuan Ho, Kou Omura, Ling-Mei Wang, Kiyoko Bando, Guangyang Liu, Yohan Bae, Masayuki Kanki, Hiroshi Karasawa
Publikováno v:
Cytotherapy. 23:874-885
Background aims Cell-based regenerative medicine is an innovative field that can potentially alter the overall survival and quality of life of patients with devastating diseases. Several cell therapy products (CTPs) have been approved within the last
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cec5ced7926e933272f9d5b65367bad1
https://doi.org/10.1016/j.jcyt.2021.04.007
https://doi.org/10.1016/j.jcyt.2021.04.007
Autor:
Yu Yamaura1,2 yu.yamaura@astellas.com, Masayuki Kanki1, Daisuke Sasaki1, Miki Nakajima2,3, Akira Unami1
Publikováno v:
Journal of Toxicological Sciences. 2020, Vol. 45 Issue 8, p503-513. 11p.
Publikováno v:
Journal of Toxicological Sciences. Apr2016, Vol. 41 Issue 2, p281-292. 12p.
Publikováno v:
The Journal of Toxicological Sciences. 41:281-292
Several studies have successfully detected hepatocarcinogenicity in rats based on gene expression data. However, prediction of hepatocarcinogens with certain mechanisms of action (MOAs), such as enzyme inducers and peroxisome proliferator-activated r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ddc7c497fd1d4ecf6f8a62324fa11a7
https://doi.org/10.2131/jts.41.281
https://doi.org/10.2131/jts.41.281
Autor:
Kenjiro Tsubota1 kenjiro.tsubota@astellas.com, Masayuki Kanki1, Takahisa Noto1, Shunji Nakatsuji1, Yuji Oishi1, Masahiro Matsumoto1, Hiroyuki Nakayama2
Publikováno v:
Journal of Toxicological Sciences. Jun2015, Vol. 40 Issue 3, p413-425. 13p.
Autor:
Masahiro Matsumoto, Takahisa Noto, Yuji Oishi, Hiroyuki Nakayama, Kenjiro Tsubota, Masayuki Kanki, Shunji Nakatsuji
Publikováno v:
The Journal of Toxicological Sciences. 40:413-425
It is well-known that indomethacin (the cyclooxygenase 1 & 2 inhibitor) and RU486 (or mifepristone, the progesterone receptor antagonist) block follicular rupture in rats. To characterize genetic alterations in unruptured follicles, gene expression p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e79744e4326b88fb987ae4f79b1fd4a
https://doi.org/10.2131/jts.40.413
https://doi.org/10.2131/jts.40.413
Autor:
Shotaro Yamano, Hirokazu Tachibana, Eri Shimomura, He Fang, Satoko Kawachi, Naomi Ishii, Kumiko Tatsumi, Masayuki Kanki, Min Gi, Anna Kakehashi, Masaki Fujioka, Hideki Wanibuchi
Publikováno v:
The Journal of Toxicological Sciences. 40:647-656
Based on the findings of epidemiological studies in Japan that occupational exposure to 1,2-dichloropropane (1,2-DCP) was associated with increased cholangiocarcinomas, 1,2-DCP has recently been classified as being carcinogenic to humans (Group 1). H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8773ad72761c4ed1cac60547569f0ecf
https://doi.org/10.2131/jts.40.647
https://doi.org/10.2131/jts.40.647
Autor:
Keiichi Minami, Takeki Uehara, Ko Omura, Kunitoshi Mitsumori, Masayuki Kanki, Tetsuro Urushidani, Yuji Morikawa, Hitomi Hayashi, Atsushi Ono, Hiroshi Yamada
Publikováno v:
The Journal of Toxicological Sciences. 39:785-794
We previously reported a toxicogenomics-based prediction model for hepatocarcinogens in which the expression patterns of signature genes following repeated doses of either genotoxic or non genotoxic compounds were similar. Based on the results of our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b04f2ba8f864aceed6b02725050658bc
https://doi.org/10.2131/jts.39.785
https://doi.org/10.2131/jts.39.785
Autor:
Atsushi Ono, Masayuki Kanki, Ko Omura, Yuji Morikawa, Tetsuro Urushidani, Yasuo Ohno, Keiichi Minami, Takeki Uehara, Akira Horinouchi, Hiroshi Yamada
Publikováno v:
Scientific Data
MicroRNAs (miRNAs) are small (~22 nucleotide) noncoding RNAs that play pivotal roles in regulation of gene expression. The value of miRNAs as circulating biomarkers is now broadly recognized; such tissue-specific biomarkers can be used to monitor tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b899d51af13ff18f4bd34d9e3f40ece1
http://europepmc.org/articles/PMC4322570
http://europepmc.org/articles/PMC4322570