Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Masatomi Shimizu"'
Publikováno v:
Genes and Environment, Vol 42, Iss 1, Pp 1-12 (2020)
Abstract Background The standard Ames test strains owe their high sensitivity to chemical and physical mutagens to the episomal Y-family DNA polymerase RI encoded by the mucAB operon. The S. typhimurium test strains carry also another related samAB o
Externí odkaz:
https://doaj.org/article/82f95798056e4efdb42fbcb179ee5dec
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 819:14-19
Polyunsaturated fatty acids (PUFA) represent one of the main building blocks of cellular membranes and their varying composition impacts lifespan as well as susceptibility to cancer and other degenerative diseases. Increased intake of ω-3 PUFA is ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::833f5aeca107f9a558c96796f479916f
https://doi.org/10.1016/j.mrgentox.2017.05.004
https://doi.org/10.1016/j.mrgentox.2017.05.004
Publikováno v:
Mutagenesis. 31:687-693
We have previously reported that flocculation of a yeast co-transformed with the human DNA methyltransferase 1 (DNMT1) and DNMT3B genes was inhibited by DNMT inhibitors. It is well known that epigenetic mutagens can disturb nucleosome positioning via
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::069c6fb3bf1fc8d380bb37c9f819180b
https://doi.org/10.1093/mutage/gew041
https://doi.org/10.1093/mutage/gew041
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 760:73-76
Sodium azide is a strong mutagen which has been successfully employed in mutation breeding of crop plants. In biological systems, it is metabolized to azidoalanine, but further bioactivation to a putative ultimate mutagen as well as the nature of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75ed554a702ec6e8b501e557ab81887c
https://doi.org/10.1016/j.mrgentox.2013.10.006
https://doi.org/10.1016/j.mrgentox.2013.10.006
Autor:
Francesca M. Pisani, Yasuo Asami, Isamu Hayata, Masatomi Shimizu, Takehiko Nohmi, Masahiro Murakami
Publikováno v:
Genes to Cells. 11:3-11
Deamination of cytosine to uracil is a hydrolytic reaction that is greatly accelerated at high temperatures. The resulting uracil pairs with adenine during DNA replication, thereby inducing G:C to A:T transitions in the progeny. Interestingly, B-fami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd4b9c0c980e0f775c1ab65cf15002af
https://doi.org/10.1111/j.1365-2443.2005.00918.x
https://doi.org/10.1111/j.1365-2443.2005.00918.x
Publikováno v:
Environmental Mutagen Research. 26:159-165
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83a676babfbcf8d6e4f66bb21fdf4cdb
https://doi.org/10.3123/jems.26.159
https://doi.org/10.3123/jems.26.159
Autor:
Takehiko Nohmi, Francesca M. Pisani, Masatomi Shimizu, Mariarita De Felice, Yusuke Kanke, Petr Grúz
Publikováno v:
Nucleic Acids Research. 31:4024-4030
Spontaneous damage to DNA as a result of deamination, oxidation and depurination is greatly accelerated at high temperatures. Hyperthermophilic microorganisms constantly exposed to temperatures exceeding 80 degrees C are endowed with powerful DNA rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e35b116a9b9f0551d3a8df690bdccd7
https://doi.org/10.1093/nar/gkg447
https://doi.org/10.1093/nar/gkg447
Autor:
Hiroyuki Kamiya, Hideyoshi Harashima, Takehiko Nohmi, Masatomi Shimizu, Petr Grúz, Chikahide Masutani, Yusuke Kanke, Su-Ryang Kim, Francesca M. Pisani, Fumio Hanaoka
Publikováno v:
EMBO reports. 4:269-273
Deranged oxidative metabolism is a property of many tumour cells. Oxidation of the deoxynucleotide triphosphate (dNTP) pool, as well as DNA, is a major cause of genome instability. Here, we report that two Y-family DNA polymerases of the archaeon Sul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3cf28303a266df4f8974a4a36b70d95
https://doi.org/10.1038/sj.embor.embor765
https://doi.org/10.1038/sj.embor.embor765
Autor:
Masatomi Shimizu, Petr Grúz
Publikováno v:
Rejuvenation Research. 13:285-287
The polyunsaturated fatty acids in biological membranes serve as both the target and source of oxidative damage and can be regarded as the most unstable class of biomolecules in the body. Lipid peroxides arising from both spontaneous and enzymatic ox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c94b67e80e9802d58d8b2d378d0e11c3
https://doi.org/10.1089/rej.2009.0945
https://doi.org/10.1089/rej.2009.0945
Autor:
Masatomi Shimizu, Kiyoka Higashi-Okai, Emiko Kasahara, Akemi Hosoda, Yasuji Okai, Atsuo Sekiyama, Yukio Usui, Masayasu Inoue
Publikováno v:
Journal of UOEH. 34(4)
To estimate the potent immunomodulating effects of different types of traditional Japanese millet, we analyzed the effect of bran extracts of foxtail millet (Awa in Japanese), barnyard millet (Hie) and proso millet (Mochi-kibi) on nitric oxide (NO) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54eaf41cbc8389f03947f7a3e1505df9
https://pubmed.ncbi.nlm.nih.gov/23270252
https://pubmed.ncbi.nlm.nih.gov/23270252