Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Masaya Araki"'
Autor:
Ye Cao, Masaya Araki, Yoshimi Nakagawa, Luisa Deisen, Annemarie Lundsgaard, Josephine M. Kanta, Stephanie Holm, Kornelia Johann, Jens Christian Brings Jacobsen, Markus Jähnert, Annette Schürmann, Bente Kiens, Christoffer Clemmensen, Hitoshi Shimano, Andreas M. Fritzen, Maximilian Kleinert
Publikováno v:
Molecular Metabolism, Vol 87, Iss , Pp 101991- (2024)
Objective: Dietary medium-chain fatty acids (MCFAs), characterized by chain lengths of 8–12 carbon atoms, have been proposed to have beneficial effects on glucose and lipid metabolism, yet the underlying mechanisms remain elusive. We hypothesized t
Externí odkaz:
https://doaj.org/article/a73423385e39458e84871af2e20ee693
Autor:
Yumiko Oishi, Hiroyuki Koike, Naoki Kumagami, Yoshimi Nakagawa, Masaya Araki, Yoshitaka Taketomi, Yoshimi Miki, Shigeru Matsuda, Hyeree Kim, Takashi Matsuzaka, Hitoshi Ozawa, Hitoshi Shimano, Makoto Murakami, Ichiro Manabe
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/83932a201d8b47b5a1708bb18e95e23b
Autor:
Yumiko Oishi, Hiroyuki Koike, Naoki Kumagami, Yoshimi Nakagawa, Masaya Araki, Yoshitaka Taketomi, Yoshimi Miki, Shigeru Matsuda, Hyeree Kim, Takashi Matsuzaka, Hitoshi Ozawa, Hitoshi Shimano, Makoto Murakami, Ichiro Manabe
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Macrophages are essential for the proper inflammatory and reparative processes that lead to regeneration of skeletal muscle after injury. Recent studies have demonstrated close links between the function of activated macrophages and their cellular me
Externí odkaz:
https://doaj.org/article/088ae18d365b47d4b949f461006d5a06
Autor:
Yoshimi Nakagawa, Yunong Wang, Song-iee Han, Kanako Okuda, Asayo Oishi, Yuka Yagishita, Kae Kumagai, Hiroshi Ohno, Yoshinori Osaki, Yuhei Mizunoe, Masaya Araki, Yuki Murayama, Hitoshi Iwasaki, Morichika Konishi, Nobuyuki Itoh, Takashi Matsuzaka, Hirohito Sone, Nobuhiro Yamada, Hitoshi Shimano
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 949-971 (2021)
Background & Aims: cAMP responsive element-binding protein 3 like 3 (CREB3L3) is a membrane-bound transcription factor involved in the maintenance of lipid metabolism in the liver and small intestine. CREB3L3 controls hepatic triglyceride and glucose
Externí odkaz:
https://doaj.org/article/bce56fc30a3344359dbfa3a4b2fbc9ba
Autor:
Kaori Cho, Takashi Ushiki, Hajime Ishiguro, Suguru Tamura, Masaya Araki, Tatsuya Suwabe, Takayuki Katagiri, Mari Watanabe, Yoko Fujimoto, Riuko Ohashi, Yoichi Ajioka, Ippei Shimizu, Shujiro Okuda, Masayoshi Masuko, Yoshimi Nakagawa, Hideyo Hirai, Warren S. Alexander, Hitoshi Shimano, Hirohito Sone
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103117- (2021)
Summary: The suppressors of cytokine signaling (SOCS) proteins are negative regulators of cytokine signaling required to prevent excessive cellular responses. In particular, SOCS3 is involved in the regulation of metabolic syndromes, such as obesity
Externí odkaz:
https://doaj.org/article/34e2d4ec42e346c4b64b50eea980212d
Autor:
Yasunari Yamada, Hodaka Saito, Masaya Araki, Yuhei Tsuchimoto, Shin-ichi Muroi, Kyohei Suzuki, Kazufumi Toume, Jun-Dal Kim, Takashi Matsuzaka, Hirohito Sone, Hitoshi Shimano, Yoshimi Nakagawa
Publikováno v:
Nutrients, Vol 14, Iss 19, p 3920 (2022)
Fibroblast growth factor 21 (FGF21), which is mainly synthesized and secreted by the liver, plays a crucial role in systemic glucose and lipid metabolism, ameliorating metabolic diseases. In this study, we screened the WAKANYAKU library derived from
Externí odkaz:
https://doaj.org/article/5d60c96dc6654c8aa7ab1611216b7918
Autor:
Aoi Satoh, Song-iee Han, Masaya Araki, Yoshimi Nakagawa, Hiroshi Ohno, Yuhei Mizunoe, Kae Kumagai, Yuki Murayama, Yoshinori Osaki, Hitoshi Iwasaki, Motohiro Sekiya, Morichika Konishi, Nobuyuki Itoh, Takashi Matsuzaka, Hirohito Sone, Hitoshi Shimano
Publikováno v:
iScience, Vol 23, Iss 3, Pp - (2020)
Summary: Mice overexpressing the nuclear form of CREBH mainly in the liver (CREBH-Tg) showed suppression of high-fat high-sucrose (HFHS) diet-induced obesity accompanied by an increase in plasma fibroblast growth factor 21 (FGF21) levels. CREBH overe
Externí odkaz:
https://doaj.org/article/d7967aadf1e240c7bf75f7b3a6059d4c
Publikováno v:
Nutrients, Vol 13, Iss 9, p 3204 (2021)
Cyclic AMP-responsive element-binding protein H (CREBH, encoded by CREB3L3) is a membrane-bound transcriptional factor expressed in the liver and small intestine. The activity of CREBH is regulated not only at the transcriptional level but also at th
Externí odkaz:
https://doaj.org/article/9974c8f6ff794dc19341695134bbfbea
Autor:
Riho Yamada, Shizuka Odamaki, Masaya Araki, Tasuku Watanabe, Keigo Matsuo, Kaito Uchida, Taku Kato, Yori Ozaki-Masuzawa, Asako Takenaka
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0219603 (2019)
Leptin is an adipokine that regulates adipose tissue mass through membrane-anchored leptin receptor (Ob-R). Extracellular domain of Ob-R in plasma is called soluble leptin receptor (sOb-R), and is the main leptin-binding protein. Based on a previous
Externí odkaz:
https://doaj.org/article/cd4f6ba0731b49a485406a5f357cba6f
Autor:
Masaya Araki, Yoshimi Nakagawa, Asayo Oishi, Song-iee Han, Yunong Wang, Kae Kumagai, Hiroshi Ohno, Yuhei Mizunoe, Hitoshi Iwasaki, Motohiro Sekiya, Takashi Matsuzaka, Hitoshi Shimano
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 7, p 2148 (2018)
Peroxisome proliferator-activated receptor α (PPARα) is a therapeutic target for hyperlipidemia. Pemafibrate (K-877) is a new selective PPARα modulator activating PPARα transcriptional activity. To determine the effects of pemafibrate on diet-ind
Externí odkaz:
https://doaj.org/article/268763851975490185def28a7feb67cd