Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Masayoshi Ishizawa"'
Autor:
Hiroyuki Morita, Yoshiyuki Natsume, Yoshinori Kanoh, Masayoshi Ishizawa, Yoshihiro Uno, Kazuo Kajita, Keigo Yasuda, Atsushi Miura, Yasunori Kawai, Tatsuo Ishizuka
Publikováno v:
Endocrine Research. 30:287-299
In vitro phosphorylation of 180-kDa protein, obtained by immunoprecipitation of adipocyte homogenate with anti-IRS-1 antibody was increased with the addition of conventional PKC in the presence of Ca2+, phosphatidylserine (PS) and diolein (DL). Human
Autor:
Yoshiyuki Natsume, Atsushi Miura, Yasunori Kawai, Kazuo Kajita, Tomoatsu Mune, Yoshinori Kanoh, Tatsuo Ishizuka, Masayoshi Ishizawa, Keigo Yasuda
Publikováno v:
Endocrinology. 144:253-259
Dehydroepiandrosterone (DHEA) is expected to have a weight-reducing effect. In this study, we evaluated the effect of DHEA on genetically obese Otsuka Long Evans Fatty rats (OLETF) compared with Long-Evans Tokushima rats (LETO) as control. Feeding wi
Autor:
Yoshiyuki Natsume, Masayoshi Ishizawa, Yoritsuna Yamamoto, Yasunori Kawai, Keigo Yasuda, Atsushi Miura, Kazuo Kajita, Hiroya Sakuma, Tatsuo Ishizuka, Yoshinori Kanoh
Publikováno v:
Metabolism. 52:19-24
Ceramide has been confirmed to be a signal mediator of apoptosis that is induced by tumor necrosis factor-alpha (TNF-alpha). It has also been reported that ceramide may induce insulin resistance as well as TNF-alpha. We investigated the effect of cer
Autor:
Yoshiyuki Natsume, Atsushi Miura, Tatsuo Ishizuka, Yoshihiro Uno, Hiroyuki Morita, Masayoshi Ishizawa, Keigo Yasuda, Yasunori Kawai, Kazuo Kajita
Publikováno v:
IUBMB Life (International Union of Biochemistry and Molecular Biology: Life). 54:365-370
Pretreatment with glucocorticoids for 60 min depressed insulin-stimulated uptake of 2-[3H] deoxyglucose (2-DOG), an effect that neither cycloheximide, an inhibitor of protein synthesis, nor RU38486, a glucocorticoid receptor antagonist, could restore
Autor:
Yoshihiro Uno, Mika Kimura, Keigo Yasuda, Masayoshi Ishizawa, Yasunori Kawai, Atsushi Miura, Hiroyuki Morita, Kazuo Kajita, Yannan Huang, Tatsuo Ishizuka
Publikováno v:
IUBMB Life (International Union of Biochemistry and Molecular Biology: Life). 51:299-304
Insulin stimulates glucose uptake in association with phosphatidylinositol (PI) 3-kinase activation mechanisms in rat adipocytes. Insulin stimulated glucose uptake to 6.5-fold, and 12-o-tetradecanoyl phorbol 13-acetate (TPA) also stimulated glucose u
Autor:
Keigo Yasuda, Tatsuo Ishizuka, Mika Kimura, Yoshinori Kanoh, Yoshihiro Uno, Hiroyuki Morita, Atsushi Miura, Masayoshi Ishizawa, Satomi Itaya
Publikováno v:
Platelets. 12:138-143
It has been reported that platelet aggregation in diabetic patients with microangiopathy is increased compared with healthy subjects. Chronic hyperglycemia is known to cause an increase in diacylglycerol level in various tissues. We examine whether p
Autor:
Keigo Yasuda, Mika Kimura, Yoshinori Kanoh, Kazuo Kajita, Satomi Itaya, Atsushi Miura, Masayoshi Ishizawa, Tatsuo Ishizuka
Publikováno v:
IUBMB Life. 46:739-745
This study examined the effect of glucose and 12-O-tetradecanoylphorbol-13-acetate (TPA) on insulin secretion in isolated human insulinoma cells. In addition, we analyzed conventional PKC alpha and beta activation in the membrane fractions, respectiv
Autor:
Chiyo Sugiyama, Kazuo Kajita, Takahide Ikeda, Tatsuo Ishizuka, Yoshihiro Uno, Masami Matsumoto, Masayoshi Ishizawa, Kenji Matsubara, Hiroyuki Morita
Publikováno v:
Platelets. 18(2)
To clarify the relationship between serum leptin concentration and platelet aggregation mechanism, we investigated serum leptin concentration and agonist-induced platelet aggregation in eight obese subjects and eight non-obese and non-diabetic contro
Autor:
Toshiroh Shibata, K. Yamada, Keigo Yasuda, Kazuo Kajita, Yoshinori Kanoh, Mika Kimura, Hiroaki Wada, Satomi Itaya, Tatsuo Ishizuka, Atsushi Miura, Masayoshi Ishizawa
Publikováno v:
Platelets. 10(1)
We previously reported the effects of diet, sulphonylureas or insulin on thrombin-induced platelet aggregation, phosphoinositide metabolism and protein phosphorylation in non-insulin-dependent diabetes mellitus (NIDDM) patients. To clarify the mechan
Autor:
Hiroshi Sarui, Tomoatsu Mune, Minoru Yasujima, Keigo Yasuda, Yoshinori Kanoh, Noriyuki Takeda, Masayoshi Ishizawa, Shoji Tsutaya, Mayumi Enya, Jun Takeda, Mayumi Yamamoto
Publikováno v:
Internal medicine (Tokyo, Japan). 43(5)
A 69-year-old woman was referred to our department for evaluation of hypokalemia, which had been treated by oral potassium for more than ten years. She complained of headache, knee joint pain, sleeplessness and paresthesia in extremities and, most pr