Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Masayo Higashiyama"'
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 43:1335-1342
Ion pair formation between timolol and sorbic acid was investigated using NMR spectroscopy in order to clarify their interactions within ophthalmic preparation. 13 C and 1 H NMR spectra of timolol, sorbic acid, and a mixture of the two were obtained,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bec225d439504822e4d2c5f513f2fd58
https://doi.org/10.1016/j.jpba.2006.10.043
https://doi.org/10.1016/j.jpba.2006.10.043
Publikováno v:
Drug Development and Industrial Pharmacy. 33:805-811
The cornea is a solid barrier against drug permeation. We searched the critical barrier of corneal drug permeation using a hydrophobic drug, dexamethasone (DM), and a hydrophilic drug, lomefloxacin hydrochloride (LFLX). The activation energies for pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c091698008e68a85c26cd20cf62861a
https://doi.org/10.1080/03639040701377995
https://doi.org/10.1080/03639040701377995
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 22:333-339
Ocular bioavailability after instillation of carteolol was investigated by ion pair formation, taking into consideration a balance between lipophilicity and water solubility. The octanol/ water partition coefficient (PC(O/W)) and the aqueous humor co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::014137b6fe981550f23876447aa1ddd1
https://doi.org/10.1089/jop.2006.22.333
https://doi.org/10.1089/jop.2006.22.333
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 36:309-316
Validation of an analytical method for impurities and degradation products in an active pharmaceutical ingredient is important to assessment of quality and safety in a new pharmaceutical product. In the present study, a high-performance liquid chroma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c5971b013a06ddfbac2dbe87ccc24ea
https://doi.org/10.1016/j.jpba.2004.06.006
https://doi.org/10.1016/j.jpba.2004.06.006
Publikováno v:
International Journal of Pharmaceutics. 272:91-98
The ocular bioavailability of timolol increased in sorbic acid solution due to ion pair formation. Its octanol/water partition coefficient also increased, suggesting the formation of a more lipophilic complex. The concentration of timolol in rabbit a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40699e9ed40dd21cfcbbc1560808de30
https://doi.org/10.1016/j.ijpharm.2003.11.035
https://doi.org/10.1016/j.ijpharm.2003.11.035
Autor:
Takayuki Shioiri, Akira Ando, Moriyasu Masui, Toshio Miura, Toshiaki Tatematsu, Akemi Bohsako, Masayo Higashiyama, Chiharu Asakura
Publikováno v:
ACS Symposium Series ISBN: 9780841234918
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8bd1b7b5cfcbd972b03c99e25d903ee
https://doi.org/10.1021/bk-1997-0659.ch011
https://doi.org/10.1021/bk-1997-0659.ch011
Autor:
MARC E. HALPERN, Charles M. Starks, Charles L. Liotta, Joachim Berkner, James Wright, Barbara Fair, M. Makosza, S. S. Yufit, G. V. Kryshtal, Irina A. Esikova, F. S. Sirovski, Theresa Stines Nahreini, Martin J. O'Donnell, Eckehard Volker Dehmlow, Aiqiao Mi, Daniel F. Shullenberger, Shengde Wu, Takayuki Shioiri, Akira Ando, Moriyasu Masui, Toshio Miura, Toshiaki Tatematsu, Akemi Bohsako, Masayo Higashiyama, Chiharu Asakura, Yoel Sasson, Noam Mushkin, Eli Abu, Samuel Negussie, Salman Dermeik, Ami Zoran, R. Roy, F. D. Tropper, S. Cao, J. M. Kim, Enrique Diez-Barra, Antonio de la Hoz, Sonia Merino, Prado Sánchez-Verdú, Toshio Takido, Takayoshi Fujihira, Manabu Seno, Kunio Itabashi, Yaozhong Jiang, Yuliang Wang, Runhua Deng, Tadatomi Nishikubo, Shigeo Nakamura, Chonghui Wang, Noritaka Ohtani, Yukihiko Inoue, Jun Mukudai, Tsuyoshi Yamashita, N. N. Dutta, A. C. Ghosh, R. K. Mathur, T. Balakrishnan, J. Paul Jayachandran, Mikio Ouchi, Kenji Mishima, Reizo Dohno, Tadao Hakushi