Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Masaya Denda"'
Autor:
Kazuto Nakae, Sho Masui, Atsushi Yonezawa, Motomu Hashimoto, Ryu Watanabe, Koichi Murata, Kosaku Murakami, Masao Tanaka, Hiromu Ito, Kotoko Yokoyama, Noriko Iwamoto, Takashi Shimada, Miyuki Nakamura, Masaya Denda, Kotaro Itohara, Shunsaku Nakagawa, Yasuaki Ikemi, Satoshi Imai, Takayuki Nakagawa, Makoto Hayakari, Kazuo Matsubara
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0258601 (2021)
Infliximab (IFX) therapy has considerably improved the treatment of rheumatoid arthritis (RA). However, some patients still do not respond adequately to IFX therapy, or the efficacy of the treatment diminishes over time. Although previous studies hav
Externí odkaz:
https://doaj.org/article/92632b552d964cf2aa8dc1bb174b66c4
Autor:
Dr. Daishiro Kobayashi, Dr. Masaya Denda, Junya Hayashi, Kota Hidaka, Yutaka Kohmura, Dr. Takaaki Tsunematsu, Dr. Kohei Nishino, Dr. Harunori Yoshikawa, Dr. Kento Ohkawachi, Dr. Kiyomi Nigorikawa, Dr. Tetsuro Yoshimaru, Prof. Naozumi Ishimaru, Prof. Wataru Nomura, Prof. Toyomasa Katagiri, Prof. Hidetaka Kosako, Prof. Akira Otaka
Publikováno v:
ChemistryEurope, Vol 2, Iss 3-4, Pp n/a-n/a (2024)
Abstract A method was developed that enables the magnesium chloride (MgCl2)‐activated S‐acetamidomethyl cysteine sulfoxide (Cys(Acm)(O)) to induce the sp2(C−H) sulfenylation of the indole of Trp residues. The reaction operates under mild acidic
Externí odkaz:
https://doaj.org/article/222723dbb8234764ba71bc9a59b8809f
Autor:
Daishiro Kobayashi, Eisuke Kuraoka, Junya Hayashi, Takuma Yasuda, Yutaka Kohmura, Masaya Denda, Norio Harada, Nobuya Inagaki, Akira Otaka
Publikováno v:
ACS Medicinal Chemistry Letters. 13(7):1125-1130
Lipidation of peptides is a promising means of modification that can improve the therapeutic character of biologically active peptides. Here a novel lipidation protocol for peptides is described. The C−H sulfenylation of indole in peptides using S-
Autor:
Masaya, Denda, Akira, Otaka
Publikováno v:
Chemical and Pharmaceutical Bulletin. 70:316-323
The growing interest in artificial proteins modified by synthetic functional units has fueled the demand for their facile preparation. Native chemical ligation (NCL) enables the chemoselective condensation of peptide thioesters with a cysteine-instal
Autor:
Kento Ohkawachi, Kaito Anzaki, Daishiro Kobayashi, Ryuji Kyan, Takuma Yasuda, Masaya Denda, Norio Harada, Akira Shigenaga, Nobuya Inagaki, Akira Otaka
Publikováno v:
Chemistry – A European Journal. 29
Autor:
Kento Ohkawachi, Kaito Anzaki, Daishiro Kobayashi, Ryuji Kyan, Takuma Yasuda, Masaya Denda, Norio Harada, Akira Shigenaga, Nobuya Inagaki, Akira Otaka
Publikováno v:
Chemistry – A European Journal. 29
A tyrosine (Tyr)- or tryptophan (Trp)-selective metal-free C−H sulfenylation reaction using an acid-activated Sacetamidomethyl cysteine (Cys) sulfoxide, Cys(Acm)(O), has been achieved. The dually protonated intermediate produced from the Cys(Acm)(O
Autor:
Eisuke Kuraoka, Toshimichi Fujiwara, Masaya Denda, Daishiro Kobayashi, Akira Otaka, Yutaka Kohmura, Toshihiko Sugiki
Publikováno v:
Chemistry – A European Journal. 27:14092-14099
Covalent linking of side chains provides a method to produce cyclic or stapling peptides that are important in developing peptide-based drugs. A variety of crosslinking formats contribute to fixing the active conformer and prolonging its biological a
Autor:
Keiichiro Okuhira, Masahiro Ueda, Sayuki Arii, Chiaki Komiya, Kohshi Kusumoto, Masaya Denda, Akira Otaka, Akira Shigenaga
Publikováno v:
Chemical and Pharmaceutical Bulletin. 68:1226-1232
Proteins incorporating artificial moieties such as fluorophores and drugs have enjoyed increasing use in chemical biology and drug development research. Preparation of such artificial protein derivatives has relied mainly on native chemical ligation
Autor:
Daiki Sato, Masaya Denda, Honoka Tsunematsu, Naonobu Tanaka, Isamu Konishi, Chiaki Komiya, Akira Shigenaga, Akira Otaka
Publikováno v:
Chemical communications (Cambridge, England). 58(17)
Intramolecular S-acylation of a thiol-installed threonine with a thioester unit, followed by S–O acyl transfer and subsequent desulphurisation, allows the synthesis of lactone peptides. A protocol has been developed enabling the cyclisation of a li
Autor:
Masaya Denda, Kenzo Yamatsugu, Akira Shigenaga, Daishiro Kobayashi, Motomu Kanai, Akira Otaka, Kento Ohkawachi, Kyohei Morimoto
Publikováno v:
Organic Letters. 22:5289-5293
Sulfanylmethyl-installed dimethylaminopyridine, 2-sulfanylmethyl-4-dimthylaminopyridine (SMDMAP) (2), has an acidic thiol group comparable to that in aryl thiols due to the formation of a zwitterion consisting of a thiolate anion and a pyridinium cat