Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Masatoshi Aida"'
Publikováno v:
Cell Cycle
Somatic hypermutation (SHM) requires not only the expression of activation-induced cytidine deaminase, but also transcription in the target regions. However, how transcription guides activation-induced cytidine deaminase in targeting SHM to the Ig ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc001bc578ee1b007146d83308941f0
https://doi.org/10.1073/pnas.1305859110
https://doi.org/10.1073/pnas.1305859110
Autor:
Tadashi Wada, Hiroshi Handa, Masatoshi Aida, Yuki Yamaguchi, Yexi Chen, Junichi Yamamoto, Sol Kim
Publikováno v:
Genes to Cells. 15:1003-1013
Recent estimates indicate that ∼60% of human genes include alternative polyadenylation sites. Hence, control of alternative polyadenylation can have a great impact on gene expression and cellular function. Cleavage factor (CF) Im is a 3′-end proc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d9247931ec72e13cb97d1df1db2cc65
https://doi.org/10.1111/j.1365-2443.2010.01436.x
https://doi.org/10.1111/j.1365-2443.2010.01436.x
Autor:
Mikiyo Nakata, Kazuo Kinoshita, Hitoshi Nagaoka, Reiko Shinkura, Maki Kobayashi, Andre Stanlie, Yoko Kitawaki, Nasim A. Begum, Masamichi Muramatsu, Tomomitsu Doi, Tasuku Honjo, Lucia Kato, Il-mi Okazaki, Masatoshi Aida
Publikováno v:
Proceedings of the National Academy of Sciences. 106:22375-22380
To initiate class switch recombination (CSR) activation-induced cytidine deaminase (AID) induces staggered nick cleavage in the S region, which lies 5 to each Ig constant region gene and is rich in palindromic sequences. Topoisomerase 1 (Top1) contro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5124e9b1961a3c9b28459b94377cc691
https://doi.org/10.1073/pnas.0911879106
https://doi.org/10.1073/pnas.0911879106
Publikováno v:
Mol. Cell. Biol.. 26(16):6094-6104
In eukaryotic cells, the regulation of preinitiation complex (PIC) assembly is essential to control gene expression (26), yet recent studies indicate that post-PIC assembly processes are also critical (27). At the human α1-AT locus, transcription in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f354548c294999c780d10c3c76151abf
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100524642
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100524642
Autor:
Eriko Okada, Hiroshi Handa, Motomi Yamazaki, Shin Namiki, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe, Ryuichi Okamoto, Yuki Yamaguchi, Takanori Yokota, Shigeru Oshima, Takanori Kanai, Masatoshi Aida
Publikováno v:
Molecular and Cellular Biology. 24:6298-6310
Intestinal epithelial cell-derived interleukin (IL)-7 functions as a pleiotropic and nonredundant cytokine in the human intestinal mucosa; however, the molecular basis of its production has remained totally unknown. We here showed that human intestin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ba0bed014c3357f9eff60e699761d52
https://doi.org/10.1128/mcb.24.14.6298-6310.2004
https://doi.org/10.1128/mcb.24.14.6298-6310.2004
Autor:
Tomoko Yamada, Wenyan Zhu, Jun Hasegawa, Hiroe Sato, Akiko Furuya, Takashi Narita, Masatoshi Aida, Naoto Inukai, Hajime Watanabe, Danny Reinberg, Tadashi Wada, Subhrangsu S. Mandal, Masaki Endoh, Hiroshi Handa, Yuki Yamaguchi, Dong-ki Kim
Publikováno v:
Mol. Cell. Biol.. 24(No. 8):3324-3336
Recent studies have suggested that Spt6 participates in the regulation of transcription by RNA polymerase II (RNAPII). However, its underlying mechanism remains largely unknown. One possibility, which is supported by genetic and biochemical studies o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d9c5a67e78e429d00401c0d30e268ec
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100723515
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100723515
Autor:
Tasuku Honjo, Masatoshi Aida
Publikováno v:
Cell cycle (Georgetown, Tex.). 12(18)
The antigen stimulation-induced genetic diversification of the immunoglobulin (Ig) genes establishes the antibody memory, which is critical to rapid and efficient immune response upon subsequent exposure to the antigen. Although extensive studies hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136e2f6648eb4e39636951a06ed38b06
https://pubmed.ncbi.nlm.nih.gov/23610419
https://pubmed.ncbi.nlm.nih.gov/23610419
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 188(8)
An ortholog of activation-induced cytidine deaminase (AID) was, evolutionarily, the first enzyme to generate acquired immune diversity by catalyzing gene conversion and probably somatic hypermutation (SHM). AID began to mediate class switch recombina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359f3d1c51f3bca8c35e65892b9c18ca
https://pubmed.ncbi.nlm.nih.gov/22492685
https://pubmed.ncbi.nlm.nih.gov/22492685
Ig class switch recombination (CSR) requires expression of activation-induced cytidine deaminase (AID) and transcription through target switch (S) regions. Here we show that knockdown of the histone chaperone facilitates chromatin transcription (FACT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14dd5110b57ac2989f33d18dc7521369
https://europepmc.org/articles/PMC3009800/
https://europepmc.org/articles/PMC3009800/
Autor:
Sol, Kim, Junichi, Yamamoto, Yexi, Chen, Masatoshi, Aida, Tadashi, Wada, Hiroshi, Handa, Yuki, Yamaguchi
Publikováno v:
Genes to cells : devoted to molecularcellular mechanisms. 15(9)
Recent estimates indicate that approximately 60% of human genes include alternative polyadenylation sites. Hence, control of alternative polyadenylation can have a great impact on gene expression and cellular function. Cleavage factor (CF) Im is a 3'
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6aa334c6cdd38152a3c0da3d2b5a5dbb
https://pubmed.ncbi.nlm.nih.gov/20695905
https://pubmed.ncbi.nlm.nih.gov/20695905