Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Masayuki, Otsuka"'
Autor:
Hideyuki Yamada, Mamoru Takada, Dhaval Ghone, Muhan Yu, Takeshi Nagashima, Hiroshi Fujimoto, Junta Sakakibara, Yoshie Hasegawa, Shintaro Takao, Akimitsu Yamada, Kazutaka Narui, Takashi Ishikawa, Aussie Suzuki, Masayuki Otsuka
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Eribulin (ERI), clinically utilized for locally advanced or metastatic breast tumors, has shown potential links to the immune system. Notably, the cGAS-STING pathway, a key component of innate immunity, has gained prominence. Yet, limited re
Externí odkaz:
https://doaj.org/article/d9f927eb17d74d8ba1ad43672d88807b
Autor:
Narmada, Balakrishnan Chakrapani, Khakpoor, Atefeh, Shirgaonkar, Niranjan, Narayanan, Sriram, Aw, Pauline Poh Kim, Singh, Malay, Ong, Kok Haur, Owino, Collins Oduor, Ng, Jane Wei Ting, Yew, Hui Chuing, Binte Mohamed Nasir, Nu Soibah, Au, Veonice Bijin, Sng, Reina, Kaliaperumal, Nivashini, Khine, Htet Htet Toe Wai, di Tocco, Francesca Casuscelli, Masayuki, Otsuka, Naikar, Shamita, Ng, Hui Xin, Chia, Su Li, Seah, Cindy Xin Yi, Alnawaz, Myra HJ., Wai, Chris Lee Yoon, Tay, Amy Yuh Ling, Mangat, Kamarjit Singh, Chew, Valerie, Yu, Weimiao, Connolly, John Edward, Periyasamy, Giridharan, Plissonnier, Marie-Laure, Levrero, Massimo, Lim, Seng Gee, DasGupta, Ramanuj
Publikováno v:
In Journal of Hepatology July 2024 81(1):42-61
Autor:
Shouko Hayama, Rikiya Nakamura, Takayuki Ishige, Takafumi Sangai, Masahiro Sakakibara, Hiroshi Fujimoto, Emi Ishigami, Takahito Masuda, Ayako Nakagawa, Ryotaro Teranaka, Satoshi Ota, Sakae Itoga, Naohito Yamamoto, Takeshi Nagashima, Masayuki Otsuka
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-10 (2023)
Abstract Background There is pressing needs to find the biomarker in the selection of neoadjuvant therapy in postmenopausal luminal breast cancer patients. We examined the hypothesis that PIK3CA mutations and low phosphatase and tensin homolog (PTEN)
Externí odkaz:
https://doaj.org/article/0c7fbaaf8c9747b2b95b0b619b492bb5
Autor:
Kensuke Sugiura, Yasunori Masuike, Kensuke Suzuki, Alice E. Shin, Nozomu Sakai, Hisahiro Matsubara, Masayuki Otsuka, Peter A. Sims, Christopher J. Lengner, Anil K. Rustgi
Publikováno v:
JCI Insight, Vol 8, Iss 14 (2023)
The RNA-binding protein LIN28B is overexpressed in over 30% of patients with colorectal cancer (CRC) and is associated with poor prognosis. In the present study, we unraveled a potentially novel mechanism by which LIN28B regulates colonic epithelial
Externí odkaz:
https://doaj.org/article/4cc16e72c1d5417fbecfca91adb61af1
Autor:
Marie J. Y. Reolo, Masayuki Otsuka, Justine Jia Wen Seow, Joycelyn Lee, Yun Hua Lee, Phuong H. D. Nguyen, Chun Jye Lim, Martin Wasser, Camillus Chua, Tony K. H. Lim, Wei Qiang Leow, Alexander Chung, Brian K. P. Goh, Pierce K. H. Chow, Ramanuj DasGupta, Joe Poh Sheng Yeong, Valerie Chew
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionDespite recent advances in immunotherapy for hepatocellular carcinoma (HCC), the overall modest response rate underscores the need for a better understanding of the tumor microenvironment (TME) of HCC. We have previously shown that CD38 i
Externí odkaz:
https://doaj.org/article/5a4cd342a33d48c3a5625cfed3c9b0ef
Autor:
Mamoru Takada, Taichi Fukushima, Sho Ozawa, Syuma Matsubara, Takeshi Suzuki, Ichiro Fukumoto, Toyoyuki Hanazawa, Takeshi Nagashima, Reiko Uruma, Masayuki Otsuka, Gaku Tanaka
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Healthcare providers are vulnerable to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) because of their close proximity to patients with coronavirus disease 2019. SARS-CoV-2 is mainly transmitted via direct and in
Externí odkaz:
https://doaj.org/article/a2410f01be944933be4ab4003fe8cc79
Autor:
Yuko Kusakabe, Tetsuhiro Chiba, Motohiko Oshima, Shuhei Koide, Ola Rizq, Kazumasa Aoyama, Junjie Ao, Tatsuya Kaneko, Hiroaki Kanzaki, Kengo Kanayama, Takahiro Maeda, Tomoko Saito, Ryo Nakagawa, Kazufumi Kobayashi, Soichiro Kiyono, Masato Nakamura, Sadahisa Ogasawara, Eiichiro Suzuki, Shingo Nakamoto, Shin Yasui, Rintaro Mikata, Ryosuke Muroyama, Tatsuo Kanda, Hitoshi Maruyama, Jun Kato, Naoya Mimura, Anqi Ma, Jian Jin, Yoh Zen, Masayuki Otsuka, Atsushi Kaneda, Atsushi Iwama, Naoya Kato
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Both EZH2 and its homolog EZH1 function as histone H3 Lysine 27 (H3K27) methyltransferases and repress the transcription of target genes. Dysregulation of H3K27 trimethylation (H3K27me3) plays an important role in the development and progres
Externí odkaz:
https://doaj.org/article/8eb58697caf4466e8a01b8253f2d212f
Autor:
Takashi Kurabuchi, U. Yanagi, Masayuki Ogata, Masayuki Otsuka, Naoki Kagi, Yoshihide Yamamoto, Motoya Hayashi, Shinichi Tanabe
Publikováno v:
Japan Architectural Review, Vol 4, Iss 4, Pp 608-620 (2021)
Abstract It is still undetermined if the main infection route of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the virus that leads to coronavirus disease 2019 (COVID‐19), is infection through droplet, contact, or airborne trans
Externí odkaz:
https://doaj.org/article/7fb7dd139d1a4353bbe10d65d1bee8de
Autor:
Miki Uwatoko, Koki Tokunaga, Mako Kawano, Masahisa Kamimura, Yutaro Ibi, Masayuki Otsuka, Masato Minami, Haruhito Yoshimine, Fujio Hamada, Akio Ido
Publikováno v:
Renal Replacement Therapy, Vol 6, Iss 1, Pp 1-7 (2020)
Abstract Background Neurological symptoms sometimes occur in hemodialysis patients, with causes including cerebral infarction, cerebral hemorrhaging, meningitis, and encephalitis. Dialysis disequilibrium syndrome (DDS) is widely known as a complicati
Externí odkaz:
https://doaj.org/article/7d380874688f48b8825a8dacfc68cad2
Autor:
Shigeo Yasuda, MD, PhD, Hirotoshi Kato, MD, PhD, Hiroshi Imada, MD, PhD, Yuka Isozaki, MD, PhD, Goro Kasuya, MD, PhD, Hirokazu Makishima, MD, PhD, Hiroshi Tsuji, MD, PhD, Daniel K. Ebner, BS, Shigeru Yamada, MD, PhD, Tadashi Kamada, MD, PhD, Hirohiko Tsujii, MD, PhD, Naoya Kato, MD, PhD, Masaru Miyazaki, MD, PhD, Shigeki Arii, Masaaki Ebara, Junji Furuse, Kiyoshi Ohara, Takuji Okusaka, Takehito Otsubo, Masayuki Otsuka, Fumihoko Kanai, Fukuo Kondo, Akiko Saito, Yoshiaki Shimizu, Kenichi Takayasu, Ikuo Udagawa, Hiroshi Yamamoto, Junji Yamamoto, Masakazu Yamamoto, Osamu Yokosuka, Hiroyuki Yoshidome
Publikováno v:
Advances in Radiation Oncology, Vol 5, Iss 2, Pp 196-203 (2020)
Purpose: Carbon ion beams have several physical and biological advantages compared with conventional radiation for cancer therapy. The objective of this study is to evaluate the safety and effectiveness of 2-fraction carbon ion radiation therapy (CIR
Externí odkaz:
https://doaj.org/article/ab17cbd4745440de837ee7b8a05c953f