Výsledky vyhledávání - "Masato Tsuyuguchi"

Bivalent binding mode of an amino-pyrazole inhibitor indicates the potentials for CK2α1-selective inhibitors

Autor: Asaka Ikeda, Masato Tsuyuguchi, Daisuke Kitagawa, Masaaki Sawa, Shinya Nakamura, Isao Nakanishi, Takayoshi Kinoshita

Publikováno v: Biochemical and biophysical research communications. 630

Casein kinase 2 (CK2) is a vital protein kinase that consists of two catalytic subunits (CK2α1 and/or CK2α2) and two regulatory subunits (CK2β). CK2α1 is a drug target for nephritis and cancers, while CK2α2 is a serious off-target because its in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee1af4a6c402fba04cce7456e8588015
https://pubmed.ncbi.nlm.nih.gov/36130444

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A promiscuous kinase inhibitor delineates the conspicuous structural features of protein kinase CK2a1

Autor: Masato Tsuyuguchi, Tetsuko Nakaniwa, Masaaki Sawa, Isao Nakanishi, Takayoshi Kinoshita

Publikováno v: Acta Crystallogr F Struct Biol Commun

Protein kinase CK2a1 is a serine/threonine kinase that plays a crucial role in the growth, proliferation and survival of cells and is a well known target for tumour and glomerulonephritis therapies. Here, the crystal structure of the kinase domain of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc1389cf39a13b1592009a58577f99a
https://doi.org/10.1107/s2053230x19008951

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The structure of POMGNT2 provides new insights into the mechanism to determine the functional O‐mannosylation site on $α$‐dystroglycan

Autor: Ryuichi Kato, Tomohiro Tanaka, Hiroshi Manya, Tamao Endo, Rieko Imae, Mamoru Mizuno, Naoyuki Kuwabara, Masato Tsuyuguchi

Publikováno v: Genes to cells 26(7), 485-494 (2021). doi:10.1111/gtc.12853
Genes to Cells

Genes to cells 26(7), 485-494 (2021). doi:10.1111/gtc.12853
Defects in the O-mannosyl glycan of ��-dystroglycan (��-DG) are associated with ��-dystroglycanopathy, a group of congenital muscular dystrophies. While ��-DG has many O

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4832aa99c08d917a9512815470fca41
https://bib-pubdb1.desy.de/record/472498

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Crystal structures of human CK2α2 in new crystal forms arising from a subtle difference in salt concentration

Autor: Takayoshi Kinoshita, Masato Tsuyuguchi, Tetsuko Nakaniwa

Publikováno v: Acta Crystallogr F Struct Biol Commun

The catalytic subunits of protein kinase CK2 are classified into two subtypes: CK2α1 and CK2α2. CK2α1 is an attractive drug-discovery target for various diseases such as cancers and nephritis. CK2α2 is defined as an off-target of CK2α1 and is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f884c57f3d1e6fc06596661c648463d0
https://doi.org/10.1107/s2053230x18005204

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Structural insights for producing CK2α1-specific inhibitors

Autor: Takayoshi Kinoshita, Masato Tsuyuguchi, Tetsuko Nakaniwa, Isao Nakanishi, Akira Hirasawa

Publikováno v: Bioorganicmedicinal chemistry letters. 30(2)

Casein kinase 2 catalytic subunit (CK2α) is classified into two subtypes CK2α1 and CK2α2. CK2α1 is a drug discovery target, whereas CK2α2 is an off-target of CK2α1 inhibitors. High amino acid sequence homology between these subtypes hampers eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94d3300267b29acba1c57d044b48d960
https://pubmed.ncbi.nlm.nih.gov/31859160

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