Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Masatoshi Wakamori"'
Autor:
Akari Miwa, Masatoshi Wakamori, Tetsuro Ariyoshi, Yasushi Okada, Mikako Shirouzu, Takashi Umehara, Koki Kamiya
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract To develop artificial cell models that mimic living cells, cell-sized lipid vesicles encapsulating cell-free protein synthesis (CFPS) systems are useful for protein expressions or artificial gene circuits for vesicle–vesicle communications
Externí odkaz:
https://doaj.org/article/e556d5036f8846bba93418939d59267e
Autor:
Masaki Kikuchi, Satoshi Morita, Masatoshi Wakamori, Shin Sato, Tomomi Uchikubo-Kamo, Takehiro Suzuki, Naoshi Dohmae, Mikako Shirouzu, Takashi Umehara
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Histone acetylation is important for the activation of gene transcription but little is known about its direct read/write mechanisms. Here, we report cryogenic electron microscopy structures in which a p300/CREB-binding protein (CBP) multido
Externí odkaz:
https://doaj.org/article/acaf383597024ad590d456fce9a48fc8
Autor:
Ayako Furukawa, Masatoshi Wakamori, Yasuhiro Arimura, Hideaki Ohtomo, Yasuo Tsunaka, Hitoshi Kurumizaka, Takashi Umehara, Yoshifumi Nishimura
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105408- (2022)
Externí odkaz:
https://doaj.org/article/4c08afbc89814082b417b06881f3110d
Autor:
Lusy Handoko, Bogumil Kaczkowski, Chung-Chau Hon, Marina Lizio, Masatoshi Wakamori, Takayoshi Matsuda, Takuhiro Ito, Prashanti Jeyamohan, Yuko Sato, Kensaku Sakamoto, Shigeyuki Yokoyama, Hiroshi Kimura, Aki Minoda, Takashi Umehara
Publikováno v:
Epigenetics, Vol 13, Iss 4, Pp 410-431 (2018)
The bromodomain and extra-terminal domain (BET) proteins are promising drug targets for cancer and immune diseases. However, BET inhibition effects have been studied more in the context of bromodomain-containing protein 4 (BRD4) than BRD2, and the BE
Externí odkaz:
https://doaj.org/article/a5a3e24b8e2b44a8ae4456359d3ec093
Autor:
Hideaki Ohtomo, Shinsuke Ito, Nicholas J. McKenzie, Michael Uckelmann, Masatoshi Wakamori, Haruhiko Ehara, Ayako Furukawa, Yasuo Tsunaka, Marika Shibata, Shun-ichi Sekine, Takashi Umehara, Chen Davidovich, Haruhiko Koseki, Yoshifumi Nishimura
Publikováno v:
Journal of molecular biology.
Polycomb repressive complex 1 (PRC1) and PRC2 are responsible for epigenetic gene regulation. PRC1 ubiquitinates histone H2A (H2Aub), which subsequently promotes PRC2 to introduce the H3 lysine 27 tri-methyl (H3K27me3) repressive chromatin mark. Alth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7692e309e49b94f65c8f114bde2e92a2
https://pubmed.ncbi.nlm.nih.gov/36610636
https://pubmed.ncbi.nlm.nih.gov/36610636
Autor:
Masaki Kikuchi, Satoshi Morita, Mie Goto, Masatoshi Wakamori, Kazushige Katsura, Kazuharu Hanada, Mikako Shirouzu, Takashi Umehara
Publikováno v:
The Journal of biological chemistry. 298(8)
Acetylated lysine residues (Kac) in histones are recognized by epigenetic reader proteins, such as Yaf9, ENL, AF9, Taf14, and Sas5 (YEATS) domain-containing proteins. Human YEATS domains bind to the acetylated N-terminal tail of histone H3; however,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80cf65c1c332ecaca6c0db548d7a77da
https://pubmed.ncbi.nlm.nih.gov/35732209
https://pubmed.ncbi.nlm.nih.gov/35732209
Autor:
Yoshifumi Nishimura, Masatoshi Wakamori, Ayako Furukawa, Takashi Umehara, Yasuo Tsunaka, Hideaki Ohtomo, Hitoshi Kurumizaka, Yasuhiro Arimura
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
The structural unit of eukaryotic chromatin is a nucleosome, comprising two histone H2A-H2B heterodimers and one histone (H3-H4) 2 tetramer, wrapped around by ∼146 bp of DNA. The N-terminal flexible histone tails stick out from the histone core and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9693f315664498e69a5e184f482e19ce
http://europepmc.org/articles/PMC7443954
http://europepmc.org/articles/PMC7443954
Autor:
Hidetoshi Kono, Shun Sakuraba, Yasuhiro Arimura, Hideaki Ohtomo, Hitoshi Kurumizaka, Yoshifumi Nishimura, Yasuo Tsunaka, Jun-ichi Kurita, Takashi Umehara, Zhenhai Li, Masatoshi Wakamori
Publikováno v:
Journal of molecular biology. 433(15)
The nucleosome comprises two histone dimers of H2A-H2B and one histone tetramer of (H3-H4)
wrapped around by ~145bp of DNA. Detailed core structures of nucleosomes have been established by X-ray and cryo-EM, however, histone tails have not been
wrapped around by ~145bp of DNA. Detailed core structures of nucleosomes have been established by X-ray and cryo-EM, however, histone tails have not been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0846bb3a7e3a5bb488fac97fe7c186c0
https://pubmed.ncbi.nlm.nih.gov/34153285
https://pubmed.ncbi.nlm.nih.gov/34153285
Autor:
Kiyoe Ura, Takashi Umehara, Takashi Funatsu, Masatoshi Wakamori, Kohki Okabe, Masahiro Takinoue
Publikováno v:
Nucleic Acids Research
Eukaryotic transcription is epigenetically regulated by chromatin structure and post-translational modifications (PTMs). For example, lysine acetylation in histone H4 is correlated with activation of RNA polymerase I-, II-, and III-driven transcripti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98b3f33b91743d745aea277248444996
https://pubmed.ncbi.nlm.nih.gov/33238306
https://pubmed.ncbi.nlm.nih.gov/33238306
Autor:
Shun-ichi Sekine, Haruhiko Ehara, Noriyuki Suka, Takashi Umehara, Shin Sato, Shigeyuki Yokoyama, Toshiaki Higo, Hideaki Maeda, Masatoshi Wakamori
Publikováno v:
Journal of Structural and Functional Genomics
We developed a method for efficient chromosome tagging in Pichia pastoris, using a useful tandem affinity purification (TAP) tag. The TAP tag, designated and used here as the THF tag, contains a thrombin protease cleavage site for removal of the TAP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41078bf87570f750d77ade81f1f014e3
http://europepmc.org/articles/PMC4237914
http://europepmc.org/articles/PMC4237914