Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Masayoshi Fujimaki"'
Publikováno v:
Investigative Radiology. 42:643-651
The objective of this study was to elucidate the mechanism of hepatic parenchyma-specific contrast of Sonazoid (microbubble contrast agent) using microscopic techniques.Sonazoid was intravenously injected into rats to investigate the microbubble dyna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c06427aed2c554a42d60e2b1ddd3b0eb
https://doi.org/10.1097/rli.0b013e31805f2682
https://doi.org/10.1097/rli.0b013e31805f2682
Publikováno v:
Biological and Pharmaceutical Bulletin. 28:972-977
In order to investigate improvement of hepatic tumor detectability by Sonazoid with phase inversion imaging, the contrast effects on the liver of metastatic carcinoma-model rabbits were evaluated by videodensitometry and visual assessment. Correlatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58c83d2afcc9a089c56bfd235bd4daec
https://doi.org/10.1248/bpb.28.972
https://doi.org/10.1248/bpb.28.972
Autor:
Masayoshi Fujimaki, Rira Watanabe, Chun-Jen Chen, Manabu Matsumura, Masanao Ishihara, Yuki Kaneda
Publikováno v:
Biological & Pharmaceutical Bulletin. 26:1272-1277
The liver contrast effects of Sonazoid in two ultrasonographic imaging modes, gray-scale conventional and harmonic, were examined as a time-related study in normal rabbits, and evaluated quantitatively and visually with tumor-model rabbits to estimat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09f118a3d57cfe5ebde545215082e3d6
https://doi.org/10.1248/bpb.26.1272
https://doi.org/10.1248/bpb.26.1272
Publikováno v:
Chemical and Pharmaceutical Bulletin. 47:727-731
Physicochemical properties of a newly developed oral negative contrast agent, oral magnetic particles (OMP, Ferristene), for abdominal magnetic resonance (MR) imaging were evaluated in a preformulation study. X-Ray diffiraction pattern and transmissi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5dfecaea3f362dc4ba4d5e14ea4bef51
https://doi.org/10.1248/cpb.47.727
https://doi.org/10.1248/cpb.47.727
Publikováno v:
Journal of Pharmaceutical Sciences. 79:568-572
Carvedilol is a new beta-blocking agent with vasodilating activities, which is a racemic mixture of R(+)- and S(-)-enantiomers. Since the two enantiomers differ in pharmacological properties, it is necessary to individually measure their plasma conce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2023fb48455f4c8d9635db88b3d211a4
https://doi.org/10.1002/jps.2600790704
https://doi.org/10.1002/jps.2600790704
Publikováno v:
The Journal of pharmacy and pharmacology. 53(6)
An in-vitro study was conducted to investigate the metabolism of nefiracetam in human liver microsomes and to identify the enzymes responsible for the metabolism. Nefiracetam was hydroxylated by human liver microsomes to 5-hydroxynefiracetam (5-OHN).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::478df7d5bbd20f8f7c623150f547144d
https://pubmed.ncbi.nlm.nih.gov/11428655
https://pubmed.ncbi.nlm.nih.gov/11428655
Autor:
Masayoshi Fujimaki
Publikováno v:
Chirality. 4(3)
After intravenous bolus injection of rac-carvedilol at 2 mg/kg to the rat, the (+)-(R)- and (—)-(S)-enantiomer levels in the blood and tissues (liver, kidney, heart, muscle, spleen, and aorta) were measured by stereospecific HPLC assay. As compared
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1d40202c23296ea2bdc5c78e0f55511
https://pubmed.ncbi.nlm.nih.gov/1586585
https://pubmed.ncbi.nlm.nih.gov/1586585
Autor:
Hideo Hakusui, Masayoshi Fujimaki
Publikováno v:
Drug Metabolism and Pharmacokinetics. 4:667-671
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::473824a766a97909fcd47ad91ee4a3bb
https://doi.org/10.2133/dmpk.4.667
https://doi.org/10.2133/dmpk.4.667
Publikováno v:
Drug Metabolism and Pharmacokinetics. 4:673-677
Transfer of the radioactivity into the milk was studied after a single oral administration of 14C-carvedilol at a dose of 10 mg/kg to lactating rats. The concentrations of radioactivity in the milk were higher than that in the plasma throughout the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eca4d27433dd3b742ed2793be5d32a7e
https://doi.org/10.2133/dmpk.4.673
https://doi.org/10.2133/dmpk.4.673
Autor:
Hideo Hakusui, Masayoshi Fujimaki, Yoshio Esumi, Matsuo Takaichi, Naoko Saitou, Takako Honda, Takayuki Miyake, Takashi Yokota
Publikováno v:
Drug Metabolism and Pharmacokinetics. 4:651-665
Pharmacokinetic studies on blood level, tissue distribution and excretion of carvedilol, a new β-blocking agent, were performed in rats during and after the consecutive oral administration of 14C-carvedilol at a daily dose of 10mg/kg for 21 days.1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44d042e4f4dadd5b2006a6dd8f6ade9a
https://doi.org/10.2133/dmpk.4.651
https://doi.org/10.2133/dmpk.4.651