Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Masatomo, Iwao"'
Autor:
Mai Izumida, Osamu Kotani, Hideki Hayashi, Chris Smith, Tsutomu Fukuda, Koushirou Suga, Masatomo Iwao, Fumito Ishibashi, Hironori Sato, Yoshinao Kubo
Publikováno v:
Viruses, Vol 14, Iss 4, p 816 (2022)
Lamellarin α 20-sulfate is a cell-impenetrable marine alkaloid that can suppress infection that is mediated by the envelope glycoprotein of human immunodeficiency virus type 1. We explored the antiviral action and mechanisms of this alkaloid against
Externí odkaz:
https://doaj.org/article/6ca6edef37b7450e8dbc2bc0a5a15488
Autor:
Masaaki Matsuura, Honami Yonezawa, Naoyuki Nishiya, Tomoko Sakyo, Shingo Dan, Tsutomu Fukuda, Masatomo Iwao, Yusuke Oku, Fumito Ishibashi, Yoko Furukawa, Yuka Sasaki, Takao Yamori, Masaru Ushijima, Yoshimasa Uehara, Tetsuo Mashima, Hiroyuki Seimiya, Akihiro Tomida, Chie Ishikawa, Keishi Otsu, Masanori Abe
Publikováno v:
Cancer Science
The emergence of acquired resistance is a major concern associated with molecularly targeted kinase inhibitors. The C797S mutation in the epidermal growth factor receptor (EGFR) confers resistance to osimertinib, a third‐generation EGFR‐tyrosine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4c37c62d785bb3926e6f2c019635be7
http://europepmc.org/articles/PMC8088975
http://europepmc.org/articles/PMC8088975
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 85:181-191
Benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-ones (BBPIs) are potent anticancer compounds having unique BBPIs ring system designed on the basis of the marine natural product lamellarin D. In this study, we describe an alternative synthesis of a 2-demeth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3031e050b26eed5e390f81bccaa2c49b
https://doi.org/10.1093/bbb/zbaa028
https://doi.org/10.1093/bbb/zbaa028
Autor:
Laurent Meijer, Masatomo Iwao, Fumito Ishibashi, Somsak Rucirawat, Poonsakdi Ploypradith, Olivier Lozach, Yoan Ferandin, Nolwenn Trinkler, Dianne Baunbæk
Publikováno v:
Marine Drugs, Vol 6, Iss 4, Pp 514-527 (2008)
Lamellarins, a family of hexacyclic pyrrole alkaloids originally isolated from marine invertebrates, display promising anti-tumor activity. They induce apoptotic cell death through multi-target mechanisms, including inhibition of topoisomerase I, int
Externí odkaz:
https://doaj.org/article/1403caf8c124459890701ffbc9852948
Autor:
Fumiyasu Okazaki, Kenyu Yoshida, Yuko Natsui, Masatomo Iwao, Fumito Ishibashi, Masahiro Fujimoto, Hideto To, Tsutomu Fukuda, Yusuke Nanjo
Publikováno v:
Bioorganic & Medicinal Chemistry. 27(2):265-277
A new class of topoisomerase I inhibitors containing the unprecedented benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-one (abbreviated as BBPI) ring system have been developed based on structure-activity relationship studies of the cytotoxic marine alkalo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e096189e6a8192eb7ce2286eb05572a5
http://hdl.handle.net/10069/38935
http://hdl.handle.net/10069/38935
Autor:
Tsutomu Fukuda, Masanari Kimura, Gen Onodera, Fumito Ishibashi, Naoki Yoshioka, Masatomo Iwao, Yuri Matsuo, Fuyuki Matsuoka
Publikováno v:
HETEROCYCLES. 99(2):1032-1052
Novel topoisomerase I inhibitors possessing the 5,13-dihydro- 6H-benzo[6,7]indolo[3,2-c]quinolin-6-one (BIQ) scaffold were designed and synthesized. This scaffold was constructed using sequential and regioselective functionalization of the pyrrole co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce0c90f037f014503b6ae18d22ff2d4
https://nagasaki-u.repo.nii.ac.jp/records/352
https://nagasaki-u.repo.nii.ac.jp/records/352
Publikováno v:
The Alkaloids. Chemistry and biology. 83
Lamellarins are marine alkaloids containing fused 14-phenyl-6H-[1]benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinoline or non-fused 3,4-diarylpyrrole-2-carboxylate ring systems. To date, more than 50 lamellarins have been isolated from a variety of marin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eceafda254004ae5947aae6d1a0eafe2
https://pubmed.ncbi.nlm.nih.gov/32098648
https://pubmed.ncbi.nlm.nih.gov/32098648
Lamellarins are marine alkaloids containing fused 14-phenyl-6H-[1]benzopyrano[4′,3′:4,5]pyrrolo[2,1-a]isoquinoline or non-fused 3,4-diarylpyrrole-2-carboxylate ring systems. To date, more than 50 lamellarins have been isolated from a variety of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fe3be2383b32861f01720d5d5b57c3f
https://doi.org/10.1016/bs.alkal.2019.10.001
https://doi.org/10.1016/bs.alkal.2019.10.001
Publikováno v:
HETEROCYCLES. 97(2):916-930
A method for the synthesis of 4,5-disubstituted pyrano[3,4-b]pyrrol-7-(1H)-ones has been developed in this study. The key reactions involved are the Sonogashira?Hagihara cross-coupling of methyl N-benzenesulfonyl-3-bromo-1H-pyrrole-2-carboxylate with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72ff6168ac0e7b269c9e80342ce4e32c
http://hdl.handle.net/10069/38946
http://hdl.handle.net/10069/38946
Autor:
Haruka Kamiyama, Katsura Kakoki, Hiroaki Yoshii, Masatomo Iwao, Tsukasa Igawa, Hideki Sakai, Hideki Hayashi, Toshifumi Matsuyama, Naoki Yamamoto, Yoshinao Kubo
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26180 (2011)
Inhibitors of endosome acidification or cathepsin proteases attenuated infections mediated by envelope proteins of xenotropic murine leukemia virus-related virus (XMRV) and Ebola virus, as well as ecotropic, amphotropic, polytropic, and xenotropic mu
Externí odkaz:
https://doaj.org/article/945a6d26e8774d8aa4c307478774ed4d