Zobrazeno 1 - 10
of 381
pro vyhledávání: '"Masayoshi Mishina"'
Autor:
Dae Hee Han, Ilgang Hong, Ja Eun Choi, Pojeong Park, Jun-Yeong Baek, HyoJin Park, Soichiro Ide, Masayoshi Mishina, Kazutaka Ikeda, Bong-Kiun Kaang
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-5 (2021)
Abstract Ketamine, a non-competitive antagonist of the N-methyl-d-aspartate receptor (NMDAR), generates a rapidly-acting antidepressant effect. It exerts psychomimetic effects, yet demands a further investigation of its mechanism. Previous research s
Externí odkaz:
https://doaj.org/article/13ad37c1b36147509b95aace83a1495e
Autor:
Tomoyuki Yoshida, Atsushi Yamagata, Ayako Imai, Juhyon Kim, Hironori Izumi, Shogo Nakashima, Tomoko Shiroshima, Asami Maeda, Shiho Iwasawa-Okamoto, Kenji Azechi, Fumina Osaka, Takashi Saitoh, Katsumi Maenaka, Takashi Shimada, Yuko Fukata, Masaki Fukata, Jumpei Matsumoto, Hisao Nishijo, Keizo Takao, Shinji Tanaka, Shigeo Okabe, Katsuhiko Tabuchi, Takeshi Uemura, Masayoshi Mishina, Hisashi Mori, Shuya Fukai
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Mutations of Neuroligin 3 (NLGN3) have been associated with autism spectrum disorder (ASD). Here, the authors identify a previously undescribed interaction between NLGN3 and a splice variant of protein tyrosine phosphatase δ (PTP δ) and its role in
Externí odkaz:
https://doaj.org/article/088ec8c07114426fb988df9303a95e47
Autor:
Takeshi Uemura, Emi Suzuki-Kouyama, Shiori Kawase, Taiga Kurihara, Misato Yasumura, Tomoyuki Yoshida, Shuya Fukai, Maya Yamazaki, Peng Fei, Manabu Abe, Masahiko Watanabe, Kenji Sakimura, Masayoshi Mishina, Katsuhiko Tabuchi
Publikováno v:
Cell Reports, Vol 39, Iss 1, Pp 110624- (2022)
Summary: Neurexins (NRXNs) are key presynaptic cell adhesion molecules that regulate synapse formation and function via trans-synaptic interaction with postsynaptic ligands. Here, we generate cerebellar granule cell (CGC)-specific Nrxn triple-knockou
Externí odkaz:
https://doaj.org/article/0a9c724aca2349bf9282e563b22cbc56
Autor:
Masayuki Itoh, Hiroyuki Okuno, Daisuke Yamada, Mariko Yamashita, Manabu Abe, Rie Natsume, Toshie Kaizuka, Kenji Sakimura, Mikio Hoshino, Masayoshi Mishina, Keiji Wada, Masayuki Sekiguchi, Takashi Hayashi
Publikováno v:
Neuropsychopharmacology Reports, Vol 39, Iss 1, Pp 61-66 (2019)
Abstract Background AMPA receptors predominantly mediate fast excitatory synaptic transmission in the mammalian brain. Post‐translational protein S‐palmitoylation of AMPA receptor GluA subunits at their C‐termini reversibly controls the recepto
Externí odkaz:
https://doaj.org/article/ecf081570cff4b95bca36a99c2b6fef0
Publikováno v:
Journal of Pharmacological Sciences, Vol 135, Iss 3, Pp 138-140 (2017)
We investigated the rapid and sustained antidepressant effects of enantiomers of ketamine in N-methyl-d-aspartate (NMDA) receptor GluN2D subunit knockout (GluN2D-KO) mice. Intraperitoneal administration of ketamine or its enantiomers 10 min before th
Externí odkaz:
https://doaj.org/article/0fc0a8cb963c44c3938dbe348a6d5fc7
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
N-methyl-D-aspartate receptors (NMDARs) are ubiquitously expressed in the mammalian brain and are essential for neuronal development, survival and plasticity. GluN2 subunit composition has a profound effect on the properties of NMDARs. In substantia
Externí odkaz:
https://doaj.org/article/030261b3d647443aa021c32ed04086a9
Autor:
Kelly Kawabata Galbraith, Kazuto Fujishima, Hiroaki Mizuno, Sung-Jin Lee, Takeshi Uemura, Kenji Sakimura, Masayoshi Mishina, Naoki Watanabe, Mineko Kengaku
Publikováno v:
Cell Reports, Vol 24, Iss 1, Pp 95-106.e9 (2018)
Summary: Dendritic filopodia of developing neurons function as environmental sensors, regulating the spatial organization of dendrites and proper targeting to presynaptic partners. Dendritic filopodia morphology is determined by the balance of F-acti
Externí odkaz:
https://doaj.org/article/b2675c379c9e4c9e91fd7e58cf8a0eda
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66254 (2013)
Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1) is associated with X-linked mental retardation and autism spectrum disorder. We found that IL1RAPL1 regulates synapse formation of cortical neurons. To investigate how IL1RAPL1 controls synap
Externí odkaz:
https://doaj.org/article/b9ab222c7db64fd6a965e7d165a24fe0
Autor:
Megumi Kaneko, Kazuhiko Yamaguchi, Mototsugu Eiraku, Motohiko Sato, Norio Takata, Yoshimoto Kiyohara, Masayoshi Mishina, Hajime Hirase, Tsutomu Hashikawa, Mineko Kengaku
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20108 (2011)
Dendrite arborization patterns are critical determinants of neuronal connectivity and integration. Planar and highly branched dendrites of the cerebellar Purkinje cell receive specific topographical projections from two major afferent pathways; a sin
Externí odkaz:
https://doaj.org/article/5e194df6f02c4795b56c97a220fbe38f
Autor:
Yoko Hagino, Shinya Kasai, Wenhua Han, Hideko Yamamoto, Toshitaka Nabeshima, Masayoshi Mishina, Kazutaka Ikeda
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13722 (2010)
Phencyclidine (PCP), a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, increases locomotor activity in rodents and causes schizophrenia-like symptoms in humans. Although activation of the dopamine (DA) pathway is hypothesized to media
Externí odkaz:
https://doaj.org/article/70d0c863d5b44631b48e809b6e8683c4