Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Masayoshi Miyagawa"'
Autor:
Yoshiyuki Taoda, Toshiyuki Akiyama, Tomokazu Yoshinaga, Masayoshi Miyagawa, Kenji Tomita, Kenji Takaya, Kazunari Hattori, Shinya Shano, Takao Shishido, Akihiko Sato, Kazuya Yasuo, Makoto Kawai, Ryu Yoshida, Chika Takahashi-Kageyama
Publikováno v:
Journal of Medicinal Chemistry. 62:8101-8114
The medicinal chemistry and structure-activity relationships (SAR) for a novel series of carbamoyl pyridone bicycle (CAB) compounds as influenza Cap-dependent endonuclease (CEN) inhibitors are disclosed. Substituent effects were evaluated at the C (N
Autor:
Yoshiyuki Taoda, Takeshi Noshi, Ryu Yoshida, Makoto Kawai, Kenji Tomita, Yasushi Hasegawa, Masayoshi Miyagawa, Toshiyuki Akiyama, Takao Shishido
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(22)
This work describes a set of discovery research studies of an influenza cap-dependent endonuclease (CEN) inhibitor with a carbamoyl pyridone bicycle (CAB) scaffold. Using influenza CEN inhibitory activity, antiviral activity and pharmacokinetic (PK)
Publikováno v:
Bioscience, biotechnology, and biochemistry. 56(6)
To investigate the usefulness of ornithine and urea as freshness indices for marine invertebrates, the muscle tissue from freshly caught samples was stored in ice for 15 days and the free amino acid concentration was measured. The total amount of fre
Autor:
Takao Shishido, Minako Mikamiyama-Iwata, Yoshiyuki Taoda, Tomokazu Yoshinaga, Ryu Yoshida, Naoko Kurihara, Naoyuki Suzuki, Kenji Morimoto, Noriyuki Kurose, Masayoshi Miyagawa, Hidenori Mikamiyama, Makoto Kawai, Kazunari Hattori, Kenji Tomita, Chika Takahashi-Kageyama, Toshiyuki Akiyama, Kenji Matsuo, Kenji Takaya, Akihiko Sato
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(19)
We report the discovery of a novel series of influenza Cap-dependent EndoNuclease (CEN) inhibitors based on the 4-pyridone-carboxylic acid (PYXA) scaffold, which were found from our chelate library. Our SAR research revealed the lipophilic domain to
Autor:
Yousuke Takaoka, Masayoshi Miyagawa, Itaru Hamachi, Hangxiang Wang, Tomonori Tamura, Shinya Tsukiji
Publikováno v:
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 131(25):9046-9054
Semisynthetic fluorescent biosensors consisting of a protein framework and a synthetic fluorophore are powerful analytical tools for specific detection of biologically relevant molecules. We report herein a novel method that allows for the constructi
Autor:
Yoichiro Koshi, Tomohisa Ogawa, Masayoshi Miyagawa, Shinya Tsukiji, Itaru Hamachi, Eiji Nakata
Publikováno v:
Journal of the American Chemical Society. 130:245-251
Because sugar-binding proteins, so-called lectins, play important roles in many biological phenomena, the lectin-selective labeling should be useful for investigating biological processes involving lectins as well as providing molecular tools for ana
Publikováno v:
NATURE CHEMICAL BIOLOGY. 5(5):341-343
Here we describe a method for the site-selective attachment of synthetic molecules into specific 'endogenous' proteins in vivo using ligand-directed tosyl (LDT) chemistry. This approach was applied not only for chemically labeling proteins in living
Autor:
Keigo Mizusawa, Masayoshi Miyagawa, Itaru Hamachi, Yousuke Takaoka, Yoshiyuki Ishida, Shinya Tsukiji
Publikováno v:
Journal of the American Chemical Society. 132(21)
"Switchable" fluorescent probes, which induce changes in the fluorescence properties (e.g., intensity and/or wavelength) only at the intended target protein, are particularly useful for selective protein detection or imaging. However, the strategy fo
Autor:
Yousuke Takaoka, Itaru Hamachi, Yoichiro Koshi, Shinya Tsukiji, Masayoshi Miyagawa, Haruto Wakabayashi
Publikováno v:
Chemistry, an Asian journal. 3(7)
A new chemical method to site-specifically modify natural proteins without the need for genetic manipulation is described. Our strategy involves the affinity-labeling-based attachment of a unique reactive handle at the surface of the target protein,
Autor:
Masayoshi Miyagawa, Yoshihiro Tabuchi, Kyouichiro Yamane, Hisako Matsuda, Shugo Watabe, Kanehisa Hashimoto, Ryoichi Katakai, Yuzuru Otsuka
Publikováno v:
Agricultural and Biological Chemistry. 54:359-364