Zobrazeno 1 - 10
of 882
pro vyhledávání: '"Masaya Tohyama"'
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Major depressive disorder (MDD) is a multifactorial disease affected by several environmental factors. Although several potential onset hypotheses have been identified, the molecular mechanisms underlying the pathogenesis of this disorder remain uncl
Externí odkaz:
https://doaj.org/article/3c8fbd7a7ccb44268426eedc530c43c5
Autor:
Shinsuke Matsuzaki, Toru Hiratsuka, Manabu Taniguchi, Kenta Shingaki, Tateki Kubo, Koichiro Kiya, Toshihiro Fujiwara, Shigeyuki Kanazawa, Ryutaro Kanematsu, Tameyasu Maeda, Hironori Takamura, Kohe Yamada, Ko Miyoshi, Ko Hosokawa, Masaya Tohyama, Taiichi Katayama
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123578 (2015)
Recently, accumulating reports have suggested the importance of endoplasmic reticulum (ER) stress signaling in the differentiation of several tissues and cells, including myoblasts and osteoblasts. Secretory cells are easily subjected to ER stress du
Externí odkaz:
https://doaj.org/article/30d68b8b48eb46ccad33352280f11236
Autor:
Yoshio Bando, Taiichi Katayama, Manabu Taniguchi, Tomohiko Ishibashi, Noriyuki Matsuo, Satoshi Ogawa, Masaya Tohyama
Publikováno v:
Neurobiology of Disease, Vol 18, Iss 1, Pp 143-151 (2005)
Parkinson's disease is characterized by selective loss of dopaminergic neurons in the substantia nigra. However, its associated cell death mechanism remains unknown. 1-Methyl-4-phenil-pyridinium (MPP+) and 6-hydroxydopamine (6-OHDA) cause dopaminergi
Externí odkaz:
https://doaj.org/article/0d2bdb82604c493e85e683d8774b7b59
Autor:
Takashi Fujiwara, Shigeyuki Kanazawa, Ryoko Ichibori, Tomoko Tanigawa, Takuya Magome, Kenta Shingaki, Shingo Miyata, Masaya Tohyama, Ko Hosokawa
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92168 (2014)
L-arginine is considered a conditionally essential amino acid and has been shown to enhance wound healing. However, the molecular mechanisms through which arginine stimulates cutaneous wound repair remain unknown. Here, we evaluated the effects of ar
Externí odkaz:
https://doaj.org/article/1a1e668aa3f340e8b7da517bed4ccecf
Autor:
Tsuyoshi Hattori, Shoko Shimizu, Yoshihisa Koyama, Hisayo Emoto, Yuji Matsumoto, Natsuko Kumamoto, Kohei Yamada, Hironori Takamura, Shinsuke Matsuzaki, Taiichi Katayama, Masaya Tohyama, Akira Ito
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88506 (2014)
Disrupted-in-schizophrenia 1 (DISC1) is a gene disrupted by a translocation, t(1;11) (q42.1;q14.3), that segregates with major psychiatric disorders, including schizophrenia, recurrent major depression and bipolar affective disorder, in a Scottish fa
Externí odkaz:
https://doaj.org/article/8765681b92ae450e9c43867f6ae9b463
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69732 (2013)
The Golgi apparatus is important for the transport of secretory cargo. Glycosylation is a major post-translational event. Recognition of O-glycans on proteins is necessary for glycoprotein trafficking. In this study, specific inhibition of O-glycosyl
Externí odkaz:
https://doaj.org/article/cc96c1ff5f8e487ab5ffdd18d98e18fe
Autor:
Hironori Takamura, Yoshihisa Koyama, Shinsuke Matsuzaki, Kohei Yamada, Tsuyoshi Hattori, Shingo Miyata, Kana Takemoto, Masaya Tohyama, Taiichi Katayama
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51912 (2012)
Mitochondria are dynamic organelles that change in response to extracellular stimuli. These changes are essential for normal mitochondrial/cellular function and are controlled by a tight balance between two antagonistic pathways that promote fusion a
Externí odkaz:
https://doaj.org/article/ccc68fcbde504d398ef516deee62dda8
Autor:
Shingo Miyata, Yoshihisa Koyama, Kana Takemoto, Keiko Yoshikawa, Toshiko Ishikawa, Manabu Taniguchi, Kiyoshi Inoue, Miwa Aoki, Osamu Hori, Taiichi Katayama, Masaya Tohyama
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19859 (2011)
Repeated stressful events are known to be associated with onset of depression. Further, stress activates the hypothalamic-pituitary-adrenocortical (HPA) system by elevating plasma cortisol levels. However, little is known about the related downstream
Externí odkaz:
https://doaj.org/article/726754691eca4d388046958fb3e0950a
Autor:
Naomi Nihonmatsu-Kikuchi, Ryota Hashimoto, Satoko Hattori, Shinsuke Matsuzaki, Takiko Shinozaki, Haruka Miura, Shigeru Ohota, Masaya Tohyama, Masatoshi Takeda, Yoshitaka Tatebayashi
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e15886 (2011)
Genetic variations in the gene encoding dysbindin has consistently been associated with schizophrenia and bipolar disorder, although little is known about the neural functions carried out by dysbindin. To gain some insight into this area, we took adv
Externí odkaz:
https://doaj.org/article/a0d18ac8b3394b41aaeb57ccdcf16755
Autor:
Toru Hiratsuka, Shinsuke Matsuzaki, Shingo Miyata, Mitsuhiro Kinoshita, Kazuaki Kakehi, Shinji Nishida, Taiichi Katayama, Masaya Tohyama
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13280 (2010)
BackgroundRecently, several studies have reported Yokukansan (Tsumura TJ-54), a traditional Japanese medicine, as a potential new drug for the treatment of Alzheimer's disease (AD). Endoplasmic reticulum (ER) stress is known to play an important role
Externí odkaz:
https://doaj.org/article/9199ae2f7a49460da6d55aded088de7d