Výsledky vyhledávání - "Masato Tawata"

Determination of Normal Ranges of Mitochondrial Respiratory Activities by mtDNA Transfer from 54 Human Subjects to mtDNA-less HeLa Cells for Identification of the Pathogenicities of Mutated mtDNAs

Autor: Yukihiko Momiyama, Kaori Ishikawa, Shoichi Arai, Kazuto Nakada, Masato Tawata, Jun-Ichi Hayashi, Rumiko Matsuoka, Chu-Shih Chen, Haruka Murakami, Shinya Kuno

Publikováno v: Journal of Biochemistry. 135:237-243

To determine the pathogenicities of mutated mtDNAs in patients with respiration defects, the possible involvement of nuclear DNA mutations has to be excluded, since respiratory function is controlled by both nuclear DNA and mtDNA. This was achieved b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3b46e4cd936f3414767daad33f17eff
https://doi.org/10.1093/jb/mvh028

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DNA demethylation modulates mouse leptin promoter activity during the differentiation of 3T3-L1 cells

Autor: Masato Tawata, Toshimasa Onaya, N Yokomori

Publikováno v: Diabetologia. 45:140-148

The mouse leptin gene, a major hormonal regulator of appetite and fat cell mass, expresses during the differentiation of 3T3-L1 preadipocytes to adipocytes. To determine if DNA methylation is involved in regulating the expression of the leptin gene,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b75c58c8c587c6a0e04c0cd27269f89b
https://doi.org/10.1007/s125-002-8255-4

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Cytoplasmic Transfer of Platelet mtDNA from Elderly Patients with Parkinson's Disease to mtDNA-less HeLa Cells Restores Complete Mitochondrial Respiratory Function

Autor: Jun-Ichi Hayashi, Rumiko Matsuoka, Hidehiro Mizusawa, Shinya Kuno, Sayaka Ito, Haruka Murakami, Yuko Aomi, Kazuto Nakada, Chu-Shih Chen, Kotoyo Isobe, Masato Tawata

Publikováno v: Biochemical and Biophysical Research Communications. 280:265-273

For determination of whether platelet mtDNA in patients with Parkinson's disease (PD) possesses some lesions to reduce respiratory enzyme activities, platelet mtDNA was transferred into mtDNA-less (rho0) HeLa cells from aged PD patients and age-match

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec2b08cefe5407a4e7d7cb7ec41ebac
https://doi.org/10.1006/bbrc.2000.4113

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A Patient with Type 2 Diabetes Mellitus Associated with Mutations in Calcium Sensing Receptor Gene and Mitochondrial DNA

Autor: Kotoyo Isobe, Jing Chen, Masato Tawata, Eizo Ohkubo, Toshimasa Onaya, Jun-Ichi Hayashi, Kaoru Aida

Publikováno v: Biochemical and Biophysical Research Communications. 278:808-813

A 44-year-old female with familial hypocalciuric hypercalcemia (FHH) due to a homozygous missense mutation (Pro40Ala) in calcium sensing receptor (CaSR) gene has type 2 diabetes mellitus. The identical heterozygous mutation of CaSR gene was observed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92a1f6dcc2d1a878280dc743123781d6
https://doi.org/10.1006/bbrc.2000.3867

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Disruption of Aldose Reductase Gene (Akr1b1) Causes Defect in Urinary Concentrating Ability and Divalent Cation Homeostasis

Autor: Jing Chen, Kaoru Aida, Yukinobu Ikegishi, Sadahiro Ito, Toshimasa Onaya, Masato Tawata, Shuichiro Maeda

Publikováno v: Biochemical and Biophysical Research Communications. 277:281-286

Aldose reductase (AKR1B1) is the first enzyme in the polyol pathway through which glucose is converted to sorbitol, and has been implicated in the etiology of diabetic complications. However, its physiological role is still not well understood. In th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963ed3e11573581d54122b176a106291
https://doi.org/10.1006/bbrc.2000.3648

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Screening for Genetic Mutations. A Review

Autor: Toshimasa Onaya, Masato Tawata, Kaoru Aida

Publikováno v: Combinatorial Chemistry & High Throughput Screening. 3:1-9

A point mutation of a nucleotide within a single gene can have a profound effect on a specific organ and or the entire human body. DNA sequences associated with human diseases may differ from the corresponding normal sequences by single nucleotide mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b026b1b12460796ff74373c3616599
https://doi.org/10.2174/1386207003327756

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A transcriptional repressor regulates mouse GLUT4 gene expression during the differentiation of 3T3-L1 cells

Autor: Masato Tawata, N Yokomori, Toshimasa Onaya

Publikováno v: Diabetes. 48:2471-2474

GLUT4, the major glucose transporter in adipose tissue, is expressed during the differentiation of 3T3-L1 cells from preadipocytes to adipocytes. We previously examined the mouse GLUT4 promoter activity up to -590 bp, and demonstrated that the 5'-fla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53169b5bd4a02af34f586de19535b7e3
https://doi.org/10.2337/diabetes.48.12.2471

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Z-4 allele upstream of the aldose reductase gene is associated with proliferative retinopathy in Japanese patients with NIDDM, and elevated luciferase gene transcription in vitro

Autor: Kaoru Aida, Yukinobu Ikegishi, Masato Tawata, Toshimasa Onaya

Publikováno v: Life Sciences. 65:2061-2070

We determined by PCR the number of (A-C)n repeats in the 2. 1 kb upstream of the aldose reductase (AR2) gene in healthy control subjects and in patients with NIDDM in Japanese. Sixty-one patients were recruited based on the severity of retinopathy an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77eb77abfc31f71400d7715818b74039
https://doi.org/10.1016/s0024-3205(99)00329-x

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Cilostazol, a cyclic AMP phosphodiesterase inhibitor, stimulates nitric oxide production and sodium potassium adenosine triphosphatase activity in SH-SY5Y human neuroblastoma cells

Autor: Masato Tawata, Toshimasa Onaya, Hidetoshi Inada, Hideo Shindo

Publikováno v: Life Sciences. 65:1413-1422

Deficiencies in cellular cyclic AMP (cAMP) and nitric oxide (NO) production are thought to be involved in the pathogenesis of diabetic neuropathy. We used a human neuroblastoma cell line, SH-SY5Y, to investigate the effect of cilostazol, a specific c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adfdc66fa48b324961b987bab571adb3
https://doi.org/10.1016/s0024-3205(99)00379-3

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Induction of Rat Aldose Reductase Gene Transcription Is Mediated through the cis-Element, Osmotic Response Element (ORE): Increased Synthesis and/or Activation by Phosphorylation of ORE-Binding Protein Is a Key Step

Autor: Kaoru Aida, Yukinobu Ikegishi, Toshimasa Onaya, Masato Tawata

Publikováno v: Endocrinology. 140:609-617

We isolated the rat aldose reductase gene and examined the 5′-flanking sequence for the presence of transcription regulatory element responsive to hyperosmolarity. Deletion of aldose reductase gene up to− 1047 bp abolished the transcriptional act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a86465f5bbbcc52941eab12b343b7d
https://doi.org/10.1210/endo.140.2.6515

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